Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 8550586
• 负责人: Joshua I Goldhaber
• 金额: $ 19.58万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550586
• 关键词: Heart Diseases; Research; Training

DESCRIPTION (provided by applicant): The Cedars-Sinai Heart Institute (CSHI) is applying for a new Institutional Training Grant for its Advanced Heart Disease Research Training Program. The objective of the proposed Training Program is to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years) in order to provide them with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all of our trainees, be they PhDs, MDs or MD/PhDs, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators wih the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of- the-art investigations in the laboratory. Areas of research focus at the CSHI include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, and Genetics. The Training Program takes advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI was established at CSMC in 2007 and has grown rapidly. It is now houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, Medical Genetics Institute, as well as the UCLA Department of Physiology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the CSMC Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence. We will actively recruit outstanding candidates with diverse and underrepresented backgrounds to fill the six positions (three the first year) in this training program.

描述（由申请人提供）：雪松-西奈心脏研究所 (CSHI) 正在为其高级心脏病研究培训计划申请新的机构培训补助金。拟议培训计划的目标是为 6 名博士后研究员（每年 3 人 x 2 年）提供基础生物医学和转化研究方面出色的团队指导培训，以便为他们提供必要的技能，以在以下领域发展独立和富有成效的学术职业：心血管科学。我们力求确保所有学员，无论是博士、医学博士还是医学博士/博士，都能深入了解支持心血管医学临床相关问题的基础科学，并对严格的研究设计、适当的研究有全面的了解。基础和临床研究的方法论和专家技术执行。这不仅为临床研究人员提供了正确检验在基础科学层面产生的假设所需的技能，而且还让基础科学家了解疾病的临床方面，以刺激实验室中临床相关的最先进的研究。 CSHI 的研究重点领域包括心脏生物学、心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、心血管成像、妇女健康和遗传学。该培训计划利用了雪松西奈医疗中心 (CSMC) 的独特优势，该中心是密西西比河以西最大的私立教学医院，长期致力于转化研究和服务当地社区。 CSHI于2007年在华润上华成立，并发展迅速。它现在拥有世界上最大的成人心脏移植项目，进行了 NIH 资助的首次心脏干细胞疗法人体试验，并吸引了许多 NIH 资助的基础和转化研究人员。其中一些在 CSMC 的其他单位担任联合职务，包括再生医学研究所、生物医学成像研究所、医学遗传学研究所以及加州大学洛杉矶分校生理学系。学员将获得重点调查领域的深入研究经验，并辅以正式课程，包括基础和临床研讨会、拨款和手稿写作指导、公开演讲、生物统计学和伦理学。 CSMC 生物医学科学系、CSMC 临床学者计划和 NIH CTSA 支持的多校区转化科学研究中心 (CTSI，包括 CSMC、加州大学洛杉矶分校、Harbor-UCLA 和查尔斯·德鲁大学) 提供多项课程。 CTSI 为我们的学员提供了获得项目种子资金的特权、临床研究设计的附加课程以及用于进行从实验室到临床到社区的整个研究范围的工具。总之，我们设计了一个计划，在支持转化研究和临床卓越的环境中提供心血管科学关键领域的深入培训。我们将积极招募具有多元化和代表性不足的背景的优秀候选人来填补本次培训计划的六个职位（第一年三个）。