Hospital Admissions & Emergency Room Visits in Adults Associated with Influenza C

医院入院

基本信息

批准号：
9252833
负责人：
HELEN Keipp TALBOT
金额：
$ 1.75万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-15 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9252833
关键词：
15 year old 2 year old Accident and Emergency department Acute Acute respiratory infection Admission activity Adult Age-Years Ambulatory Care Facilities Antibodies Antigens Caring Case Study Centers for Disease Control and Prevention (U.S.)Cessation of life Child Childhood Clinic Clinical Clinical Data Clinics and Hospitals Common Cold County Data Data Collection Databases Detection Diagnosis Diagnostic Diagnostic Procedure Disease Elderly Emergency department visit Enrollment Epidemiology Etiology Health Health Care Visit Healthcare Hospitalization Hospitals Human Human Metapneumovirus Immune response Immunocompromised Host Infection Influenza Influenza A virus Influenza B Virus Influenza C Virus Influenza vaccination Japan Life Lower respiratory tract structure Lung diseases Medical Modality Morbidity - disease rate Nigerian Nose Outpatients Patients Performance Persons Pharyngeal structure Pneumonia Polymerase Chain Reaction Population Positioning Attribute Prevention Prevention strategy Questionnaires Recurrence Research Research Design Respiratory Signs and Symptoms Respiratory Tract Diseases Respiratory syncytial virus Role Sampling Seasons Serum Signs and Symptoms Specimen Surveillance Program Swab Symptoms Tennessee Testing Time Vaccination Viral Virus aged base burden of illness cost effective disorder prevention experience high risk hospital admission rate influenza virus vaccine instrument mortality pandemic disease pathogen population based prevent programs prospective repository respiratory respiratory virus treatment strategy vaccine effectiveness

项目摘要

DESCRIPTION (provided by applicant): Despite advances in diagnostic techniques, only 39-75% of episodes of respiratory illness in well-designed studies have an etiology identified. The introduction of polymerase chain reaction (PCR) has helped identified viral pathogens that were previously unidentified due to the poor performance of rapid antigen and culture diagnostics in older adults with influenza and respiratory syncytial virus being two of the most common viral etiologies. Unfortunately, without known etiologies, treatment and prevention strategies are missing. Hence more research is needed to identify pathogens associated with influenza-like illness and pneumonia. One potential pathogen is Influenza C. Influenza C originally called, the "1233 aberrant strain" was discovered in March 1947 during routine surveillance for influenza. One influenza C challenge study done in young healthy adults, described the resulting illness to be similar to the common cold, but data is unavailable who are older and sick. Due to lack of comprehensive studies in influenza C, there is not a good description of the clinical picture of influenza C in adults, nor have any population based rates been calculated. If influenza C causes a significant number of medically attended illness including hospitalizations inclusion of influenza C in the adult vaccination program may prevent morbidity and mortality. Information on adults with respiratory symptoms during the past six influenza seasons has been prospectively collected to determine rates of hospital admissions and to perform yearly case-positive, control-negative influenza vaccine effectiveness studies. The surveillance began in November of 2006 and was completed May 2012. Recruitment began yearly in November in ended in April with the exception of the pandemic where surveillance was continuous from November 2008 through May 2010. Patients were approached if they presented with a respiratory illness and for each participating subject, both a nasal and a throat swab sample were obtained for RT- PCR. Patient questionnaires and chart review captured CDC-defined high risk conditions, symptoms, and vaccinations. Using this data we will be able to accomplish the following aims. Specific Aims: 1. Test specimens for influenza C from a population-based sample of adults =50 years of age with health care visits for acute respiratory illness prospectively enrolled over 6 years. 2. Define the clinical and demographic features of illness associated with influenza C compared with influenza A and B and other respiratory viruses 3. Estimate rates of hospitalizations associated with influenza C among adults =50 years of age.

描述（由适用提供）：尽管诊断技术取得了进步，但在精心设计的研究中，只有39-75％的呼吸道疾病发作已经确定了病因。聚合酶链反应（PCR）的引入已帮助鉴定出由于抗原快速抗原和培养诊断的性能较差而在患有影响力的老年人和呼吸道综合病毒的情况下，这些病毒病原体是未识别的，这是两种最常见的病毒病因。不幸的是，没有已知的病因，治疗和预防策略就缺失了。因此，需要进行更多的研究来识别与影响Za样疾病和肺炎相关的病原体。一种潜在的病原体是流感C.流感C.最初称为“ 1233异常菌株”，于1947年3月在常规监视造成影响力的情况下发现。一项在年轻健康成年人中进行的一项影响力的挑战研究描述了所致的疾病与普通感冒相似，但是数据不可用，年龄较大又生病。由于缺乏影响力C的全面研究，对成人影响的临床表现没有很好的描述，也没有计算任何基于人群的率。如果影响力C引起大量医学参加的疾病，包括住院治疗在成人疫苗接种计划中包括影响力，可能会阻止发病率和死亡率。在过去的六个影响下，已经收集了有关呼吸道症状的成年人的信息，以确定住院率并进行年度病例阳性的，对照负面影响疫苗有效性研究。监视始于2006年11月，于2012年5月完成。招聘于4月的11月开始，除了大流行外，从2008年11月至2010年5月进行监视。如果患者出现呼吸道疾病，则接触了患者，并且为每种参与的主题（包括NASASAL和喉咙羊皮样本）获得了呼吸疾病。患者问卷和图表评估捕获了CDC定义的高风险状况，症状和疫苗接种。使用这些数据，我们将能够实现以下目标。具体目的：1。从基于人群的成年人样本= 50岁的基于人群的样本的测试标本，急性呼吸疾病的医疗访问预期在6年内被预期入学。 2。与影响力和其他呼吸道病毒相比，定义与影响力C的影响相关的疾病的临床和人口特征3。成人= 50岁的成年人中与影响力相关的住院率估计率。