Core A: Administration and Bioanalysis Core

核心 A：管理和生物分析核心

• 批准号: 8904707
• 负责人: ROBERT TARRAN
• 金额: $ 17.69万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-19 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8904707
• 关键词: Administrator; Advisory Committees; Asthma; Bioinformatics; Biology; Biometry; Bronchoalveolar Lavage; Budgets; Cell Culture Techniques; Chronic Obstructive Airway Disease; Communication; Computer Assisted; Contracts; Cystic Fibrosis; Doctor of Philosophy; Ecology; Educational Curriculum; Elements; Ensure; Environmental Engineering technology; Environmental Medicine; Epithelial Cells; Family; Financial Activity; Genes; Goals; Grant; Guidelines; Human; Human Resources; Human Rights; Immunology; Individual; Interdisciplinary Study; Leadership; Lung; Manuscripts; Medicine; Microbiology; Modeling; Monitor; Names; Obstructive Lung Diseases; Outpatients; Pathogenesis; Patients; Pediatrics; Preparation; Principal Investigator; Problem Solving; Progress Reports; Protocols documentation; Publications; Pulmonary Cystic Fibrosis; Quality Control; Recruitment Activity; Research; Research Personnel; Resources; Schedule; Services; Smoke; Sputum; Study Subject; System; TNFRSF5 gene; Testing; Time; Toxicology; Translational Research; United States National Institutes of Health; Universities; base; cost; design; experience; human subject; medical schools; meetings; mouse model; professor; programs; success; text searching; tobacco exposure; treatment center

The Administrative Core will provide (1) professional and (2) administrative functions to the Program ' Project. 1) Professional Component The professional component is designed to monitor the overall progress ofthe TCORS P50, solve problems as they arise, effect quality control, and provide direction for future research. Drs. Tarran and Doerschuk will provide this support to the Core. They will chair weekly meetings with Project and Core Leaders to ensure smooth, coordinated functioning of the projects and to develop new research directions. This function will be coordinated with meetings of the Advisory Committee. The Advisory Committee has been named and consists of: 1) David Peden, MD, Professor of Pediatrics, Medicine & Microbiology/ Immunology, Director ofthe UNC School of Medicine's Center for Environmental Medicine, Asthma and Lung Biology; 2) James Swenberg, PhD, Kenan Distinguished Professor of Environmental Sciences & Engineering; former Director ofthe Curriculum in Toxicology and 3) Richard Boucher, MD, Executive Associate Dean for Translational Research, Distinguished Professor of Medicine, Director of the Cystic Fibrosis/Pulmonary Research and Treatment Center and an expert on obstructive lung diseases. In addition, Drs. Tarran and Doerschuk will chair a monthly administrative luncheon that is designed to monitor P50 personnel and budgetary matters and will monitor the Cores to ensure adequate support for the Projects. This Core will also be the interface with administrators of different departments and divisions within UNC as well as the University Office of Contracts and Grants. 2) Administrative Component a. Budgetary and Programmatic Support: The administrative component will provide the support services required to assure the smooth functioning of each program element. These services will include the management of budget and personnel, and overseeing of communications, publication, and IT facilities. The goal of this facet of the Core will be to provide efficient administrative "resources to all P50~prdject and core investigators so that individual investigators' time for administrative matters will be minimized, permitting maximum time for research endeavors. b. Human Subjects The PSO obtains induced sputum, bronchoalveolar lavage and lower airways epithelial cells (Projects II and 2) and excised human lungs so that the Cell Culture Core (Core C) can provide P50 investigators with well-differentiated cell culture models. In addition, mouse models of smoke exposure will also be tested (Projects II and III). The Administrative Core will facilitate Human Rights Protocol and lACUC submission and compliance with all Federal/University guidelines for human research. c. Personnel Dr. Tarran will be the P50 Principal Investigator and the Core Leader. He will be responsible for all scientific and administrative aspects ofthe P50. He has had administrative experience in leadership of NIH multidisciplinary research programs, including his serving as a Project Leader and Co-lnvestigator on a SCCOR on Airway Biology/Pathogenesis of Cystic Fibrosis and COPD (HL0849334) from 2006-2012 and a PPG from 2007-present (HL110873)

行政核心将为（1）提供（1）专业和（2）程序项目的管理功能。 1）专业组件专业组件旨在监视TCORS P50的整体进展，解决问题的问题，效果质量控制以及为将来的研究提供指导。博士。 Tarran和Doerschuk将为核心提供这种支持。他们将每周与项目和核心领导者会议主持会议，以确保项目的平稳，协调的功能并制定新的研究方向。该职能将与咨询委员会的会议协调。咨询委员会的命名和由： 1）医学博士David Peden，医学和微生物学/免疫学教授，UNC医学院环境医学中心，哮喘和肺部生物学中心主任； 2）詹姆斯·斯威伯格（James Swenberg）博士，肯纳（Kenan）杰出的环境科学与工程学教授；毒理学课程的前主任 3）医学博士Richard Boucher，转化研究执行副院长，杰出医学教授，囊性纤维化/肺部研究与治疗中心主任，也是阻塞性肺部疾病的专家。 另外，博士。 Tarran和Doerschuk将主持每月的行政午餐会，旨在监视P50人员和预算事项，并将监视核心，以确保对项目的充分支持。该核心还将与UNC和大学合同和赠款办公室内的不同部门和部门的管理人员进行界面。 2）管理组件 一个。预算和计划支持： 管理组件将提供确保平滑所需的支持服务 每个程序元素的功能。这些服务将包括预算和人员的管理，并监督通讯，出版和IT设施。核心方面的目的是为所有P50和核心调查人员提供有效的行政资源，以便将个人调查人员的行政事务时间最小化，从而为研究努力提供最大的时间。 b。人类主题 PSO获得诱导的痰，支气管肺泡灌洗和下部气道上皮细胞（项目II和2），并切除人肺，以便细胞培养核心（Core C）可以为P50研究者提供分差良好的细胞培养模型。此外，还将测试烟雾暴露的小鼠模型（项目II和III）。行政核心将促进人权方案，并遵守所有联邦/大学人类研究指南。 c。人事塔兰（Tarran）博士将担任P50首席研究员和核心负责人。他将负责P50的所有科学和行政方面。他在NIH多学科研究计划的领导领导方面具有行政经验，包括他在2006-2012的囊性纤维化和COPD（HL0849334）的SCCOR（HL0849334）的SCCOR上担任项目领导者和共同申请者。