Pathogenesis of Borrelia mayonii infection

马氏疏螺旋体感染的发病机制

• 批准号: 9263401
• 负责人: Brian Stevenson
• 金额: $ 24.83万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-24 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9263401
• 关键词: Address; Affinity; Amino Acids; Antigens; Bacteremia; Bacterial Adhesins; Blood Vessels; Borrelia; Borrelia burgdorferi; Chromosomes, Human, 4-5; Clinical; Complement; Development; Diagnosis; Diffuse; Disease; Employee Strikes; Event; Exanthema; Exhibits; Genes; Genetic; Geography; Goals; Hospitalization; Human; Inbred Mouse; Infection; Lyme Disease; Membrane Proteins; Midwestern United States; Modeling; Molecular; Mus; Myalgia; Neurologic Signs; Orthologous Gene; OspC protein; Pathogenesis; Pathogenicity; Pathologic; Pathology; Patients; Property; Proteins; Proteomics; Public Health; Reporting; Surface Antigens; Symptoms; Tick-Borne Diseases; Ticks; Tissues; Virulence Factors; insight; macula; mouse model; novel; outer surface lipoprotein; pathogen; tool

ABSTRACT Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known. Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit substantial genetic differences. We hypothesize that those differences are responsible for the distinct features of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B. mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B. mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and lay important groundwork for diagnosis and treatment.

抽象的 Borrelia Mayonii是一种新认可的tick传播疾病的原因。首先在上部报道 中西部在2016年2月，这一新兴公共卫生威胁的地理范围尚不清楚。 尽管B. mayonii与经典的莱姆病毒剂有关，但两种物种都显示 实质性遗传差异。我们假设这些差异是造成不同特征的原因 B. mayonii感染。两种疾病之间的显着差异是静止的 仅在感染芽孢杆菌的患者中观察到。 B. mayonii感染的其他症状包括黄斑 整个身体，肌痛和神经系统症状的皮疹，一些患者需要住院。三 我们的研究正在解决有关B. mayonii及其相关疾病的关键问题：（1）什么 是螺旋藻血症，组织病理学和其他传染性的范围。 Mayonii感染？ （2）什么原因导致B. mayonii期间发生的高级螺旋藻血症 感染，但没有在B. burgdorferi感染期间？ （3）B期间产生了哪些抗原蛋白。 Mayonii感染，但在B. burgdorferi感染期间却没有，可用于诊断这种新兴 疾病？我们研究的结果将提供有关B. mayonii和B.b。shoonii和 为诊断和治疗奠定重要的基础。