On the road to recovery: building Liberia's clinical and epidemiological research capacity to respond to emerging infectious diseases

走上复苏之路：建设利比里亚应对新发传染病的临床和流行病学研究能力

• 批准号: 9438657
• 负责人: CHRISTINA P LINDAN
• 金额: $ 5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-08 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9438657
• 关键词: Address; Africa South of the Sahara; Area; Biometry; California; Clinical Investigator; Clinical Research; Collaborations; Communicable Diseases; Conduct Clinical Trials; Democratic Republic of the Congo; Disease Outbreaks; Ebola Vaccines; Ebola virus; Educational Status; Emergency Situation; Emerging Communicable Diseases; Enrollment; Epidemiology; Faculty; Funding; Goals; Health; Health Professional; Health Resources; Health Sciences; Human Resources; Infectious Diseases Research; International; Investments; Liberia; Liberian; Los Angeles; Master' s Degree; Mentors; National Institute of Allergy and Infectious Disease; Postdoctoral Fellow; Process; Public Health; Public Health Schools; Recording of previous events; Recovery; Research; Research Methodology; Research Personnel; Research Training; San Francisco; Scientist; Therapeutic; Training; Training Programs; Universities; Virus Diseases; base; epidemiology study; experience; global health; implementation science; investigator training; response

PROJECT SUMMARY/ABSTRACT The recent and devastating Ebola outbreak exposed the need for greater investment in health and human resources in Liberia. Supported by the National Institute of Allergy and Infectious Diseases (NIAID), the Liberian-U.S. Partnership for Research on Ebola Virus (PREVAIL) was developed as an emergency, collaborative research endeavor to conduct clinical trials for Ebola vaccines and therapeutics to help end the suffering from Ebola virus infection. Although the 2013-2016 Ebola outbreak is over, the history of 33 prior Ebola outbreaks tells us that we must continue to prepare. The University of California, San Francisco (UCSF), in collaboration with the University of Liberia (UL), and the University of California, Los Angeles (UCLA), will develop and implement a rigorous training program in clinical and epidemiological research methods for Liberian investigators and health professionals. The primary aim of training is to build the capacity of Liberians to become independent clinical investigators who can successfully implement high-quality clinical and epidemiologic research addressing key areas of importance in Ebola virus and other emerging infectious diseases. The eventual goal is to enable UL to support its own Master's (MS) Degree in Clinical Research by having nurtured and mentored a core group of well-trained investigators who can in turn become leaders in their field. Specifically, we will enroll Liberian health professionals in UCSF's program Training in Clinical Research (TICR) that provides rigorous training in clinical research, epidemiology, biostatistics, implementation science and analysis of original research, and confers a two-year MS Degree in Clinical Research. The degree requires practical research training that will be performed in collaboration with PREVAIL. PREVAIL scientists will also co-mentor trainees along with UCSF and UCLA faculty. The School of Public Health at UCLA brings many years of experience with emerging infectious disease research and training in the Democratic Republic of Congo. The training plan is based on over two decades of experience at UCSF's Global Health Sciences and the Department of Epidemiology & Biostatistics, in training international investigators, post-doctoral scholars, and junior faculty. In addition to providing Master's level training, we will also offer advanced training in how to be a successful mentor, which is critical to nurturing junior investigators, but is rarely formally supported as part of the academic or research culture in sub-Saharan Africa. This D71 application describes the planning process for developing a Global Infectious Disease Research Training Program (D43).The D43- funded training will strengthen the capacity of scientists and health research professionals in Liberia to conduct independent, high-quality infectious disease epidemiologic and clinical research relevant to a successful public health response to emerging infectious diseases.

项目概要/摘要 最近毁灭性的埃博拉疫情爆发暴露了加大对健康和人类投资的必要性 利比里亚的资源。在美国国家过敏症和传染病研究所 (NIAID) 的支持下， 利比里亚-美国埃博拉病毒研究伙伴关系（PREVAIL）是作为紧急情况而制定的， 合作研究致力于开展埃博拉疫苗和治疗方法的临床试验，以帮助结束埃博拉疫情 患有埃博拉病毒感染。尽管2013-2016年埃博拉疫情已经结束，但此前的33次埃博拉疫情历史 埃博拉疫情告诉我们，我们必须继续做好准备。加州大学旧金山分校 （UCSF）与利比里亚大学（UL）和加州大学洛杉矶分校合作 （加州大学洛杉矶分校）将制定并实施严格的临床和流行病学研究培训计划 利比里亚调查人员和卫生专业人员的方法。培训的首要目的是能力建设 的利比里亚人成为能够成功实施高质量临床的独立临床研究人员 和流行病学研究，解决埃博拉病毒和其他新出现的传染病的关键领域 疾病。最终目标是使 UL 能够通过以下方式支持其自己的临床研究硕士学位 (MS)： 培养和指导了一批训练有素的调查人员，他们反过来可以成为领导者 他们的领域。具体来说，我们将招收利比里亚卫生专业人员参加加州​​大学旧金山分校的临床培训项目 研究 (TICR)，提供临床研究、流行病学、生物统计学、实施方面的严格培训 原始研究的科学和分析，并授予两年制临床研究硕士学位。学位 需要与 PREVAIL 合作进行实际研究培训。战胜科学家 还将与加州大学旧金山分校和加州大学洛杉矶分校的教师一起共同指导学员。加州大学洛杉矶分校公共卫生学院带来 在民主共和国拥有多年新发传染病研究和培训经验 刚果。该培训计划基于加州大学旧金山分校全球健康科学二十多年的经验 和流行病学与生物统计学系，培训国际研究人员、博士后 学者和初级教师。除了提供硕士水平的培训外，我们还将提供高级培训 如何成为一名成功的导师，这对于培养初级研究者至关重要，但很少被正式提及 作为撒哈拉以南非洲学术或研究文化的一部分提供支持。此 D71 应用程序描述了 制定全球传染病研究培训计划 (D43) 的规划流程。D43- 资助的培训将加强利比里亚科学家和卫生研究专业人员进行 与成功公众相关的独立、高质量的传染病流行病学和临床研究 对新出现的传染病的健康反应。