International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.

评估艾滋病的国际流行病学数据库 (IeDEA) 南部非洲。

• 批准号: 10240757
• 负责人: Mary-Ann Davies
• 金额: $ 340万
• 依托单位: UNIVERSITAT BERN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10240757
• 关键词: 2019-nCoV; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent and Young Adult; Adult; Adverse event; Affect; Africa; Africa South of the Sahara; African; Anti-Retroviral Agents; Breast Feeding; COVID-19; COVID-19 pandemic; Caring; Cervical Cancer Screening; Child; Clinical; Collaborations; Data; Data Collection; Data Linkages; Databases; Devices; Diagnosis; Diagnostic; Disease; Drug resistance; Drug resistance in tuberculosis; Epidemic; Epidemiology; European; Evaluation; Funding; Goals; HIV; HIV Seronegativity; HIV/TB; Hand; Health; Health Services; Health care facility; Health system; Hepatitis B; Hepatitis B Virus; Incidence; Individual; Infant; Infection; International; Joints; Leadership; Life Cycle Stages; Life Expectancy; Liver; Lung diseases; Malignant Neoplasms; Mental Health; Mentorship; Metabolic; Methods; Modeling; Monitor; Outcome; Outcome Study; Output; Pharmaceutical Preparations; Policies; Pregnant Women; Prevalence Study; Prevention; Prevention program; Prevention strategy; Private Sector; Public Health; Pulmonary Tuberculosis; Quality of life; Regimen; Registries; Research; Research Personnel; Resistance; Risk; Risk Factors; SARS-CoV-2 transmission; Safety; Sentinel; Services; Sexually Transmitted Diseases; South Africa; South African; Southern Africa; Sputum; Statistical Models; Substance Use Disorder; Sustainable Development; Time; Translating; Treatment outcome; Tuberculosis; United Nations; United States; Universities; Viral; Woman; Work; World Health Organization; antiretroviral therapy; base; cancer care; cancer diagnosis; cancer health disparity; cancer prevention; cardiometabolic risk; cervical cancer prevention; co-infection; cohort; cost effective; data centers; data harmonization; digital; efavirenz; epidemiology study; gender equity; genome sequencing; health care settings; health data; implementation science; improved; improved outcome; in utero; innovation; low and middle-income countries; mathematical model; mortality; negative affect; new technology; novel; open data; point of care; pre-exposure prophylaxis; prevent; programs; resilience; screening; screening program; sequencing platform; social; substance use; targeted sequencing; therapy duration; tool; transmission process; treatment program; tuberculosis drugs; tuberculosis treatment; uptake

Southern Africa is the epicenter of the HIV and tuberculosis (TB) epidemic, and South Africa is at the center of the COVID-19 pandemic in Africa. There is an urgent need for robust epidemiology and implementation science to address the interacting burdens of HIV, TB, and other (emerging) coinfections and non-communicable diseases (NCDs). The International epidemiology Databases to Evaluate AIDS in Southern Africa (IeDEA-SA) has defined six specific aims for the fourth funding period (IeDEA-SA IV): (1) to study outcomes along the continuum of HIV care in adults; (2) to study outcomes in pregnant women, infants, children, and adolescents; (3) to study NCDs, hepatitis B and sexually transmitted infections (STIs); (4) to study the clinical and public health epidemiology of TB; (5) to study cancer prevention, burden, and care; and (6) to study mental health and substance use disorders. Further, we defined six cross-cutting themes: (i) the impact of the COVID-19 pandemic on health services; (ii) gender equity; (iii) capacity building; (iv) digital transformation; (v) open science; and (vi) the United Nations Sustainable Development Goals, which we will develop and prioritize within each aim. Innovations include the addition of the Western Cape Provincial Health Data Centre (WC PHDC), the South African HIV Cancer Match study, the establishment of pre-Exposure prophylaxis cohorts, and the evaluation of novel technologies (for example, a point-of-care genome-sequencing device, a hand-held colposcopic device for cervical cancer screening, or tools to study the transmission of TB in the health care setting) and novel statistical and mathematical modeling approaches. Multiregional Sentinel Research Networks (NCD-Sentinel Research Network [SRN], TB-SRN, Adolescent and Young Adult Network of IeDEA) on NCDs, TB, and adolescents and youth will harmonize data collection across the six IeDEA regions in low- and middle-income countries. The Fogarty-IeDEA Mentorship Program will strengthen capacity building among early-stage investigators. IeDEA-SA now follows nearly 1.3 million people living with HIV, including 285,000 individuals from the private sector (the Aid for AIDS program AfA), and 370,000 with ART duration > ten years. IeDEA IV will add data from 600,000 HIV-negative people through AfA and information from up to 4 million HIV-negative individuals from the WC PHDC in specific analyses. Within IeDEA, the Southern African region includes by far the largest number of adults and children. The COVID-19 pandemic now highlights the importance of epidemiologic research and implementation science across the health system. IeDEA-SA is well- placed to address the specific aims and cross-cutting themes outlined in this application, through its successful track-record of collaboration between the scientific and operational leadership at the Universities of Bern and Cape Town, partnership with several African universities (including the Kwazulu-Natal Research Innovation and Sequencing Platform), United States and European universities, and with the World Health Organization and the Joint United Nations Programme on HIV/AIDS.

