Proton MRI to measure lung ventilation and perfusion

质子 MRI 测量肺通气和灌注

• 批准号: 9096209
• 负责人: GORDON KIM PRISK
• 金额: $ 90.87万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9096209
• 关键词: Address; Affect; Air; Animal Model; Animals; Biological Markers; Biomedical Engineering; Blood flow; Breathing; Chronic Obstructive Airway Disease; Clinical Research; Clinical Trials; Communities; Computer Simulation; Contrast Media; Dimensions; Discipline of Nuclear Medicine; Disease; Dourine; Environmental air flow; Evolution; Exposure to; Functional Imaging; Functional Magnetic Resonance Imaging; Future; Gases; Goals; Gold; Grant; Health; Health Care Research; Healthcare; Heterogeneity; Human; Image; Imaging Techniques; Injection of therapeutic agent; Ionizing radiation; Lung; Lung diseases; Magnetic Resonance Imaging; Maps; Measurement; Measures; Methodology; Microspheres; Modeling; Morphologic artifacts; Noble Gases; Pattern; Perfusion; Phenotype; Physiologic pulse; Physiological; Physiology; Property; Protons; Pulmonary Gas Exchange; Radiation; Regional Perfusion; Research; Research Personnel; Research Technics; Resolution; Series; Source Code; Spatial Distribution; Structure; Techniques; Therapeutic Intervention; Time; Universities; Validation; Ventilation-Perfusion Ratio; Washington; X-Ray Computed Tomography; base; clinical application; clinically relevant; computerized data processing; density; foot; imaging modality; improved; lung imaging; pre-clinical; programs; research study; sound; standard measure; tool; validation studies

DESCRIPTION (provided by applicant): In comparison to other imaging modalities such as computerized tomography and nuclear medicine techniques, quantitative functional magnetic resonance imaging (MRI) of the human lung is relatively poorly developed. These MRI techniques are not limited by exposure to ionizing radiation or contrast injection and thus open the door to unlimited repeated studies, and offer the possibility of new fields such as temporal imaging. The long-term objective of this program is to develop and establish quantitative functional proton MRI in the human lung as a readily available means of providing regional information on perfusion, ventilation and gas exchange that is physiologically and clinically relevant. Techniques we have developed allow us to quantitatively measure the spatial distributions of lung density (a direct measure of air content), pulmonary blood flow, and specific ventilation. Together these techniques permit us to quantitatively map ventilation- perfusion ratio (V? A/Q?), which uniquely determines pulmonary gas exchange, with a spatial resolution that is close to the scale of the functional gas exchange unit of the human lung. The overall goal of the first five years of this Bioengineering Research Partnership (BRP) is to make these research techniques translatable to the wider research community so that they may be used as biomarkers in research studies and in clinical trials, with a future goal of clinical applicability To do so, these techniques need to: a) have their physiological interpretation strengthened to provide a rigorous basis for interpretation of the results they produce; b) be further developed into efficient and accessible techniques for clinical studies; and c) be subjected to validation studies to prove their applicability for clinical studies. To these ends we propose a coordinated series of studies that will: 1) use highly anatomically-realistic in-silico modeling to place the physiological interpretation of all imaging modalities on a sound footing; 2) validate imaging of perfusion, ventilation and V A/Q by comparing with injected and inhaled microsphere measurements in a pre-clinical large animal model; 3) cross- validate imaging of V A/Q in humans with quantitative measures of VA/Q obtained from the gold-standard non-imaging approach of the multiple inert gas elimination technique, both in the normal and diseased lung; and 4) optimize the current MR methodology and expand the repertoire of functional lung imaging with improved techniques. Completion of this BRP will result in deliverables of an accessible suite of validated quantitative functional MR lung imaging methods for use on commercially available scanners to measure density, perfusion, ventilation, and ventilation-perfusion ratio.

描述（由申请人提供）：与其他成像方式（例如计算机断层扫描和核医学技术）相比，人类肺的定量功能磁共振成像（MRI）相对较差。这些MRI技术不受接触电离辐射或对比度注入的限制，因此为无限重复研究打开了大门，并提供了诸如时间成像之类的新领域的可能性。该计划的长期目的是在人肺中开发和建立定量功能质子MRI，作为提供有关在生理和临床上相关的灌注，通风和气体交换的区域信息的一种可用方法。我们开发的技术使我们能够定量测量肺密度的空间分布（直接衡量空气含量），肺血流和特定 通风。这些技术一起允许我们定量绘制通风灌注比 （v？a/q？），哪个唯一决定肺气交换，其空间分辨率接近人类肺功能性气体交换单元的尺度。这种生物工程研究伙伴关系（BRP）的头五年的总体目标是使这些研究技术可以翻译成更广泛的研究社区，以便它们可以用作研究和临床试验中的生物标志物，并在临床试验中将其作为生物标志物，并具有临床适用性的未来目标。 b）进一步发展为临床研究的有效且可访问的技术； c）接受验证研究以证明其适用于临床研究。在这些目的中，我们提出了一系列协调的研究，该研究将：1）使用高度解剖学现实的内部模型来将所有成像方式的生理解释放在声音基础上； 2）通过与临床前大动物模型中注入和吸入的微球测量值进行比较，从而验证灌注，通风和V A/Q的成像； 3）在人类中对V A/Q进行的跨验证成像，并通过在正常肺和患病的肺中从多重惰性气体消除技术的金标准非成像方法获得的VA/Q进行定量测量。 4）优化当前的MR方法，并通过改进的技术扩展功能性肺成像的曲目。该BRP的完成将导致可访问的可访问套件的可访问的定量功能性MR肺成像方法用于市售扫描仪，以测量密度，灌注，通风和通风 - 灌注率。