Eating frequency and its influence on satiety and biomarkers of health & disease

饮食频率及其对饱腹感和健康生物标志物的影响

基本信息

项目摘要

DESCRIPTION (provided by applicant): This proposal will investigate whether eating frequency influences health. Evidence-based recommendations are lacking for the optimal number of daily eating occasions. This is an important area of research because over the past 40 years Americans' eating habits have changed from three meals a day to a pattern whereby most people now have 6-8 daily eating occasions. Apart from potential increases in total energy intake, frequent eating leaves people in a constant postprandial state. This constant, modestly elevated glycemia disturbs the normal glucose-insulin and counter-regulatory hormone network balance and also disturbs downstream cell signaling pathways. A constant postprandial state may increase systemic inflammation and cause numerous other metabolic disturbances. As a result, eating frequency (EF) may be associated with risk of diet-related chronic diseases such as cardiovascular disease, cancer and diabetes, which are the major causes of morbidity, mortality and health care costs in the U.S. To better understand this phenomena we propose a randomized, cross-over clinical trial to test a low-EF eating pattern (three eating occasions/day) vs. a high-EF eating pattern (six eating occasions/day) in relation to inflammation, an adipokine and appetite. We hypothesize that compared to eating three times/day, eating six times/day will increase biomarkers of systemic inflammation, will decrease a beneficial adipokine and will increase both biomarkers and self-reported measures of appetite. We will test our hypothesis with these specific aims: 1) To test the effects of low vs. high eating frequency on inflammatory biomarkers (fasting high-sensitivity C-reactive protein, Interleukin-6 and tumor necrosis factor-�,) and a beneficial adipokine (adiponectin); 2) To test the effects of low vs. high eating frequency on appetite [daily ratings of perceived appetite and serial ratings during a six-hour appetite testing session] and biomarkers involved in appetite regulation and food intake (leptin, ghrelin, peptide YY, and cholecystokinin). We will enroll n=50 males and females who are normal weight, overweight or obese. Participants will complete two 3-week long isocaloric intervention periods in random order [low EF (three eating occasions/day) and high EF (six eating occasions/day)]. Participants will be free-living and eating their own food using study-provided structured meals plans. Study staff will provide on-going support and instruction to maximize adherence to the protocol. Fasting blood samples will be collected at the beginning and end of each study phase. We will test for the intervention effect by using the GEE modification of linear regression to compare mean biomarker response (intervention effect) for each study phase. On the last day of each intervention period, participants will complete 6-hour appetite testing sessions where two test meals will be provided in the low-EF phase and four test meals will be provided in the high-EF phase. Serial appetite ratings and bloods will be collected to assess perceived appetite and hormones of appetite and satiety. Results from this investigation will be used to form guidelines for eating frequency in the context of an overall healthy diet.
描述(由适用提供):该提案将调查饮食频率是否影响健康。对于最佳日常饮食场合,缺乏基于证据的建议。这是一个重要的研究领域,因为在过去的40年中,美国人的饮食习惯从每天的三餐变成了一种模式,现在大多数人现在每天都有6-8个饮食场合。除了总能量摄入量的潜在增加外,经常进食使人们处于持续的餐后状态。这种常数,适度升高的血糖会干扰正常的葡萄糖胰岛素和反调节激素网络平衡,并干扰下游细胞信号通路。持续的餐后状态可能会增加全身感染并引起许多其他代谢疾病。结果,饮食频率(EF)可能与饮食相关的慢性疾病的风险有关,例如心血管疾病,癌症和糖尿病,这是美国发病率,死亡率和医疗保健成本的主要原因感染,脂肪因子和食欲。我们假设,与每天三次吃三次,每天吃六次会增加系统性炎症的生物标志物,将减少有益的脂肪因子,并会增加生物标志物和自我报告的食欲量度。我们将以这些特定目的检验我们的假设:1)测试低饮食频率对炎症生物标志物(禁食高敏化C-反应蛋白,白介素-6和肿瘤坏死因子)的影响和有益的脂肪因子(脂联素); 2)测试低饮食频率与高饮食频率对食欲的影响[在六个小时的食欲测试期间,感知到的食欲和序列评级的每日评级]以及涉及食欲调节和食物摄入量的生物标志物(瘦素,Ghrelin,Peppery,Peppery YY和Cholecystokinin)。我们将招募正常体重,超重或肥胖的50名男性和女性。参与者将按随机顺序完成两个3周的等级干预期[低EF(三种饮食场合/天)和高EF(六次饮食场合/天)]。参与者将使用研究提供的结构化餐食计划自由生活,并自己吃自己的食物。学习人员将提供持续的支持和指导,以最大程度地遵守协议。在每个研究阶段的开始和结束时,将收集空腹血样。我们将通过使用线性回归的GEE修饰来比较每个研究阶段的平均生物标志物反应(干预效果)来测试干预效果。在每个干预期的最后一天,参与者将完成6小时的食欲测试,其中将在低EF期提供两次测试餐,并在高EF期间提供四顿测试餐。将收集串行食欲和血液,以评估食欲和食欲和饱腹感的恐怖。这项投资的结果将用于制定整体健康饮食的饮食频率指南。

项目成果

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Marian L Neuhouser其他文献

Marian L Neuhouser的其他文献

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{{ truncateString('Marian L Neuhouser', 18)}}的其他基金

Physiological changes underlying the weight loss plateau in humans
人类减肥平台期的生理变化
  • 批准号:
    10734323
  • 财政年份:
    2023
  • 资助金额:
    $ 45.36万
  • 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
  • 批准号:
    10191413
  • 财政年份:
    2021
  • 资助金额:
    $ 45.36万
  • 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
  • 批准号:
    10407996
  • 财政年份:
    2021
  • 资助金额:
    $ 45.36万
  • 项目类别:
Red and Processed Meat Effects on the Metabolome and Microbiome
红肉和加工肉对代谢组和微生物组的影响
  • 批准号:
    10596229
  • 财政年份:
    2021
  • 资助金额:
    $ 45.36万
  • 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
  • 批准号:
    8798420
  • 财政年份:
    2014
  • 资助金额:
    $ 45.36万
  • 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
  • 批准号:
    9102198
  • 财政年份:
    2014
  • 资助金额:
    $ 45.36万
  • 项目类别:
Eating frequency and its influence on satiety and biomarkers of health & disease
饮食频率及其对饱腹感和健康生物标志物的影响
  • 批准号:
    9314567
  • 财政年份:
    2014
  • 资助金额:
    $ 45.36万
  • 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
  • 批准号:
    8601154
  • 财政年份:
    2013
  • 资助金额:
    $ 45.36万
  • 项目类别:
Infrastructure Support and Pilot Tissue Collection for the CARET Biorepository
CARET 生物样本库的基础设施支持和试点组织采集
  • 批准号:
    10374863
  • 财政年份:
    2013
  • 资助金额:
    $ 45.36万
  • 项目类别:
Interaction of Vitamin D & Vitamin A with Lung Cancer Risk in Non-Smoking Females
维生素 D 的相互作用
  • 批准号:
    8443600
  • 财政年份:
    2013
  • 资助金额:
    $ 45.36万
  • 项目类别:

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