Seasonal and Hormonal Effects on Auditory Processing

季节和荷尔蒙对听觉处理的影响

基本信息

批准号：
8274668
负责人：
Melissa Lynne Caras
金额：
$ 2.86万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-06-16 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8274668
关键词：
Acoustic Nerve Address Androgen Receptor Area Auditory Auditory Brainstem Responses Auditory system Behavior Birds Brain Stem Breeding Cell Nucleus Cells Cochlear nucleus Code Communication Complex Data Dental crowns Electrodes Estrogen Receptors Exhibits Female Ganglia Goals Gonadal Steroid Hormones Hearing Hormonal Hormone Receptor Hormones Human Immunohistochemistry Implant Individual Label Labyrinth Link Literature Location Mediating Methods Mission Modeling Morphology National Institute on Deafness and Other Communication Disorders Nature Nerve Nerve Fibers Perception Peripheral Physiology Principal Component Analysis Process Production Property Prosencephalon Research Seasons Sensory Series Signal Transduction Songbirds Sparrows Synapses Thalamic structure Work auditory pathway auditory stimulus base extracellular male neural circuit otoacoustic emission postsynaptic presynaptic programs receptor expression research study response statistics steroid hormone

项目摘要

Gambel's white-crowned sparrows are songbirds that breed seasonally. Like many other songbirds, they exhibit dramatic seasonal differences in song behavior, and in the morphology and physiology of the neural circuit underlying song production. Androgenic and estrogenic steroid sex hormones mediate these seasonal changes. While much work has focused on the hormonal mechanisms underlying seasonal plasticity in songbird vocal production, comparatively little work has investigated seasonal and hormonal effects on songbird auditory processing. Preliminary auditory brainstem response (ABR) data demonstrate that breeding condition white-crowned sparrows have significantly increased thresholds and latencies than non-breeding birds; however, a detailed assessment of these effects remains to be accomplished. The focus of my research is to use white-crowned sparrows as a model for further characterizing seasonal and hormonal influences on auditory function. Using extracellular single-unit recording methods, Specific Aim 1 will determine where in the auditory system seasonal differences originate. Specific Aim 2 will identify which hormone receptors mediate these changes by utilizing a variety of hormone treatments, immunohistochemistry and ABR recording. Finally, Specific Aim 3 will determine if seasonal differences observed in the peripheral/brainstem auditory system are conserved in forebrain processing regions.

甘贝尔白冠麻雀是季节性繁殖的鸣禽。与许多其他鸣禽一样，它们在鸣叫行为以及鸣叫神经回路的形态和生理学方面表现出显着的季节性差异。雄激素和雌激素类固醇性激素介导这些季节性变化。虽然很多工作都集中在鸣禽发声季节性可塑性背后的激素机制上，但相对较少的工作研究了季节性和激素对鸣禽听觉处理的影响。初步听觉脑干反应（ABR）数据表明，繁殖状态的白冠麻雀比非繁殖状态的鸟类阈值和潜伏期显着增加；然而，对这些影响的详细评估仍有待完成。我研究的重点是使用白冠麻雀作为模型，进一步表征季节和荷尔蒙对听觉功能的影响。使用细胞外单单元记录方法，特定目标 1 将确定听觉系统季节性差异的起源。具体目标 2 将通过利用各种激素治疗、免疫组织化学和 ABR 记录来确定哪些激素受体介导这些变化。最后，具体目标 3 将确定在外周/脑干听觉系统中观察到的季节性差异是否在前脑处理区域中得到保留。