Effectiveness of the Influenza Vaccine in the Aging Population

流感疫苗对老年人群的有效性

基本信息

批准号：
8417869
负责人：
HELEN Keipp TALBOT
金额：
$ 31.98万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-01 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8417869
关键词：
Activities of Daily Living Acute Address Adult Age Age-Years Aging Applications Grants Caring Case-Control Studies Cessation of life Clinical Comorbidity Data Data Collection Data Set Databases Diagnosis Drug Formulations Effectiveness Elderly Event Hospitalization Immune Immune response Immune system Individual Influenza Influenza vaccination Laboratories Licensing Link Lung Measurement Measures Medical Medical Records Methodology Methods Molecular NIH Program Announcements Observational Study Outcome Participant Patients Persons Population Predisposition Prevention Proteins Questionnaires Research Research Design Research Personnel Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Risk Sampling Seasons Subunit Vaccines Testing United States Vaccinated Vaccination Vaccines Viral Vaccines Virion Virus Work administrative database age group aging population case control design frailty indexing influenza virus vaccine instrument manufacturing process mortality prevent prospective public health relevance respiratory respiratory virus response senescence vaccine effectiveness

项目摘要

DESCRIPTION (provided by investigator): This study application is a secondary analysis of an existing database in response to the Program Announcement, PA-09-265: Secondary Analyses of Existing Data Sets and Stored BioSpecimens to Address Clinical Aging Research Questions (R01) to determine influenza vaccine effectiveness in older adults. Recent work has shown that more is needed to be known about influenza vaccine effectiveness in older adults and the methodology used to determine that vaccine effectiveness. This database is an accumulation of three studies that prospectively tested older adults for influenza. This data will be used to determine if the current methodology of test-negative controls will actually control for the bias of frailty, will determine vaccine effectiveness in the very old, and will explore if vaccne manufacturing process impacts effectiveness.

描述（研究人员提供）：本研究应用是对响应计划公告的现有数据库的次要分析，PA-09-265：对现有数据集和存储生物测量的次要分析，以解决临床老化研究问题（R01），以确定老年人的流感疫苗效率。最近的工作表明，关于老年人的流感疫苗有效性以及用于确定疫苗有效性的方法需要了解更多。该数据库是三项研究的积累，这些研究前瞻性地测试了老年人的流感。这些数据将用于确定当前测试阴性控制的方法是否会真正控制脆弱的偏见将确定非常旧的疫苗有效性，并将探索疫苗制造工艺是否影响有效性。