Neuroimaging and Mentoring in Translational Pain Research

转化疼痛研究中的神经影像学和指导

基本信息

批准号：
9249006
负责人：
SEAN C MACKEY
金额：
$ 18.06万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-05-01 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9249006
关键词：
Acupuncture Therapy Acute Alcohol or Other Drugs use Applications Grants Award Biological Markers Brain Brain imaging Chronic low back pain Clinical Clinical Sciences Cognitive Therapy Collaborations Collection Colorado Data Data Analyses Data Set Decision Making Development Development Plans Doctor of Medicine Doctor of Philosophy Effectiveness Emotions Endowment Functional Magnetic Resonance Imaging Funding Future Generations Genetic Goals Grant Group Meetings Health Individual Interdisciplinary Study Lead Leadership Limbic System Machine Learning Magnetic Resonance Imaging Maintenance Manuscripts Measures Medicine Mentors Mentorship Methods Mid-Career Clinical Scientist Award (K24)National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Drug Abuse Neurobiology Opioid Pain Pain Research Pain management Paper Patient-Focused Outcomes Patients Pelvic Pain Phase Pilot Projects Process Psychophysics Recruitment Activity Registries Reporting Research Research Personnel Research Project Grants Research Training Resources Rest Role Safety Site Societies Structure Substance Use Disorder Substance abuse problem Supervision System Techniques Time Training Translational Research United States National Institutes of Health Universities Wages Work Writing base career career development central pain chronic back pain chronic pain chronic pelvic pain design fibromyalgia pain flexibility interdisciplinary approach mind control mindfulness-based stress reduction multimodality neural correlate neurofeedback neuroimaging next generation novel open source patient oriented research point of care prescription opioid professor programs public health relevance relating to nervous system research study responsible research conduct role model working group

项目摘要

DESCRIPTION (provided by applicant): The primary goals of this K24 competing renewal application are to allow Sean Mackey, M.D., Ph.D. to 1) continue to devote near full time effort to his program of pain and prescription opioid research; and 2) provide high-quality and intensive mentorship of early-career investigators in patient-oriented research (P0R). A K24 renewal will continue to provide Dr. Mackey with the critical protected time for POR and mentoring that would otherwise be spent on administrative and clinical responsibilities. Dr. Mackey is the Redlich Professor and Division Chief of Pain Medicine at Stanford University. Since receiving a K24 award Dr. Mackey has accomplished the major goals of his original application and much more. Dr. Mackey's research plan for this K24 renewal application includes work as a P01 PD to investigate mechanisms of chronic low back pain (CLBP) and four therapies; characterizing the effects of opioids on brain structure in patients with CLBP; expanding his work in neuroimaging based biomarkers (Co-I on R01); continuing role in the NIDDK Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain network; further development, implementation and dissemination of the Stanford-NIH based partnership for an open-source, free health registry (PI). Dr. Mackey's mentoring plan includes training his mentees in: 1) designing and implementing pain research studies; 2) preparing scientific papers and presentations; 3) writing successful grant applications; 4) responsible conduct of research; and 5) successful navigation of the academic process to achieve scientific independence. This mentoring plan will be applied to his direct mentees as well as those he oversees as the PD for his NIDA T32 "Interdisciplinary Research Training in Pain and Substance Use Disorders". Dr. Mackey will accomplish this through a combination of role modeling, individual and group meetings, collaborative mentoring, and integration with Stanford's Clinical and Translational Science Award (CTSA) mentoring program. Dr. Mackey's career development plan includes further training in machine learning approaches for neuroimaging analysis as well as for his health registry; multimodal MRI collection and analysis methods; analysis of large data sets and longitudinal data. With the outstanding resources and collaborations at Stanford and novel projects, the ongoing projects are expected to be either renewed or lead to new directions in pain and substance use research and significantly contribute to our scientific understanding of these disabling conditions. Further, these projects and Dr. Mackey's mentorship will support the need to train the next generation of investigators conducting important pain and substance abuse POR.

描述（由应用程序提供）：此K24竞争续订申请的主要目标是允许Sean Mackey，M.D。，Ph.D。到1）继续致力于他的疼痛和处方阿片类药物研究计划； 2）在以患者为导向的研究（P0R）中提供早期研究人员的高质量和密集的心态。 K24的更新将继续为Mackey博士提供POR的关键保护时间，否则将用于行政和临床责任。 Mackey博士是斯坦福大学的雷德里奇教授兼止痛医学部长。自从获得K24奖以来，Mackey博士实现了他原始申请的主要目标以及更多目标。 Mackey博士针对此K24更新应用的研究计划包括作为P01 PD的工作，以研究慢性下背部疼痛（CLBP）和四种疗法的机制；表征阿片类药物对CLBP患者大脑结构的影响；扩展他在基于神经影像学的生物标志物（R01上的Co-I）中的工作；在慢性骨盆疼痛网络研究的NIDDK多学科方法中的持续作用；开源，自由健康注册中心（PI）的基于斯坦福大学NIH的伙伴关系的进一步发展，实施和传播。麦基博士的心理计划包括培训他的男子：1）设计和实施疼痛研究； 2）准备科学论文和演讲； 3）编写成功的赠款申请； 4）负责任的研究； 5）成功导航了实现科学独立性的学术过程。该指导计划将应用于他的直接男性和他负责的NIDA T32“疼痛和药物使用障碍跨学科研究培训的PD。对于他的健康注册表，多模式的MRI收集和分析方法；对大型数据集和纵向数据的分析。需要训练下一代的调查人员进行重要的痛苦和滥用药物。