Creating a Global fRAmework of Data collection Used for Adolescent HIV Transition Evaluation (GRADUATE)

创建用于青少年艾滋病毒过渡评估的全球数据收集框架（研究生）

• 批准号: 9321396
• 负责人: Mary-Ann Davies
• 金额: $ 11.98万
• 依托单位: FOUNDATION FOR AIDS RESEARCH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9321396
• 关键词: Address; Adolescence; Adolescent; Adolescent and Young Adult; Adult; Africa South of the Sahara; Age; Asia; Behavioral; Caring; Categories; Childhood; Clinic; Clinical; Computer software; Consensus; Country; Data; Data Collection; Databases; Development; Diagnostic radiologic examination; Ensure; Epidemic; Epidemiologic Monitoring; Evaluation; Failure; Family; HIV; Healthcare; Income; Individual; Infant; Infection; Information Systems; Internist; Intervention; Laboratories; Long-Term Survivors; Malawi; Measurement; Methods; Outcome; Patients; Perinatal Infection; Policy Maker; Preparation; Process; Provider; Questionnaires; Reporting; Research; Research Infrastructure; Research Personnel; Risk Behaviors; Risk Factors; South Africa; Southern Africa; Surveillance Program; System; Testing; Thailand; antiretroviral therapy; care systems; clinical care; cohort; data access; data management; epidemiology study; experience; innovation; low and middle-income countries; novel; outcome prediction; pediatrician; programs; routine care; sex; socioeconomics; success; surveillance data; tool; uptake; young adult; young man; young woman

PROJECT SUMMARY There are more than four million adolescents and young adults living with HIV in the world today. However, there are no mechanisms within current global surveillance data systems to distinguish how many of these young people were infected as infants or acquired HIV through risk behaviors in adolescence/young adulthood, and what proportion has subsequently transitioned from pediatric to adult HIV care. In order to address this serious gap, there is a critical need to harmonize HIV clinical and program data across the adolescent-to-adult HIV care transition period in a way that would be implementable in low- and middle-income country (LMIC) settings. The proposed research initiative, Creating a Global fRAmework of Data collection Used for Adolescent HIV Transition Evaluation (GRADUATE), seeks to establish a data collection and management platform that can guide clinical programs as to the demographic, socio-economic, clinical, and laboratory data they should be documenting in order to describe how adolescents are moving through the transition period within clinical care systems. GRADUATE would be created in the context of LMICs, where it could be used to conduct epidemiologic research and surveillance to understand how transition impacts program retention and antiretroviral therapy success or failure among young people. GRADUATE would promote a level of data granularity allowing disaggregation of data by age, sex, and infection exposure group that could dramatically change our understanding of how young women experience transitions in HIV care compared to young men, and of long-term survivors of perinatal infection compared to those infected at older ages. The new data management framework and research initiative would include 1) the identification of key variables and data definitions that capture the process of transition as well as the clinical and socio-economic predictors and outcomes across the transition period, 2) creation of data tables and online tools to facilitate data collection at the clinic level and for research purposes, and 3) pilot testing of the data-capture methods in Asia and sub-Saharan Africa at the patient level in individual clinics, within regional research cohort databases, and through a large provincial HIV program management and surveillance program. We hypothesize that a number of core indicators of the transition process can be derived from routine cohort data or can readily be captured through minimal additional data collection. We also hypothesize that transition success will vary across different settings and by sex, and that it will be possible to identify risk factors for poor transition outcomes that may be amenable to specific interventions. The proposed initiative will create the first broadly implementable and open access data platform to support measurement of adolescent HIV care transition outcomes.

项目摘要 当今世界上有超过四百万的青少年和年轻人生活在世界上。然而， 当前的全球监视数据系统中没有任何机制来区分其中有多少个 通过青春期/年轻人的风险行为，年轻人被感染为婴儿或获得的艾滋病毒， 以及随后从小儿过渡到成人艾滋病毒护理的比例。为了解决这个问题 严重的差距，迫切需要在整个成年 艾滋病毒护理过渡期以低收入和中等收入国家（LMIC）的方式实施 设置。拟议的研究计划，创建了用于用于的全球数据收集框架 青少年艾滋病毒过渡评估（研究生）试图建立数据收集和 可以指导人口统计学，社会经济的临床计划的管理平台 他们应该记录的临床和实验室数据，以描述青少年的 在临床护理系统内的过渡期。研究生将在 LMIC的背景，可以用来进行流行病学研究和监视以了解 过渡如何影响计划保留和抗逆转录病毒疗法的成功或年轻人失败。 毕业生将促进一定程度的数据粒度，允许按年龄，性别和性别分解数据 感染暴露组可能会极大地改变我们对年轻女性体验的理解 与年轻人相比 那些在年龄较大的年龄感染的人。新的数据管理框架和研究计划将包括1） 识别关键变量和数据定义，以捕获过渡过程以及 整个过渡期间的临床和社会经济预测因素和结果，2）创建数据表 和在线工具，以促进诊所层面和研究目的收集数据，以及3）试点测试 亚洲和撒哈拉以南非洲的数据捕获方法在各个诊所的患者层面， 区域研究队列数据库，并通过大型省级艾滋病毒计划管理和监视 程序。我们假设过渡过程的许多核心指标可以从 常规队列数据或可以通过最小的其他数据收集来轻易捕获。我们也假设 过渡成功将在不同的环境和性别因性别而异，并且有可能确定风险 可能适合特定干预措施的过渡结果不良的因素。拟议的倡议将 创建第一个可广泛的可实现和开放访问数据平台，以支持青少年的测量 艾滋病毒护理过渡结果。