Laboratory Sciences Core (Core D)

实验室科学核心（核心 D）

• 批准号: 9322044
• 负责人: Savita Pahwa
• 金额: $ 49.17万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9322044
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Administrative Supplement; Adopted; Area; Awareness; Back; Bioinformatics; Biological Assay; Charge; Clinical; Collaborations; Communities; Comprehensive Cancer Center; Consultations; Contract Services; Core Facility; Data; Development; Distant; Education; Emerging Communicable Diseases; Ensure; Equipment; Event; Flow Cytometry; Fostering; Funding; Gene Expression; Genomics; Goals; Grant; Growth; HIV; Human; Immunologics; Immunology; Immunology procedure; Infusion procedures; Institutes; International; Investigation; Laboratories; Leadership; Letters; Licensing; Mentors; Mentorship; Mission; Modeling; Molecular Virology; Natural Immunity; Needs Assessment; Outcome; Phase; Plasma; Policies; Procedures; Publications; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Priority; Research Support; Resources; Science; Scientific Advances and Accomplishments; Services; Site; Standardization; Students; Systems Biology; Tissues; Training; United States National Institutes of Health; Universities; Vaccine Therapy; Vaccines; Viral reservoir; adaptive immunity; behavioral/social science; cancer genomics; cytokine; discount; enzyme linked immunospot assay; gene therapy; improved; innovation; macrophage; meetings; monocyte; new technology; novel; prevent; symposium; synergism; tool; transcriptomics; virology

Laboratory Sciences Core (D) Project Summary/Abstract In this renewal application for a third cycle of funding, Core D of the Miami CFAR at the University of Miami (UM) remains under the direction of Dr Savita Pahwa with a new co-director, Dr Sion Williams who is also the Director of the Oncogenomics Core at the Sylvester Comprehensive Cancer Center at UM. Since transitioning from a DCFAR into a full CFAR in 2012, Core D has evolved into an integrated, centralized Laboratory Core that will embrace innovation, meet the diverse laboratory needs of investigators involved in HIV/AIDS research and draw new investigators into the field. It will provide immunologic, virologic and genomics services through an easily accessible “one stop shop” mechanism, foster technological advances all the while remaining cognizant of the HIV/AIDS research priorities of the NIH. Core D will leverage resources within and outside UM, synergize with other Cores and scientific areas of research (SAR) and engage in inter-CFAR collaborations to reach its goals. Yearly reviews of Core utilization and needs assessment are important tools for ensuring the Core's efficiency and economy of scale. The Specific Aims of Core D are as follows: Aim 1, to provide specialized immunologic assays in innate and adaptive immunity in its Immunology Sub-Core. This Sub-Core, led by Dr Pahwa with assistance from Dr Pallikkuth will improve existing assays, develop new ones, and stimulate new research in synergy with the Genomics and Virology Sub-Cores. Aim 2, to provide access to the Genomics Sub-Core for a wide variety of gene expression studies and to provide advanced HIV-focused bioinformatics support through an innovative partnership with Case Western Reserve University (CWRU) CFAR. Aim 3, to provide specialized virology assays, viral reservoir analysis and elutriated human monocytes and macrophages in its Virology Sub- Core, led by Dr Stevenson. This Sub-Core will facilitate HIV cure research and investigations of cellular and tissue HIV reservoirs in collaboration with the Immunology and Genomics Sub-Cores. Aim 4, to provide education, mentoring, consultation, training and assistance as needed for laboratory assays to pilot grant awardees and bring awareness of technologic and scientific advances to all CFAR Core D users, promote inter- CFAR collaborations, interact with scientific areas of research (SAR), develop and abide by policies and procedures. Accomplishments of Core D in the past 4 years include innovation in leveraging resources, establishing a productive partnership with the new UM Institute for AIDS and Emerging Infectious Diseases (IAEID), inter-CFAR collaborations, acquisition of new equipment, development of new assays, and regional and distant extension including that to international sites. Core D will serve as a valuable resource that provides investigative tools and mentoring support beyond that which is available through routine grant mechanisms.

实验室科学核心 (D) 项目摘要/摘要 在第三轮资助的续签申请中，迈阿密大学 (UM) 的迈阿密 CFAR 核心 D 仍然由 Savita Pahwa 博士和新任联合主任 Sion Williams 博士（兼任主任）领导 自从从一名医师转变为密歇根大学西尔维斯特综合癌症中心的肿瘤基因组学核心。 2012 年 DCFAR 转变为完整的 CFAR，Core D 已发展成为集成的集中式实验室核心，将 拥抱创新，满足参与艾滋病研究的研究者多样化的实验室需求，并绘制 它将通过简单的方式向该领域的新研究人员提供免疫学、病毒学和基因组学服务。 无障碍的“一站式”机制，始终促进技术进步，同时保持对 NIH 的艾滋病毒/艾滋病研究重点将利用 UM 内外的资源，与 其他核心和科学研究领域 (SAR)，并参与 CFAR 之间的合作以实现其目标。 每年对核心利用率和需求评估进行审查是确保核心效率的重要工具 核心D的具体目标如下： 目标1，提供专业的免疫学。 该子核心由 Pahwa 博士领导，负责先天性和适应性免疫的检测。 Pallikkuth 博士的协助将改进现有的检测方法、开发新的检测方法并刺激新的研究 与基因组学和病毒学子核心的协同作用，目标 2，为基因组学子核心提供访问权限。 广泛的基因表达研究，并通过以下方式提供先进的以艾滋病毒为重点的生物信息学支持 与凯斯西储大学 (CWRU) CFAR 建立创新合作伙伴关系，目标 3，提供专业化服务。 其病毒学子项目中的病毒学检测、病毒库分析以及淘析人类单核细胞和巨噬细胞 核心，由史蒂文森博士领导，该子核心将促进艾滋病毒治疗研究和细胞和研究。 与免疫学和基因组学子核心合作的组织 HIV 储存库，以提供。 实验室分析所需的教育、指导、咨询、培训和援助以试点拨款 获奖者，让所有 CFAR Core D 用户了解技术和科学进步，促进相互交流 CFAR 合作，与科学研究领域 (SAR) 互动，制定并遵守政策和 过去 4 年核心 D 的成就包括利用资源的创新、 与新成立的密歇根大学艾滋病和新发传染病研究所建立富有成效的合作伙伴关系 (IAEID)、CFAR 间合作、购买新设备、开发新检测方法以及区域和 远程扩展（包括国际站点）将作为提供宝贵资源。 调查工具和指导支持超出了常规拨款机制所能提供的范围。