A New England Enrollment Center for PMI Cohort Program

新英格兰 PMI 队列计划招生中心

• 批准号: 9355397
• 负责人: ELIZABETH W KARLSON
• 金额: $ 121.12万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-27 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355397
• 关键词: Adopted; Adult; Ambulatory Care; Area; Boston; Caring; Catchment Area; Censuses; Clinical Data; Collaborations; Collection; Complement; Consent; Data; Data Reporting; Electronics; Enrollment; Evaluation; Future; Geography; Goals; Health Personnel; Health Status; Health system; Healthcare Systems; Information Technology; Life; Medical center; Minority; Names; Network-based; New England; PMI cohort; Participant; Patient Recruitments; Patients; Performance; Persons; Philosophy; Physicians; Policies; Population; Precision Medicine Initiative; Procedures; Process; Protocols documentation; Recontacts; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Sampling; Services; Shipping; Ships; Structure; Surveys; Target Populations; Teaching Hospitals; Technology; Testing; Universities; base; biobank; clinical infrastructure; cohort; demographics; innovation; medical schools; meetings; programs; sample collection; transmission process; volunteer

We propose the creation of “Precision Medicine Initiative New England” (PMI-NE), an enrollment center that encompasses two leading health care provider (HPO) organizations: Partners HealthCare System (PHS) and Boston Medical Center (BMC), the primary teaching hospital of Boston University School of Medicine (BU). We will provide essential geographic diversity in the Northeast Census Region of the US by complementing the Middle Atlantic Division (NJ, NY, and PA; covered in the Columbia and Pittsburgh PMC HPOs) with the New England Division (CT, ME, MA, NH, RI, and VT). Together, PHS and BMC serve a catchment area of 14.4 million people including a large and diverse proportion of the 4.4 million living in the greater Boston area, large portions of the New England population, and a worldwide referral base. Over a five-year period, PHS and BMC delivered outpatient care to 2,253,618 patients with 863,429 (38%) meeting our recruitment target population criteria. Our organizations have a long history of collaboratively producing and using common, open-standards information technology (IT) that leverages the health care system for discovery and has been adopted nationally and internationally. PHS has already implemented brisk recruitment of patients (more than 46,000 to date, 2,200 consented per month) into the PHS Biobank with many key components of PMI including broad consent, linkage to EMR, electronic surveys, and recontact. In large cutting-edge projects, we have successfully engaged participants as partners in research and sustained longitudinal engagement using traditional as well as innovative IT approaches. As such, we have already developed and tested the IT and clinical infrastructures that will be central to achieving PMI milestones and can rapidly adopt procedures developed by the PMI Consortium. We have an extensive, successful track record of collaboration and contributions to large-scale national networks, including the PCORNet Clinical Data Research Network based at Harvard (named “SCiLHS”) in which PHS and BMC-BU collaborate, eMERGE, and many others (see Past Performance). Our team, comprising diverse stakeholders (physicians, researchers, IT leaders, participants) will cohere to enroll 10,000 patients (46% minority) in service of the PMI Cohort Program (PMI-CP). In the sections that follow, we describe our approach to establishing our PMI-NE HPO and our contributions to the PMI Consortium. We describe well-defined milestones and metrics over the 12-month period of performance.

我们建议创建“ Precision Medicine Initiative New England”（PMI-NE），这是一个入学中心 包括两个领先的医疗保健提供者（HPO）组织：合作伙伴医疗保健系统（PHS）和 波士顿医学中心（BMC），波士顿大学医学院（BU）的初级教学医院。我们 通过完成 中大西洋师（新泽西州，纽约和PA；哥伦比亚和匹兹堡PMC HPO覆盖） 英格兰分区（CT，ME，MA，NH，RI和VT）。 PHS和BMC一起提供14.4的集水区域 数百万人包括居住在大波士顿地区的440万人中的很大一部分 新英格兰人口的一部分和全球推荐基础。在五年内，PHS和BMC 向2,253,618例患者提供门诊护理，其中863,429（38％）达到我们的招聘目标 人口标准。我们的组织在共同生产和使用常见的历史上有很长的历史 利用医疗保健系统进行发现的开放标准信息技术（IT） 在国内和国际上采用。 PHS已经实施了对患者的轻快招募（超过 迄今为止的46,000，每月2,200份同意 广泛的同意，与EMR的联系，电子调查和重新连接。在大型尖端项目中，我们有 成功地参与参与者，作为研究的合作伙伴，并持续纵向参与 传统和创新的IT接近。因此，我们已经开发并测试了IT和 对于实现PMI里程碑至关重要的临床基础设施，可以快速采用程序 由PMI财团开发。我们拥有合作的广泛，成功的记录和 对大型国家网络的贡献，包括基于PCORNET临床数据研究网络 在哈佛大学（命名为“ Scilhs”），其中PHS和BMC-BU合作，Emerge和许多其他人（请参阅过去 表现）。我们的团队完成了潜水员利益相关者（医师，研究人员，IT领导者，参与者） 将在PMI队列计划（PMI-CP）服务中招募10,000名患者（46％的少数民族）。在 随后的部分，我们描述了建立PMI-NE HPO的方法以及我们对 PMI财团。我们在12个月的性能中描述了定义明确的里程碑和指标。