Pathogenesis of Borrelia mayonii infection

马氏疏螺旋体感染的发病机制

基本信息

批准号：
9263401
负责人：
Brian Stevenson
金额：
$ 24.83万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-24 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9263401
关键词：
Address Affinity Amino Acids Antigens Bacteremia Bacterial Adhesins Blood Vessels Borrelia Borrelia burgdorferi Chromosomes, Human, 4-5 Clinical Complement Development Diagnosis Diffuse Disease Employee Strikes Event Exanthema Exhibits Genes Genetic Geography Goals Hospitalization Human Inbred Mouse Infection Lyme Disease Membrane Proteins Midwestern United States Modeling Molecular Mus Myalgia Neurologic Signs Orthologous Gene OspC protein Pathogenesis Pathogenicity Pathologic Pathology Patients Property Proteins Proteomics Public Health Reporting Surface Antigens Symptoms Tick-Borne Diseases Ticks Tissues Virulence Factors insight macula mouse model novel outer surface lipoprotein pathogen tool

Address Affinity Amino Acids Antigens Bacteremia Bacterial Adhesins Blood Vessels Borrelia Borrelia burgdorferi Chromosomes, Human, 4-5 Clinical Complement Development Diagnosis Diffuse Disease Employee Strikes Event Exanthema Exhibits Genes Genetic Geography Goals Hospitalization Human Inbred Mouse Infection Lyme Disease Membrane Proteins Midwestern United States Modeling Molecular Mus Myalgia Neurologic Signs Orthologous Gene OspC protein Pathogenesis Pathogenicity Pathologic Pathology Patients Property Proteins Proteomics Public Health Reporting Surface Antigens Symptoms Tick-Borne Diseases Ticks Tissues Virulence Factors insight macula mouse model novel outer surface lipoprotein pathogen tool

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项目摘要

ABSTRACT Borrelia mayonii is the causative agent of a newly-recognized tick-borne disease. First reported in the upper Midwest during February, 2016, the geographic range of this emerging public health threat is not yet known. Although B. mayonii is related to the classic Lyme disease agent, Borrelia burgdorferi, the two species exhibit substantial genetic differences. We hypothesize that those differences are responsible for the distinct features of B. mayonii infection. A striking difference between the two diseases is the high spirochetemia that has been observed only in patients infected with B. mayonii. Other symptoms of B. mayonii infection include macular rashes across the body, myalgia, and neurological signs, with some patients requiring hospitalization. Three critical questions about B. mayonii and its associated disease are being addressed by our studies: (1) What are the extents of spirochetemia, tissue pathology, and other infectious qualities in untreated mammalian B. mayonii infection? (2) What is responsible for the high-level spirochetemia that occurs during B. mayonii infection, but not during B. burgdorferi infection? and (3) What antigenic proteins are produced during B. mayonii infection, but not during B. burgdorferi infection, that can be used for diagnosis of this emerging disease? Results from our studies will provide valuable insight on the pathogenic properties of B. mayonii and lay important groundwork for diagnosis and treatment.

抽象的 Borrelia Mayonii是一种新认可的tick传播疾病的原因。首先在上部报道中西部在2016年2月，这一新兴公共卫生威胁的地理范围尚不清楚。尽管B. mayonii与经典的莱姆病毒剂有关，但两种物种都显示实质性遗传差异。我们假设这些差异是造成不同特征的原因 B. mayonii感染。两种疾病之间的显着差异是静止的仅在感染芽孢杆菌的患者中观察到。 B. mayonii感染的其他症状包括黄斑整个身体，肌痛和神经系统症状的皮疹，一些患者需要住院。三我们的研究正在解决有关B. mayonii及其相关疾病的关键问题：（1）什么是螺旋藻血症，组织病理学和其他传染性的范围。 Mayonii感染？（2）什么原因导致B. mayonii期间发生的高级螺旋藻血症感染，但没有在B. burgdorferi感染期间？（3）B期间产生了哪些抗原蛋白。 Mayonii感染，但在B. burgdorferi感染期间却没有，可用于诊断这种新兴疾病？我们研究的结果将提供有关B. mayonii和B.b。shoonii和为诊断和治疗奠定重要的基础。