University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

• 批准号: 8813360
• 负责人: Claude W Shuttleworth
• 金额: $ 243.9万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813360
• 关键词: Accident and Emergency department; Acute Brain Injuries; Address; Adoption; Animal Model; Area; Award; Basic Science; Brain; Brain Injuries; Cell Nucleus; Clinical; Clinical Investigator; Clinical Research; Cognitive; Communities; Consultations; Core Facility; Development; Disease; Ensure; Equipment; Extramural Activities; Faculty; Family; Fostering; Funding; Future; Goals; Grant; Growth; Health; Home environment; Hospitals; Housing; Individual; Injury; Intensive Care Units; Intervention; Laboratories; Lead; Leadership; Life; Mentors; Methods; Mexican; Motor; Nervous system structure; New Mexico; Occupational Therapy; Outcome; Pathway interactions; Patients; Phase; Physical therapy; Population; Positioning Attribute; Process; Quality of life; Recovery; Recovery of Function; Research; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Stroke; Structure; Survivors; Symptoms; Technical Expertise; Time; Training; Trauma; Traumatic Brain Injury; United States National Institutes of Health; Universities; Work; base; behavioral health; brain circuitry; brain repair; career development; clinical application; cognitive control; cognitive function; cohort; collaborative environment; community living; cost; cost effective; disability; effective intervention; effective therapy; efficacy testing; experience; health disparity; human subject; improved; mortality; patient advocacy group; personalized intervention; pre-clinical; prevent; programs; public health relevance; repaired; research and development; therapy design/development; therapy development; trauma centers

 DESCRIPTION (provided by applicant): Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and which are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor function, as well as methods that can track individual recovery paths to begin to personalize intervention for the range of symptoms the follow brain injury. Especially critical are approaches that can be applied in the months and years after the injury, as patients are attempting to reintegrate into normal daily life. The Cente for Brain Recovery and Repair will develop an interdisciplinary community of investigators focused on addressing this issue. The Center will bring together a critical mass of investigators from different departments and programs, and provide them with centralized facilities and resources needed to work together on interventions that promote cellular repair of damaged brain, and promote recovery of function. Established investigators from within UNM, together with key external scientific consultants and leadership from community brain injury programs will provide a nucleus of intellectual and technical expertise, and contribute to the development of a cohort of the most promising junior faculty in this field. The Center will focus on moving laboratory discoveries about brain repair mechanisms into clinical application, and is therefore structured to promote extensive interaction between preclinical and clinical investigators. Key resources that are currently lacking will be established, including core facilities with cutting ede facilities for clinical and preclinical interventions and assessments. Investigators will be also b provided with access to other existing facilities and training that can improve their studies and career development. Achieving these aims is expected to lead to development of extramural funding of multiple new programs, including first R01s for junior faculty, and new collaborative awards to teams of established investigators in the Center. These will include future program grants from other NIH centers which, together with strong institutional support, will maintain growth of the Center beyond the period of the current award. Significantly enhanced research capabilities will also be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

 描述（由适用提供）：中风和创伤等脑损伤的幸存者通常会忍受终身疾病，这些疾病跨越了各种各样的缺陷，并且与巨大的个人和社会成本有关。迫切需要开发有效的干预措施，以改善认知和运动功能，以及可以跟踪单个恢复路径以开始在以下脑损伤的症状范围内个性化干预措施的方法。特别是在受伤后几个月和几年中可以应用的方法，因为患者正试图重新融入正常的日常生活。大脑恢复和维修的百分之;将建立一个跨学科的调查人员社区，致力于解决此问题。该中心将汇集来自不同部门和计划的大量调查人员，并为他们提供用于促进损坏大脑细胞修复的干预措施所需的集中式设施和资源，并促进功能恢复。来自UNS内部的既定研究人员与关键的外部科学顾问以及社区脑损伤计划的领导力将提供智力和技术专长的核心，并为发展该领域最有前途的初级教师的共同发展做出贡献。该中心将集中于移动实验室有关脑修复机制的发现，并因此结构促进临床前和临床研究者之间的广泛相互作用。目前缺乏的关键资源将建立，包括核心设施，包括用于临床和临床前干预措施和评估的EDE设施。还将为调查人员提供其他现有设施和培训，以改善他们的研究和职业发展。预计实现这些目标将导致多个新计划的校外资金发展，包括初级教师的第一R01，以及为中心成立的研究人员团队的新合作奖。这些将包括来自其他NIH中心的未来计划赠款，这些计划将在当前裁决期间以后维持该中心的增长。新墨西哥州的大脑和行为健康研究人员的更大选区以及其他思想状态的研究人员也将获得显着增强的研究能力。预计这种结果将产生重要的积极影响，因为它们将极大地加速和采用迫切需要脑损伤后果的思想社区中所需的干预措施。