The effect of developmental HL on cellular properties in the auditory striatum

发育性 HL 对听觉纹状体细胞特性的影响

• 批准号: 9105765
• 负责人: Todd M. Mowery
• 金额: $ 15.85万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9105765
• 关键词: Acoustics; Adult; Age; Animal Model; Animals; Auditory; Auditory area; Behavioral; Brain; Brain region; Cells; Child; Childhood; Control Animal; Corpus striatum structure; Development; Ear; Earplug; External auditory canal; Functional disorder; Health; Impaired cognition; Impairment; Language Development; Lead; Learning; Literature; Measures; Membrane; Neurocognitive; Neurons; Noise; Otitis Media; Perception; Physiology; Play; Preparation; Property; Role; Sensory; Slice; Stimulus; Structure; Synapses; Synaptic Membranes; Synaptic plasticity; System; Training; Whole-Cell Recordings; base; behavior measurement; behavioral response; classical conditioning; cognitive process; critical period; deprivation; experience; hearing impairment; language impairment; postnatal; postsynaptic; research study; response; vocal learning

 DESCRIPTION (provided by applicant): Developmental hearing loss is associated with perceptual deficits and delayed language acquisition. Although perceptual sensory deficits are of primary importance, an emerging literature suggests that developmental HL also has an impact on cognitive processes. If so, then brain structures connected to auditory cortex may be altered by a period of deprivation. One brain region implicated in vocal learning, auditory related behavioral deficits, and language impairments is the striatum. Moreover, the projections between the auditory cortex and regions of the striatum receiving auditory inputs can drive behavioral responses. Given the fundamental role that the striatum plays during learning, developmental hearing loss may play a causative role in behavioral deficits. The core hypothesis of this proposal is that cellular properties in the striatum are persistently altered following developmental hearing loss that lead to behavioral deficits. Aim 1 will investigate whether developmental hearing loss induces cellular deficits in the striatum. Aim 2 will determine whether changes to cellular properties in the striatum are correlated with behavioral deficits. Together, this proposal will reveal whether cellular properties in the auditory-recipient striatum are vulnerable to transient HL during development, and offer an animal model on auditory-based learning deficits as seen in children with Otitis Media.

 描述（由申请人提供）：发育性听力损失与知觉缺陷和语言习得延迟有关，尽管知觉感觉缺陷至关重要，但一项新兴文献表明，发育性听力损失也会对认知过程产生影响。与听觉皮层相关的大脑区域可能是一段时间的剥夺，该区域与听觉相关的发声学习有关。 此外，听觉皮层和接收听觉输入的纹状体区域之间的投射可以驱动行为反应，考虑到纹状体在学习过程中发挥的基本作用，发育性听力损失可能起着致病作用。该提案的核心假设是，纹状体中的细胞特性持续改变导致行为缺陷的发育性听力损失。目标 1 将研究发育性听力损失是否会诱发细胞。目标 2 将确定纹状体细胞特性的行为变化是否与听觉接收者的细胞特性相关。 纹状体在发育过程中很容易受到暂时性 HL 的影响，并且提供了一种动物模型，仅在患有中耳炎的儿童中观察到基于听觉的学习缺陷。