CONTRACEPTION BY BLOCKADE OF PERIOVULATORY EVENTS IN PRIMATES (U54 CENTER)

通过阻断灵长类动物排卵期事件来避孕（U54 中​​心）

• 批准号: 8357760
• 负责人: RICHARD L STOUFFER
• 金额: $ 17.79万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357760
• 关键词: Address; Adult; Animals; Cells; Cervical; Contraceptive Agents; Contraceptive methods; Development; Drug Industry; Estrogens; Event; Female; Fertility; Fertilization; Funding; Grant; Individual; Macaca; Menstrual cycle; Modality; Monkeys; National Center for Research Resources; Nuclear; Oocytes; Ovary; Ovulation; Pharmaceutical Preparations; Primates; Principal Investigator; Progress Reports; Proteins; Publications; Research; Research Infrastructure; Research Project Grants; Resources; Rupture; Selective Estrogen Receptor Modulators; Source; Testing; Translational Research; United States National Institutes of Health; Woman; base; contraceptive efficacy; cost; egg; gamete transport; nonhuman primate; novel; oocyte maturation; prevent; reproductive; research and development

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development Research Center that targets the discovery and development of novel contraceptive drugs that prevent one or more periovulatory events in adult, female primates during the menstrual cycle. Three research projects and one animal core utilize Old World (macaque) monkeys to generate new information and proof-of-concept regarding modalities that prevent oocyte fertilization, and hence fertility, in women. Project I, "Control of Oocyte Maturation", will address the hypothesis that novel follicle cell-, and oocyte-derived proteins control nuclear and cytoplasmic maturation of the oocyte, and can be exploited to disrupt timely egg maturation. Also this project will analyze follicle/cumulus- and oocyte-derived proteins that control cumulus-oocyte expansion and follicle rupture, and test whether antagonists prevent ovulation and egg release. Project III, "Control of Gamete Transport and Fertilization" tests the hypothesis that estrogen action is essential for normal oviductal and cervical function, such that a selective estrogen receptor modulator (SERM) will disrupt gamete transport, and hence, fertilization. Promising agents discovered in Projects I - III will be tested in the Nonhuman Primate Contraceptive Core for contraceptive efficacy and reversibility. Existing ties with the pharmaceutical industry and OB/GYN, OHSU, will promote translational research relevant to formulating novel ovary/reproductive tract-based contraceptives for women. See individual projects for progress reports and publications.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 开发研究中心针对新型避孕药的发现和开发，这些药物可以防止在月经周期中成人，女性灵长类动物的一个或多个分离性事件。 三个研究项目和一个动物核心利用旧世界（猕猴）猴子生成有关预防卵母细胞受精的方式的新信息和概念证明，因此女性的生育能力。 项目一，“卵母细胞成熟的控制”将解决以下假设：新型卵泡细胞和卵母细胞衍生的蛋白质控制卵母细胞的核和细胞质成熟，并且可以被利用以破坏及时的卵成熟。 该项目还将分析卵泡/卵母细胞衍生的蛋白质，这些蛋白质控制卵母细胞扩张和卵泡破裂，并测试拮抗剂是否防止排卵和卵子释放。 项目III，“对配子运输和受精的控制”检验了雌激素作用对于正常的产卵和宫颈功能至关重要的假设，因此选择性雌激素受体调节剂（SERM）会破坏配子的运输，因此会破坏配子的运输。 在项目I -III中发现的有前途的代理人将在非人类灵长类动物避孕核心中进行避孕功效和可逆性测试。 与制药行业和OB/GYN的现有联系将促进与制定基于新型卵巢/生殖道的妇女避孕药相关的转化研究。有关进度报告和出版物的各个项目。