Enhancing Translational Science via Prospective Investigation
通过前瞻性调查加强转化科学
基本信息
- 批准号:9102996
- 负责人:
- 金额:$ 16.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2013
- 资助国家:美国
- 起止时间:2013-07-01 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:AtlasesAttentionBasic ScienceBehaviorBiologicalBiological MarkersBiologyCancer BiologyCareer ChoiceCaringCessation of lifeCharacteristicsClassificationClear CellClinicalClinical DataClinical ResearchClinical SciencesClinical TrialsComplexDasatinibDataData CollectionData SetDevelopmentDiagnosticDiseaseDoctor of PhilosophyEducationEvaluationEventFaceFacultyFellowshipFunctional ImagingGene ExpressionGenerationsGeneticGenetic MarkersGenomeGenomicsHealthHumanHypoxia Inducible FactorIncidenceInvestigationKidneyKidney NeoplasmsKnowledgeLightLymphomaMalignant NeoplasmsMedical OncologyMentorsMetabolicMethodsMicroRNAsModelingMolecular GeneticsMolecular ModelsMolecular ProfilingMotivationMutationNeoadjuvant TherapyNephrectomyNursing FacultyOrphanOutputPalliative CarePathway interactionsPatient CarePatient-Focused OutcomesPatientsPatternPerfusionPhosphotransferasesPhysiciansPositron-Emission TomographyPreparationPrognostic MarkerPropertyRadiation OncologyRadiology SpecialtyRecurrenceRefractoryRegulationRenal Cell CarcinomaRenal carcinomaResearchResearch ActivityResearch PersonnelResearch Project GrantsResourcesRisk AssessmentRisk ReductionRoleSamplingScientistSeriesServicesShapesSignal PathwaySignal TransductionStagingStudentsTherapeuticTimeTranslational ResearchTumor BurdenUrologic OncologyVHL mutationValidationVascular Endothelial Growth FactorsWorkbench to bedsidebiological systemscancer typecareerchemotherapyclinical decision-makingclinically actionableclinically relevantdesigndisorder riskdisorder subtypedrug developmenteffective therapyfascinatefundamental researchgraduate studenthypoxia inducible factor 1improvedinnovationinsightinterestmRNA Expressionmembermolecular markermolecular modelingmouse modelmultidisciplinaryneoplastic cellnovelnovel strategiesoutcome forecastpatient orientedpatient oriented researchpatient stratificationpredictive markerprogramsprospectiveresearch clinical testingresponserole modeltargeted treatmenttherapeutic developmenttherapy developmenttherapy outcometumortumor heterogeneitytumorigenesis
项目摘要
DESCRIPTION (provided by applicant): Renal cell carcinoma is a cancer with major unmet clinical needs for which the incidence is steadily rising, and which is increasingly becoming a multidisciplinary disease. Our understanding of the underlying genetic and molecular factors which shape the clinical outcomes for patients with this cancer has advanced to a stage where application to clinical decision-making is imperative. An enhanced understanding of the molecular and genetic events which contribute to disease recurrence and death would significantly improve our ability to stratify patients into clinically relevant classes, devise strategies to achieve risk reduction and identify novel methods to treat patients with this cancer.
We have previously identified several important biological features of these cancers through our translational efforts, which are instructional in discriminating the pathways to cancer in the kidney. I propose to extend these features as biomarkers in four projects in various stages of development as vehicles to introduce junior members of our clinical team to the unique potential of prospective investigation. In brief, the four projects are: 1) Prospective biomarker assessment and longitudinal clinical data collection for prognostic biomarker validation. 2) Evaluation of clinical benefit to neoadjuvant treatment with pazopanib prior to nephrectomy, with prospective development of response - predictive biomarkers. 3) Elucidation of the functional relationship of genomic intratumoral heterogeneity with tumor perfusion and metabolic properties using MR-PET. 4) Evaluation of a kinase biomarker expression profile to stratify patients for response to dasatinib. This proposal will provide a series of optimal clinically annotated datasets for developing biological and pharmacological relationships as well as serving as a platform for developing a multidisciplinary cadre of established investigators through the involvement of junior faculty and fellow mentoring relationships. In addition to providing ground-level support fo this endeavor, the support of this proposal will allow me to have the protected time and a platform from which to continue and expand my current patient-oriented research efforts as well as the mentoring efforts of junior faculty, fellows and residents, as well as post-graduate students, focusing on MD-PhD student preparation for the physician- scientist career path. This work will provide key insights to enable drug development, more accurate disease risk assessment, suggest possible therapeutic strategies, and model the biology of common molecular and genetic changes responsible for renal oncogenesis while continuing to build a robust multidisciplinary team. Further, these studies are ideally suited for developing the careers
of junior faculty and clinical trainees, and will serve as the launching point for studies to be implemented by my mentees.