南部非洲是艾滋病毒和结核病流行的中心，而南非是艾滋病毒和结核病的中心。 非洲的 COVID-19 大流行。迫切需要强大的流行病学和实施科学 解决艾滋病毒、结核病和其他（新出现的）混合感染和非传染性疾病的相互作用的负担 疾病（非传染性疾病）。评估南部非洲艾滋病的国际流行病学数据库 (IeDEA-SA) 为第四个资助期 (IeDEA-SA IV) 确定了六个具体目标： (1) 研究 成人艾滋病毒护理的连续性； (2) 研究孕妇、婴儿、儿童和青少年的结果； (3) 研究非传染性疾病、乙型肝炎和性传播感染（STI）； (4)研究临床和公共卫生 结核病流行病学； (5) 研究癌症的预防、负担和护理； (6) 研究心理健康和 物质使用障碍。此外，我们定义了六个跨领域主题：(i) COVID-19 的影响 大流行对卫生服务的影响； ㈡ 性别平等； (三) 能力建设； (四) 数字化转型； (v) 开放科学； (vi) 联合国可持续发展目标，我们将在每个目标中制定并优先考虑这些目标 目的。创新包括增加西开普省卫生数据中心 (WC PHDC)、 南非艾滋病毒癌症匹配研究、暴露前预防队列的建立以及 评估新技术（例如，床旁基因组测序设备、手持式设备） 用于宫颈癌筛查的阴道镜装置，或研究医疗保健中结核病传播的工具 设置）以及新颖的统计和数学建模方法。多区域哨点研究 网络（NCD-哨兵研究网络 [SRN]、TB-SRN、青少年和年轻人网络 关于非传染性疾病、结核病和青少年的 IeDEA）将协调 6 个 IeDEA 区域的数据收集 低收入和中等收入国家。 Fogarty-IeDEA 导师计划将加强能力建设 在早期研究人员中。 IeDEA-SA 目前正在追踪近 130 万艾滋病毒感染者，其中包括 来自私营部门的 285,000 名个人（艾滋病援助计划 AfA），以及 370,000 名接受 ART 治疗的人 > 十年。 IeDEA IV 将通过 AfA 添加 600,000 名 HIV 阴性人群的数据以及来自多达 4 个国家的信息 WC PHDC 的百万 HIV 阴性个体进行了具体分析。在 IeDEA 内，南部非洲 该地区包括迄今为止人数最多的成人和儿童。 COVID-19 大流行现在凸显了 整个卫生系统流行病学研究和实施科学的重要性。 IeDEA-SA 很好- 通过其成功的解决方案来解决本申请中概述的具体目标和跨领域主题 伯尔尼大学的科学和业务领导层之间的合作记录 开普敦，与几所非洲大学（包括夸祖鲁-纳塔尔研究创新中心）合作 和测序平台）、美国和欧洲大学以及世界卫生组织 和联合国艾滋病毒/艾滋病联合规划署。