University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

基本信息

批准号：
8813360
负责人：
Claude W Shuttleworth
金额：
$ 243.9万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8813360
关键词：
Accident and Emergency department Acute Brain Injuries Address Adoption Animal Model Area Award Basic Science Brain Brain Injuries Cell Nucleus Clinical Clinical Investigator Clinical Research Cognitive Communities Consultations Core Facility Development Disease Ensure Equipment Extramural Activities Faculty Family Fostering Funding Future Goals Grant Growth Health Home environment Hospitals Housing Individual Injury Intensive Care Units Intervention Laboratories Lead Leadership Life Mentors Methods Mexican Motor Nervous system structure New Mexico Occupational Therapy Outcome Pathway interactions Patients Phase Physical therapy Population Positioning Attribute Process Quality of life Recovery Recovery of Function Research Research Infrastructure Research Personnel Resource Sharing Resources Stroke Structure Survivors Symptoms Technical Expertise Time Training Trauma Traumatic Brain Injury United States National Institutes of Health Universities Work base behavioral health brain circuitry brain repair career development clinical application cognitive control cognitive function cohort collaborative environment community living cost cost effective disability effective intervention effective therapy efficacy testing experience health disparity human subject improved mortality patient advocacy group personalized intervention pre-clinical prevent programs public health relevance repaired research and development therapy design/development therapy development trauma centers

项目摘要

DESCRIPTION (provided by applicant): Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and which are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor function, as well as methods that can track individual recovery paths to begin to personalize intervention for the range of symptoms the follow brain injury. Especially critical are approaches that can be applied in the months and years after the injury, as patients are attempting to reintegrate into normal daily life. The Cente for Brain Recovery and Repair will develop an interdisciplinary community of investigators focused on addressing this issue. The Center will bring together a critical mass of investigators from different departments and programs, and provide them with centralized facilities and resources needed to work together on interventions that promote cellular repair of damaged brain, and promote recovery of function. Established investigators from within UNM, together with key external scientific consultants and leadership from community brain injury programs will provide a nucleus of intellectual and technical expertise, and contribute to the development of a cohort of the most promising junior faculty in this field. The Center will focus on moving laboratory discoveries about brain repair mechanisms into clinical application, and is therefore structured to promote extensive interaction between preclinical and clinical investigators. Key resources that are currently lacking will be established, including core facilities with cutting ede facilities for clinical and preclinical interventions and assessments. Investigators will be also b provided with access to other existing facilities and training that can improve their studies and career development. Achieving these aims is expected to lead to development of extramural funding of multiple new programs, including first R01s for junior faculty, and new collaborative awards to teams of established investigators in the Center. These will include future program grants from other NIH centers which, together with strong institutional support, will maintain growth of the Center beyond the period of the current award. Significantly enhanced research capabilities will also be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

描述（由申请人提供）：中风和创伤等脑损伤的幸存者往往会遭受终生残疾，这些残疾涉及一系列缺陷，并与巨大的个人和社会成本相关。迫切需要制定有效的干预措施可以改善认知和运动功能，以及可以跟踪个人恢复路径的方法，以便开始针对脑损伤后的一系列症状进行个性化干预，尤其重要的是可以在受伤后数月和数年中应用的方法，例如患者正在尝试重新融入社会大脑恢复和修复中心将建立一个跨学科的研究人员社区，重点解决这一问题，该中心将汇集来自不同部门和项目的大量研究人员，并为他们提供所需的集中设施和资源。共同致力于促进受损大脑细胞修复和促进功能恢复的干预措施，新墨西哥大学内部的资深研究人员与主要的外部科学顾问和社区脑损伤项目的领导者一起，将提供知识和技术专业知识的核心，并做出贡献。培养一批最有前途的初级教师该中心将专注于将有关脑修复机制的实验室发现转化为临床应用，因此将建立目前缺乏的关键资源，包括具有切割功能的核心设施。还将为研究人员提供使用其他现有设施和培训的机会，以改善他们的学习和职业发展，预计将导致多个新项目的外部资助，包括第一个项目。初级教师的 R01 以及向该中心现有研究人员团队提供的新合作奖项，这些将包括来自其他 NIH 中心的未来项目资助，再加上强大的机构支持，将在当前奖项期限之后保持该中心的发展。新墨西哥州更多的大脑和行为健康研究人员以及其他 IDeA 州的研究人员也将获得显着增强的研究能力，预计这些结果将产生重要的积极影响，因为它们将大大加速药物的发现和采用。迫切需要的干预措施对于 IDeA 社区中的大量遭受脑损伤毁灭性后果的人来说。