Borrelia miyamotoi: mechanisms of tick colonization and transmission

宫本伯氏疏螺旋体：蜱的定植和传播机制

• 批准号: 9297214
• 负责人: Brian Stevenson
• 金额: $ 17.7万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9297214
• 关键词: Acute; Address; Adult; Anaplasma phagocytophilum; Area; Argasidae; Arthralgia; Babesia; Bacteria; Biology; Bite; Black-legged Tick; Borrelia; Borrelia burgdorferi; Borrelia miyamotoi; Climate; Diagnosis; Ehrlichia; Emerging Communicable Diseases; Exhibits; Exposure to; Fever; Geographic Locations; Health; Horizontal Disease Transmission; Hospitalization; Hour; Human; Immunocompromised Host; Incidence; Infection; Institute of Medicine (U.S.); Invaded; Ixodes; Ixodidae; Laboratories; Larva; Location; Lyme Disease; Maintenance; Meningoencephalitis; Midwestern United States; Myalgia; New England; Nymph; Ohio; Order Spirochaetales; Ornithodoros; Population; Prevalence; Proteins; Public Health; Publishing; Relapsing Fever; Reporting; Research Personnel; Risk; Rivers; Sampling; Seminal; Series; Seroprevalences; Site; Spirochaetales Infections; Symptoms; Tick-Borne Diseases; Tick-Borne Encephalitis Virus; Tick-Borne Encephalitis Viruses; Tick-Borne Infections; Ticks; Vertical Disease Transmission; Widespread Disease; differential expression; disorder prevention; experimental analysis; exposed human population; feeding; field study; laboratory experiment; land use; pathogen; transmission process; vector

ABSTRACT Human infection by the spirochete Borrelia miyamotoi is a newly-recognized public health threat in the US and other parts of the world. Borrelia miyamotoi infection may require hospitalization, with symptoms that include high fever, joint and muscle pain, and meningoencephalitis. B. miyamotoi is spread by the bites of infected Ixodes spp. ticks, but almost nothing is known about how or where the bacterium colonizes its vector, or the dynamics of transmission. This proposal brings together an expert team of Borrelia and tick researchers, who will conduct a series of synergistic studies that will greatly expand understanding of B. miyamotoi transmission and infection mechanisms.

抽象的 Spirochete Borrelia Miyamotoi感染的人类感染是美国新认识的公共卫生威胁 世界其他地区。宫廷伯氏感染可能需要住院，其中包括 高烧，关节和肌肉疼痛以及脑膜脑炎。 B. Miyamotoi被感染的叮咬传播 ixodes spp。 tick，但几乎一无所知，细菌如何或位置在其载体上定居或 传输动力。该提案汇集了一个专家团队，由Borrelia和Tick研究人员组成 将进行一系列协同研究，这些研究将大大扩展对宫类芽孢杆菌传播的理解 和感染机制。