University of New Mexico (UNM) Center for Brain Recovery and Repair

新墨西哥大学 (UNM) 脑恢复和修复中心

• 批准号: 10400522
• 负责人: Claude W Shuttleworth
• 金额: $ 21.69万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10400522
• 关键词: Acute Brain Injuries; Address; Adoption; Animal Experimentation; Basic Science; Behavior; Brain; Brain Injuries; Caring; Cell Nucleus; Centers of Research Excellence; Clinical; Clinical Investigator; Cognitive; Collaborations; Communities; Complement; Core Facility; Development; Electrophysiology (science); Ensure; Evolution; Exposure to; Extramural Activities; Faculty; Family; Fertilization; Funding; Goals; Grant; Home; Hospitals; Image; Individual; Inpatients; Institution; Intensive Care Units; Interdisciplinary Study; Intervention; Laboratories; Leadership; Life; Mentors; Methods; Mexican; Motor; Neurons; New Mexico; Outcome; Outpatients; Patients; Phase; Physiology; Positioning Attribute; Quality of life; Recovery; Recovery of Function; Research; Research Personnel; Resource Sharing; Resources; Rodent; Rodent Model; Services; Severities; Stroke; Structure; Students; Survivors; Time; Training; Trauma; Traumatic Brain Injury; Traumatic injury; Universities; Work; base; behavioral health; brain health; brain research; career; clinical application; cognitive control; cognitive testing; cohort; community living; cost; data streams; disability; effective intervention; effective therapy; equipment acquisition; faculty mentor; improved; injured; innovation; interdisciplinary collaboration; mortality; multimodal data; neurophysiology; novel; personalized approach; pre-clinical; prevent; programs; repaired; senior faculty; societal costs; success; symposium; tenure track

SUMMARY Survivors of brain injuries such as stroke and trauma often endure life-long disabilities, which span a spectrum of deficits and are associated with enormous individual and societal costs. There is an urgent need to develop effective interventions that can improve cognitive and motor outcomes, especially individualized approaches that target specific disruptions of brain physiology or circuits. The Center for Brain Recovery and Repair was established in Phase I as an interdisciplinary community of investigators to address these issues. A cohort of junior faculty successfully launched new independent research programs and have remained centrally active within the Center. Together with core leadership and other established investigators from diverse departments and programs across campus, we have established a highly interactive nucleus, working closely together in a physical home in Domenici Hall. Phase II activities build on this progress, by adding additional layers of mentored faculty, projects and resources required to ensure a self-sustaining, high impact Center. The Center will maintain its successful focus on moving laboratory discoveries about brain injury mechanisms into clinical application, and will therefore continue to emphasize a structure that promotes extensive mentoring and interaction between preclinical and clinical investigators. The physical home in Domenici Hall will be enhanced, to strengthen state-of-the-art facilities for both rodent studies and clinical interventions and assessment. Recordings from brain-injured patients in the neuro intensive care unit will also be studied in our Domenici Hall core facilities in Phase II, to address novel, actionable mechanisms earlier in the progression of brain injury. Innovative combinations of electrophysiology, imaging and cognitive assessment will be led by both the clinical and preclinical cores, with extensive cross-fertilization of ideas and approaches. An exciting set of projects using these cores will be led by junior faculty from different departments, addressing different severities and consequences of traumatic brain injury. An expanded pilot program, together with new partnerships and tenure-track hires will further increase the critical mass of investigators in the Center, supporting fiscal sustainability and increasing competitiveness for center-level support with additional extramural grants. The Center will leverage existing facilities and trainings at UNM, and expand valuable collaborations with regional IDeA programs for pipeline development and resource sharing. The significantly enhanced research capabilities will thus be available for a larger constituency of brain and behavioral health investigators in New Mexico, and investigators in other IDeA states. Such outcomes are expected to have an important positive impact, as they will greatly accelerate the discovery and adoption of interventions that are urgently needed for large numbers of individuals in IDeA communities living with the devastating consequences of brain injury.

概括 脑部受伤（例如中风和创伤）的幸存者经常忍受终身残疾，而终身残疾 缺陷范围，与巨大的个人和社会成本有关。有紧急 需要制定有效的干预措施，以改善认知和运动结果，尤其是 针对大脑生理或电路特定破坏的个性化方法。中心 大脑恢复和维修是在第一阶段建立的，作为研究人员的跨学科社区 解决这些问题。一批初级教师成功启动了新的独立研究计划 并保持中心位于中心。与核心领导和其他建立 来自校园各个部门和计划的调查人员，我们建立了一个高度的 互动核，在多梅尼奇大厅的一个物理住宅中紧密合作。第二阶段活动建设 在这一进展方面，通过添加其他指导教师，所需的项目和资源来确保 一个自我维持的高影响力中心。该中心将成功地关注移动实验室 有关脑损伤机制进入临床应用的发现，因此将继续强调 一种促进临床前研究者和临床研究人员之间广泛的指导和相互作用的结构。 Domenici Hall的物理住宅将得到增强，以增强两种啮齿动物的最新设施 研究，临床干预和评估。神经脑损伤患者的记录 重症监护室还将在我们的II阶段的Domenici Hall核心设施中进行研究，以解决小说， 早期在脑损伤进展中采用可行的机制。创新组合 电生理学，成像和认知评估将由临床和临床前核心， 通过广泛的思想和方法交叉侵占。使用这些核心的一组令人兴奋的项目将 由来自不同部门的初级教师领导，解决了不同的严重性和后果 创伤性脑损伤。扩大的试点计划，以及新的合作伙伴和终身培训员工 将进一步增加中心调查人员的关键质量，以支持财政的可持续性和 通过额外的壁外补助，提高了中心支持的竞争力。中心将 利用UNM的现有设施和培训，并扩展有价值的合作与区域思想 管道开发和资源共享计划。显着增强的研究能力 因此，新墨西哥州的大脑和行为健康研究人员的更大选区将提供 其他思想状态的调查人员。预计这些结果将产生重要的积极影响，因为它们 将大大加快迫切需要大量需要的干预措施的发现和采用 在想法社区中承受脑损伤后果的个人。