Training Program in Cancer Biology

癌症生物学培训计划

• 批准号: 10670055
• 负责人: Scott D Cramer
• 金额: $ 39.44万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-07 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10670055
• 关键词: Cancer Biology; Training Programs

ABSTRACT Despite major breakthroughs over the past few years in our basic understanding of the cellular and molecular changes that lead to cancer, many key steps in carcinogenesis and changes in early cancers that promote invasion and metastasis, still remain poorly defined. Rigorous training of future young investigators in cancer biology will be essential in our quest for a deeper understanding of carcinogenesis and for the development of better methods of early cancer detection, improved diagnosis, and effective new cancer treatments. The Training Program in Cancer Biology (TPCB) is a multidisciplinary program across all cancer subtypes that capitalizes on the unique strengths and training opportunities at CU Anschutz, including world renowned research in functional genomics, experimental therapeutics, steroid receptor signaling, stem cells and organ specific cancers (in particular lung, breast and blood). Our goal is to provide interdisciplinary training at the cutting edge of cancer research to best prepare our trainees to compete in a biomedical research environment increasingly focused on translational applications of basic research. Our training plan consists of laboratory training, didactic activities, attendance at scientific conferences, professional development and career mentoring, development of communication skills, and exposure to the clinical perspective. Based on feedback from trainees and faculty, for this renewal we have added new training components, including mandatory mentor training and training in rigor and reproducibility. The renewal also includes expanded opportunities for training in quantitative biology and bioinformatics, and expanded clinical/translational and career development opportunities. The co-PIs of this training program have been leaders in Cancer Biology training at the University of Colorado Cancer Center and the Graduate School during the past 10 years. Resources from the Cancer Center, the Graduate School, and individual departments are committed to support the training program. The infrastructure of the Cancer Center is particularly important as it provides core resources available to training faculty that are therefore available to the trainees. The proposed program will include pre- doctoral training through the graduate training program in Cancer Biology, which is housed in the Graduate School, and post-doctoral training for PhD and PhD/MD scientists. A total of 38 training faculty were selected based on their scientific expertise and track record of mentorship. The first cycle of this T32 grant was highly successful, with all slots competitively filled. For the second cycle of this grant, we propose to support 4 postdoc and 4 predoctoral trainees each year. We will select trainees from external and internal pools based on their research and academic records and commitment to cancer research. We are committed to providing comprehensive training at all levels so as to best prepare our trainees for successful careers in biomedical science inside or outside academia.

抽象的 尽管过去几年我们对细胞和分子的基本理解取得了重大突破 导致癌症的变化、致癌过程中的许多关键步骤以及促进癌症发生的早期癌症的变化 侵袭和转移仍不明确。对未来年轻的癌症研究人员进行严格的培训 生物学对于我们深入了解致癌作用和发展癌症至关重要 更好的早期癌症检测方法、改进的诊断和有效的新癌症治疗方法。这 癌症生物学培训计划 (TPCB) 是一个涵盖所有癌症亚型的多学科计划， 利用 CU Anschutz 的独特优势和培训机会，包括世界知名的 功能基因组学、实验疗法、类固醇受体信号传导、干细胞和器官研究 特定癌症（特别是肺癌、乳腺癌和血癌）。我们的目标是提供跨学科培训 癌症研究的前沿，让我们的学员做好在生物医学研究环境中竞争的最佳准备 越来越注重基础研究的转化应用。我们的培训计划包括实验室 培训、教学活动、参加科学会议、专业发展和职业 指导、沟通技巧的发展以及临床观点的接触。根据反馈 来自学员和教职人员的培训，对于这次更新，我们添加了新的培训内容，包括强制性的 指导培训以及严格性和可重复性的培训。更新还包括扩大机会 定量生物学和生物信息学培训，以及扩大的临床/转化和职业发展 机会。该培训计划的共同 PI 一直是癌症生物学培训的领导者 科罗拉多大学癌症中心和研究生院过去 10 年。资源来自 癌症中心、研究生院和各个部门致力于支持培训 程序。癌症中心的基础设施尤为重要，因为它提供了核心资源 可供培训教师使用，因此也可供受训者使用。拟议的计划将包括预 通过癌症生物学研究生培训计划进行博士培训，该计划位于研究生院 博士和博士/医学博士科学家的学校和博士后培训。共选拔培训师资38名 基于他们的科学专业知识和指导记录。 T32 资助的第一个周期获得了高度评价 成功，所有空位都已竞争性地填补。对于本次赠款的第二个周期，我们建议支持 4 每年招收博士后和博士前4名。我们将从外部和内部人才库中选拔实习生 他们的研究和学术记录以及对癌症研究的承诺。我们致力于提供 各个级别的全面培训，以便为我们的学员在生物医学领域的成功职业生涯做好最好的准备 学术界内部或外部的科学。

项目成果

Src-mediated regulation of the PI3K pathway in advanced papillary and anaplastic thyroid cancer.

• DOI: 10.1038/s41389-017-0015-5
• 发表时间: 2018-02-28
• 期刊: Oncogenesis
• 影响因子: 6.2
• 作者: Beadnell TC;Nassar KW;Rose MM;Clark EG;Danysh BP;Hofmann MC;Pozdeyev N;Schweppe RE
• 通讯作者: Schweppe RE

Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.

• DOI: 10.1172/jci161659
• 发表时间: 2022-07-15
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Evans, Edward J., Jr.;DeGregori, James
• 通讯作者: DeGregori, James

Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes.

• DOI: 10.3390/cancers13133272
• 发表时间: 2021-06-30
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Jillson LK;Yette GA;Laajala TD;Tilley WD;Costello JC;Cramer SD
• 通讯作者: Cramer SD

CD38 antibody re-treatment in daratumumab-refractory multiple myeloma after time on other therapies.

• DOI: 10.1182/bloodadvances.2023010162
• 发表时间: 2023-11-14
• 期刊: BLOOD ADVANCES
• 影响因子: 7.5
• 作者: de Acha, Olivia Perez;Reiman, Lauren;Jayabalan, David S.;Walker, Zachary J.;Bosma, Grace;Keller, Alana L.;Parzych, Sarah E.;Abbott, Diana;Idler, Beau M.;Ribadeneyra, Drew;Niesvizky, Ruben;Forsberg, Peter A.;Mark, Tomer M.;Sherbenou, Daniel W.
• 通讯作者: Sherbenou, Daniel W.

Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer.

• DOI: 10.1007/s12672-017-0314-5
• 发表时间: 2018-04
• 期刊: Hormones & cancer
• 影响因子: 3
• 作者: Christenson JL;Trepel JB;Ali HY;Lee S;Eisner JR;Baskin-Bey ES;Elias AD;Richer JK
• 通讯作者: Richer JK