Advancing Psychosocial & Biobehavioral Stress Measurement to Understand Aging

促进社会心理

• 批准号: 9391884
• 负责人: Elissa S. Epel
• 金额: $ 10.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9391884
• 关键词: Acute; Address; Adult; Affect; Affective; Aging; Basic Science; Biological; Brain; Chronic; Chronic stress; Cognitive; Collaborations; Comparative Study; Complex; Development; Disease; Documentation; Ecological momentary assessment; Educational workshop; Elderly; Epidemiology; Ethnic Origin; Etiology; Event; Exposure to; Foundations; Gold; Guidelines; Health; Health Promotion; Human; Human Development; Impaired health; Individual Differences; International; Internships; Intervention; Language; Lead; Life; Life Cycle Stages; Life Stress; Link; Longevity; Measurement; Measures; Mental Health; Methods; Monoclonal Antibody R24; Occupations; Onset of illness; Outcome; Paper; Peripheral; Physiological; Physiology; Pilot Projects; Play; Policies; Population Study; Process; Psychological Stress; Psychology; Psychometrics; Psychosocial Stress; Publications; Recruitment Activity; Research; Research Methodology; Research Personnel; Risk Factors; Sampling; Science; Scientist; Services; Shapes; Skin; Social Environment; Socioeconomic Status; Stress; Subgroup; Surveys; Taxonomy; Technology; Validation; Work; base; biobehavior; cognitive function; comparative; critical period; effective intervention; epidemiology study; field study; health disparity; improved; indexing; innovation; interest; member; mortality; multilevel analysis; population based; population health; prevent; psychologic; psychosocial; public health relevance; resilience; response; social; standard measure; study population; theories; tool; validation studies; web site

DESCRIPTION (provided by applicant): There is now large-scale epidemiological evidence that aspects of chronic psychological stress, such as early adversity or job strain, and early life stress, predict earlier disease onset and mortality. Despite documentation of the importance of stress to health, there are several critical barriers that prevent progress in the epidemiological study of stress as a risk factor for disease. Measurement of stress is inherently complex and multi-level (e.g., social, psychological, physiological). There are few agreed upon 'gold standard' measures of stress, hence measurement is often inconsistent and superficial where heterogeneous constructs are conflated. There is also little understanding of the conditions under which stress exposure can promote vulnerability vs. resiliency to disease. Meanwhile, there have been rapid advances in the basic science of stress processes, which have helped to unpack the cognitive and affective components, links to brain and peripheral physiological responses, and richer measures of daily stress - e.g., through ecological momentary assessments using technology to obtain detailed profiles of exposures and contexts. Thus, epidemiological stress science can benefit from a more coherent multilevel model that encompasses better measurement of lifespan exposures and responses, including the social, psychological, and physiological indices of stress that have the greatest impact on health. The proposed R24 will recruit excellent scientists with relevant methods to apply their interests to th advancement of stress measurement across human development, with a focus on how lifespan stress affects health in mid to late life. Aims include: 1) Development of a stress measurement taxonomy, including guidelines for best measurement; 2) Development of a 'toolbox' of short measures of stress that can be used in epidemiological studies of adult aging internationally. These will be drawn from innovative measurement from basic experimental and field research, refinement/shortening of existing measures, and results from comparative validation of promising measures; and 3) Promotion of stress research in epidemiological studies of aging, both through harmonizing existing measures and adding new toolbox measures. This in turn will lead to discoveries that refine the taxonomy and research methodologies. Improved stress measurement offers tremendous opportunities for advancing the field of basic research, enhancing the efficacy of health-promotion interventions and policy.

描述（由申请人提供）：现在有大规模的流行病学证据表明，慢性心理压力的各个方面，例如早期逆境或工作压力，以及早期的生活 压力，预测早期的疾病发作和死亡率。尽管记录了压力对健康的重要性，但仍有一些关键障碍可以防止压力作为疾病的危险因素的流行病学研究进展。压力的测量本质上是复杂且多层的（例如社会，心理，生理）。很少有人同意“黄金标准” 因此，在混合异质构建体的情况下，压力的测量通常是不一致的和表面的。对压力暴露可以促进脆弱性与对疾病的弹性的条件也几乎没有理解。同时，压力过程的基础科学已经取得了迅速的进步，这些科学有助于解开认知和情感成分，与大脑和外围生理反应的联系，以及每日压力的更丰富的衡量方法 - 例如，通过使用技术的生态瞬时评估，使用技术来获得详细的暴露和环境。因此，流行病学压力科学可以从更连贯的多层次模型中受益，该模型包括更好地测量寿命暴露和反应，包括对健康影响最大的压力的社会，心理和生理指标。拟议的R24将采用相关方法招募优秀的科学家，以将其兴趣运用到整个人类发展的压力测量中的发展，重点是寿命压力如何影响中期至后期的健康。目的包括：1）制定压力测量分类法，包括最佳测量指南； 2）开发一个短期应力测量的“工具箱”，可以在国际成人衰老的流行病学研究中使用。这些将从基本的实验和现场研究，现有措施的改进/缩短以及有希望措施的比较验证结果中得出这些衡量。 3）通过协调现有措施和添加新的工具箱措施来促进衰老流行病学研究的压力研究。反过来，这将导致发现分类法和研究方法论的发现。改进的压力测量为促进基础研究领域的领域提供了巨大的机会，增强了健康促进干预和政策的功效。