High-Density Hermetic Packaging for Next-Generation Neural Prostheses

用于下一代神经假体的高密度密封包装

• 批准号: 8003656
• 负责人: Douglas B. Shire
• 金额: --
• 依托单位: VA BOSTON HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-10-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8003656
• 关键词: Activities of Daily Living; Affect; Age; Age related macular degeneration; Aging; American; Animal Model; Area; Belief; Blindness; Boston; Brain; Bypass; Ceramics; Chronic; Cochlear Implants; Collaborations; Commit; Complex; Custom; Degenerative Disorder; Development; Devices; Electric Stimulation; Electrodes; Eye; Funding; Future; Generations; Grant; Hearing; Hearing Impaired Persons; Human; Image; Implant; In Vitro; Inherited; Institutes; Knowledge; Laboratories; Lead; Learning; Legal Blindness; Macular degeneration; Massachusetts; Medicine; Methods; Microfabrication; Miniature Swine; Mission; Movement; Neurostimulation procedures of spinal cord tissue; Ocular Prosthesis; Operative Surgical Procedures; Optic Nerve; Partner in relationship; Patient Care; Patients; Photoreceptors; Population; Prosthesis; Psychophysiology; Publishing; Rehabilitation therapy; Research; Retina; Retinal; Retinal Diseases; Retinitis Pigmentosa; Structure; Sum; Technology; Testing; Time; Tissues; Titania; Titanium; Translating; Vendor; Vertebrate Photoreceptors; Veterans; Vision; Visual; Visual Acuity; Visual Fields; Visual impairment; Wireless Technology; Work; abstracting; biomaterial compatibility; blind; clinically relevant; cost; density; design; disability; falls; implantation; improved; innovation; medical schools; miniaturize; neural prosthesis; neural stimulation; next generation; patient population; pre-clinical; relating to nervous system; research study; restoration; retinal neuron; retinal prosthesis; social; success; technology development; visual information

DESCRIPTION (provided by applicant): Project Summary/Abstract The aim of this proposal is to develop a new generation of miniaturized implantable micro-stimulators suitable for chronic implantation in a patient's eye to treat degenerative diseases of the retina. In this study, we will use polyimide electrode array structures coated with inorganic materials to provide a long-lasting implant-tissue interface. Custom packaging and assembly methods for the prostheses will also be developed. The tasks to be accomplished under this proposal include the microfabrication of multi-layered electrode array structures in polyimide for mating with our micro-neurostimulator designs. We will also evaluate the biocompatibility and biostability of these structures, which will be done in part at the CIVR through both in vitro soak-testing experiments and through survival surgeries in Yucatan mini- pig animal models with active and passive devices. Together with our vendors, we will fabricate new generations of high-density ceramic feedthroughs and incorporate these into state-of-the- art 200-channel hermetic titanium packages for our retinal microstimulators that will lead to clinically relevant visual prosthetics. The relationship between the proposed effort and the ongoing patient care mission of the VA is that these improvements are expected to open up new rehabilitative possibilities through more specific, targeted neural stimulation than has previously been possible- especially for the restoration of truly useful vision to blind patients, but also in other areas of medicine such as deep brain or spinal cord stimulation. In sum, it is our hope that the blind population we serve will ultimately benefit from the improved visual acuity that will arise from our ability to create complex, highly biostable retinal neurostimulators; additionally, the channel capacity and efficacy of future wireless implantable prostheses of all types is expected to be improved. PUBLIC HEALTH RELEVANCE: Project Narrative As the veteran population ages in the years to come, the loss of the ability to perform the activities of daily living resulting from vision loss due, for example, to age- related macular degeneration (AMD) will occur with great social costs. Action must be taken soon to develop a viable visual prosthesis that can restore truly useful vision to these patients; AMD is the leading cause of blindness in the US. The proposed effort is aimed at technology development that will make this possible. According to the VA's own estimates, the number of veterans with significant visual impairment will reach 430,000 by the year 2011. There exists no current treatment that effectively restores lost vision in the majority of AMD patients, and the urgency of developing rehabilitative means for the growing patient population cannot be overstated.

描述（由申请人提供）： 项目摘要/摘要本提案的目的是开发新一代微型植入式微刺激器，适合长期植入患者眼睛以治疗视网膜退行性疾病。在这项研究中，我们将使用涂有无机材料的聚酰亚胺电极阵列结构来提供持久的植入物-组织界面。还将开发假肢的定制包装和组装方法。该提案要完成的任务包括聚酰亚胺多层电极阵列结构的微加工，以与我们的微神经刺激器设计相匹配。我们还将评估这些结构的生物相容性和生物稳定性，这将在 CIVR 中通过体外浸泡测试实验以及通过使用主动和被动装置在尤卡坦半岛小型猪动物模型中进行生存手术来完成。我们将与我们的供应商一起制造新一代高密度陶瓷馈入件，并将其整合到我们的视网膜微刺激器的最先进的 200 通道密封钛封装中，这将导致临床相关的视觉修复术。拟议的努力与 VA 正在进行的患者护理任务之间的关系是，这些改进预计将通过比以前更具体、更有针对性的神经刺激开辟新的康复可能性，特别是对于恢复盲人真正有用的视力患者，还包括其他医学领域，例如深部脑部或脊髓刺激。 总之，我们希望我们所服务的盲人群体最终能够受益于我们创造复杂、高度生物稳定的视网膜神经刺激器的能力所带来的视力的提高；此外，未来所有类型的无线植入假体的信道容量和功效预计将得到提高。 公共卫生相关性： 项目叙述 随着退伍军人人口在未来几年逐渐老龄化，由于视力丧失（例如年龄相关性黄斑变性（AMD））而导致日常生活活动能力丧失，将会带来巨大的社会成本。必须尽快采取行动开发一种可行的视觉假体，使这些患者恢复真正有用的视力； AMD 是美国导致失明的主要原因。拟议的努力旨在开发使这成为可能的技术。根据退伍军人管理局自己的估计，到2011年，患有严重视力障碍的退伍军人人数将达到43万人。目前还没有有效的治疗方法可以使大多数AMD患者恢复视力，因此为日益增长的视力障碍开发康复手段的紧迫性患者人数怎么强调都不为过。