Hyperandrogenemia, Diet and Female Reproductive Health

高雄激素血症、饮食和女性生殖健康

• 批准号: 9039467
• 负责人: RICHARD L STOUFFER
• 金额: $ 193.94万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9039467
• 关键词: Address; Adipose tissue; Androgens; Awareness; California; Clinical; Collaborations; Diet; Etiology; Fatty acid glycerol esters; Female; Fertility; Fertility Disorders; Fructose; Functional disorder; Health Sciences; Human; Hypothalamic structure; Infertility; Lead; Los Angeles; Macaca mulatta; Metabolic; Modeling; Neurosecretory Systems; Obesity; Oregon; Ovarian; Ovary; Pituitary Gland; Population; Prevalence; Primates; Reproduction; Reproductive Health; Research; Research Project Grants; Resources; Role; Structure; Syndrome; Testosterone; Universities; Woman; design; improved; insight; nonhuman primate; outreach; programs; public health relevance; reproductive; reproductive tract; response; treatment effect; treatment group

DESCRIPTION (provided by applicant): The Oregon National Primate Research Center (ONPRC) at the Oregon Health & Science University (OHSU) proposes a Specialized Cooperative Center in Reproduction and Infertility Research (U54) that addresses the effects of hyperandrogenemia and obesity on female reproductive health. An interdisciplinary, translational program is designed to discern between the effects of excess androgen exposure and metabolic changes due to a typical Western-style diet (WSD, high fat and fructose content) on: (1) the hypothalamus-pituitary-ovary-reproductive tract axis, as well as adipose tissue; (2) the impact on fertility; and (3) if the treatment effects are reversible. Three research projects ue the nonhuman primate model, and one project focuses on the specific population of lean women with polycystic ovarian syndrome (PCOS). Project I, "Metabolic and Neuroendocrine Responses to Hyperandrogenemia and Diet", is directed by J. Cameron, via a consortium with the University of Pittsburgh and K. Grove at ONPRC. Project II, "Ovarian and Uterine Structure-Function: Influence of Androgen and Diet", is a collaboration between R. Stouffer and O. Slayden, ONPRC. Project III, "Effects of Androgen and Diet on Adipose Function," involves C. Roberts and colleagues at ONPRC. Project IV, "Androgen Excess as a Mechanism for Adipogenic Dysfunction in PCOS Women," incorporates a consortium with clinical experts (D. Dumesic, G. Chazenbalk) at the University of California, Los Angeles. Projects l-lll will be supported by a nonhuman primate (NHP) Core (O. Slayden, Supervisor) operating as a closed resource. This Core will maintain four treatment groups of young, female rhesus monkeys (controls, testosterone or T-treated, WSD-treated, and T + WSD) for four years, culminating in a fertility trial. In Year 05, reversibility of T and WSD actions will be examined. In addition, the Administrative Core (R. Stouffer, P.I.), and Outreach Core (D. Gordon and M. Zelinski) will promote interactions within and among SCCPIR Centers and increase public awareness and understanding of reproductive health research. Important, new information will accrue on the actions of androgen and diet-related factors, individually and in combination, relevant to the etiology and treatment of fertility disorders, such as PCOS.

描述（由申请人提供）：俄勒冈州健康与科学大学（OHSU）的俄勒冈州国家灵长类动物研究中心（ONPRC）提出了一个专业的生殖与不育研究中心（U54），该中心涉及高雄激素血症和肥胖对女性生殖健康的影响。跨学科的转化计划旨在辨别因典型的西方风格饮食（WSD，高脂和果糖含量）引起的过量雄激素暴露和代谢变化的影响：（1）下丘脑 - 垂体 - 垂体 - 植物 - 植物 - 复制性 - 复制性氨基酸链轴，以及脂肪蛋白的组织； （2）对生育的影响； （3）如果治疗效果是可逆的。三项研究项目UE是非人类灵长类动物模型，一个项目的重点是多囊卵巢综合征（PCOS）的瘦女性的特定人群。 项目I，“代谢和神经内分泌对高雄激素血症和饮食的反应”，由J. Cameron指导，通过与匹兹堡大学和ONPRC的K. Grove的财团有关。第二个项目，“卵巢和子宫结构功能：雄激素和饮食的影响”，是R. Stouffer与 O. Slayden，Onprc。项目III，“雄激素和饮食对脂肪功能的影响”，涉及ONPRC的Roberts及其同事。 IV项目，“雄激素过量作为PCOS妇女的成肌功能障碍的机制”，与洛杉矶分校的临床专家（D. Dumesic，G。Chazenbalk）合并了一个财团。项目L-LLL将得到非人类灵长类动物（NHP）核心（O. Slayden，主管）作为封闭资源的支持。该核心将在四年内维持四个年轻，雌性恒河猴（对照，睾丸激素或T + WSD）的治疗组（对照，睾丸激素或T + WSD），最终在一项生育试验中达到顶峰。在第05年，将检查T和WSD动作的可逆性。此外，行政核心（R. Stouffer，P.I。）和外展核心（D. Gordon和M. Zelinski）将促进Sccpir中心内外的互动，并提高公众对生殖健康研究的认识和理解。重要的是，新信息将与雄激素和饮食相关因素的作用相关，并与pCOS等生育障碍的病因和治疗有关。