Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 9312767
• 负责人: Scott D Cramer
• 金额: $ 37.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-07 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9312767
• 关键词: Cancer Biology; Training Programs

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis, and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis, and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz including world renown research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast, prostate and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. The Co-PIs of this training program have leadership roles within the institution that integrate the University of Colorado Cancer Center and the Graduate School into this training program. Dr. Cramer is co-director of the Hormone-Related Malignancies group within the Cancer Center and works with other Cancer Center leadership to establish goals and directions of the cancer center. Dr. Reyland is director of the Cancer Biology pre-doctoral training program, providing a strong link to the Graduate School. Additional integration comes from other training faculty who are all members of the Cancer Center (many with leadership roles), and several also have leadership roles in the Graduate School. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre-doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhDs. The total of 31 training faculty were selected based on their scientific expertise and track record of mentorship. Based on the NCIs postdoctoral/predoctoral training ratio of 3:1, this application proposes to appoint 3 new postdocs and 1 new predoctoral student in year 1, and 6 post-docs and 2 pre-doctoral students per award year for years 2-5. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.

抽象的 尽管过去几年我们对细胞和分子的基本理解取得了重大突破 导致癌症的变化、致癌过程中的许多关键步骤以及促进癌症发生的早期癌症的变化 侵袭和转移仍不明确。对未来年轻的癌症研究人员进行严格的培训 生物学对于我们寻求更深入地了解致癌作用以及发展 更好的早期癌症检测方法、改进的诊断和有效的新癌症治疗方法。这 癌症生物学培训计划 (TPCB) 是一个涵盖所有癌症亚型的多学科计划， 利用 CU Anschutz 的独特优势和培训机会，包括世界知名的研究 功能基因组学、实验疗法、类固醇受体信号传导、干细胞和器官特异性 癌症（特别是肺癌、乳腺癌、前列腺癌和血液癌）。我们的目标是提供跨学科培训 癌症研究的前沿，让我们的学员做好在生物医学研究环境中竞争的最佳准备 越来越注重基础研究的转化应用。我们的培训计划包括实验室 培训、教学活动、参加科学会议、专业发展和职业 指导、沟通技巧的发展以及临床观点的接触。该项目的共同PI 培训计划在整合科罗拉多大学癌症学院的机构内发挥领导作用 中心和研究生院纳入本次培训计划。克莱默博士是激素相关研究中心的联合主任 癌症中心内的恶性肿瘤小组并与其他癌症中心领导层合作制定目标 以及癌症中心的指示。 Reyland 博士是癌症生物学博士前培训项目的主任， 提供与研究生院的紧密联系。额外的整合来自其他培训教师，他们 癌症中心的所有成员（许多人担任领导职务），以及一些人还在癌症中心担任领导职务 研究所。来自癌症中心、研究生院和各个部门的资源 致力于支持培训计划。癌症中心的基础设施尤为重要 它为培训教师提供了可用的核心资源，因此受训者也可以使用这些资源。这 拟议的计划将包括通过癌症生物学研究生培训计划进行博士前培训， 它设在研究生院，并为博士提供博士后培训。培训师资总数31人 他们的选择是基于他们的科学专业知识和指导记录。基于 NCI 博士后/博士前培养比例为3:1，本申请拟聘任博士后3名，新聘博士1名 第 1 年为博士前学生，第 2-5 年每个奖励年有 6 名博士后和 2 名博士前学生。我们 将根据他们的研究和学术记录从外部和内部人才库中选择受训者 致力于癌症研究。我们致力于提供各个级别的全面培训，以便 为我们的学员在学术界内外的生物医学科学领域取得成功做好最好的准备。