描述(由申请人提供):肾细胞癌是一种癌症,其发病率正在稳步上升,并且越来越成为一种多学科疾病。我们对塑造该癌症患者临床结果的潜在遗传和分子因素的理解已发展到必须应用于临床决策的阶段。对有助于疾病复发和死亡的分子和遗传事件的增强理解将显着提高我们将患者分为临床相关类别的能力,制定策略以降低风险,并确定治疗该癌症患者的新方法。
我们以前已经通过我们的翻译工作确定了这些癌症的几个重要生物学特征,这在区分肾脏的癌症途径方面具有教学性。我建议将这些功能扩展为在开发各个阶段的四个项目中的生物标志物,作为将我们临床团队的初级成员介绍给前瞻性调查的独特潜力。简而言之,这四个项目是:1)预后生物标志物验证的前瞻性生物标志物评估和纵向临床数据收集。 2)在肾切除术之前对新辅助治疗新辅助治疗的临床益处的评估,并有效地发展了反应 - 预测性生物标志物。 3)使用MR-PET阐明基因组内异质性与肿瘤灌注和代谢特性的功能关系。 4)评估激酶生物标志物表达谱,以分层患者对达沙尼的反应。该提案将提供一系列最佳的临床注释数据集,以建立生物学和药理学关系,并作为通过参与初级教师和同胞教师关系的参与来开发既定研究人员的多学科干部的平台。除了提供这项努力的基础支持外,该提案的支持还可以使我拥有受保护的时间和一个平台,可以从中继续并扩大我目前以患者为导向的研究工作,以及初级教师,研究员和居民和居民的指导工作,并专注于MD-PHD学生,以专注于MD-PHD学生为物理学的职业发展。这项工作将提供关键的见解,以实现药物开发,更准确的疾病风险评估,提出可能的治疗策略,并模拟导致肾脏肿瘤发生的常见分子和遗传变化的生物学,同时继续建立一个强大的多学科团队。此外,这些研究非常适合发展职业
初级教师和临床学员的工作,将作为我的受训者实施研究的发射点。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WENDY KIMRYN RATHMELL其他文献
WENDY KIMRYN RATHMELL的其他文献
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{{ truncateString('WENDY KIMRYN RATHMELL', 18)}}的其他基金
VIMORTP (Vanderbilt Integrated Molecular Oncology Research Training Program)
VIMORTP(范德比尔特综合分子肿瘤学研究培训计划)
- 批准号:
10225434 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
VIMORTP (Vanderbilt Integrated Molecular Oncology Research Training Program)
VIMORTP(范德比尔特综合分子肿瘤学研究培训计划)
- 批准号:
9981681 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
VIMORTP (Vanderbilt Integrated Molecular Oncology Research Training Program)
VIMORTP(范德比尔特综合分子肿瘤学研究培训计划)
- 批准号:
10449242 - 财政年份:2018
- 资助金额:
$ 16.29万 - 项目类别:
Methyltransferase Contributions to Genomic Stability and Cancer
甲基转移酶对基因组稳定性和癌症的贡献
- 批准号:
9130344 - 财政年份:2016
- 资助金额:
$ 16.29万 - 项目类别:
Methyltransferase Contributions to Genomic Stability and Cancer
甲基转移酶对基因组稳定性和癌症的贡献
- 批准号:
9518574 - 财政年份:2016
- 资助金额:
$ 16.29万 - 项目类别:
Enhancing Translational Science via Prospective Investigation
通过前瞻性调查加强转化科学
- 批准号:
8692688 - 财政年份:2013
- 资助金额:
$ 16.29万 - 项目类别:
Enhancing Translational Science via Prospective Investigation
通过前瞻性调查加强转化科学
- 批准号:
8883122 - 财政年份:2013
- 资助金额:
$ 16.29万 - 项目类别:
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