Training in Advanced Heart Disease Research

高级心脏病研究培训

• 批准号: 10000201
• 负责人: Joshua I Goldhaber
• 金额: $ 49.8万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10000201
• 关键词: Heart Diseases; Research; Training

The Cedars-Sinai Heart Institute (CSHI) is applying for the first competitive renewal of its Advanced Heart Disease Research Training Program. The objective of this Institutional Training Program is to build on our initial success (66% success rate for K awards in our first graduating class) to provide outstanding team-mentored training in basic biomedical and translational research to six postdoctoral fellows (3 per year x 2 years). The goal is to provide postdoctoral fellows with the necessary skills to develop independent and productive academic careers in cardiovascular science. We seek to ensure that all our trainees, be they PhDs, MDs, MD/PhDs or equivalent, develop an in-depth knowledge of the basic science underpinning clinically relevant problems in cardiovascular medicine, as well as a comprehensive understanding of rigorous study design, appropriate methodology and expert technical execution of basic and clinical studies. This not only provides clinical investigators with the skills they need to properly test hypotheses generated at the basic science level, but also informs basic scientists about the clinical aspects of disease in order to stimulate clinically relevant state-of-the- art investigations in the laboratory. Our training program's areas of research focus include Cardiac Biology, Arrhythmias, Vascular Biology and Atherosclerosis, Regenerative Medicine, Transplant Immunology, Cardiovascular Imaging, Women's Health, Community Health, Implementation Science, Precision Medicine and Genetics. The Training Program takes full advantage of the unique strengths of Cedars-Sinai Medical Center (CSMC), the largest private teaching hospital west of the Mississippi, which has a longstanding commitment to translational research and to serving the local community. The CSHI houses the largest adult heart transplant program in the world, performed an NIH-funded first-in-human trial of cardiac-derived stem cell therapy, and has attracted many NIH-funded basic and translational investigators. Some of these share joint appointments in other CSMC units, which include the Regenerative Medicine Institute, Biomedical Imaging Research Institute, and the Departments of Biomedical Sciences, Medicine, and Pathology. Trainees receive an intensive research experience in a focused area of investigation, augmented by a formal curriculum that includes both basic and clinical seminars, instruction in grant and manuscript writing, public speaking, biostatistics and ethics. Several courses are provided by the Department of Biomedical Sciences, the CSMC Clinical Scholars Program, and a multi-campus NIH CTSA-supported Center for Translational Science Institute (CTSI, includes CSMC, UCLA, Harbor-UCLA, and Charles Drew University). The CTSI provides our trainees with privileged access to project seed funds, additional courses in clinical research design, and tools for conducting the entire range of studies from bench to bedside to community. In summary, we have designed a program that provides in-depth training in critical areas of cardiovascular science within an environment that champions translational research and clinical excellence.

雪松西奈心脏研究所 (CSHI) 正在申请其高级心脏的首次竞争性更新 疾病研究培训计划。该机构培训计划的目标是在我们最初的基础上 成功（我们第一届毕业班的 K 奖成功率为 66%），提供出色的团队指导 为 6 名博士后研究员提供基础生物医学和转化研究方面的培训（每年 3 名，× 2 年）。目标 是为博士后研究员提供必要的技能来发展独立和富有成效的学术 心血管科学领域的职业。我们力求确保所有学员，无论是博士、医学博士、医学博士/博士还是 同等水平，深入了解支持临床相关问题的基础科学 心血管医学，以及对严格研究设计的全面理解，适当 基础和临床研究的方法论和专家技术执行。这不仅提供了临床 研究人员拥有正确检验基础科学水平上产生的假设所需的技能，而且 向基础科学家提供有关疾病临床方面的信息，以激发临床相关的最新进展 实验室里的艺术研究。我们的培训计划的研究重点领域包括心脏生物学、 心律失常、血管生物学和动脉粥样硬化、再生医学、移植免疫学、 心血管影像、妇女健康、社区健康、实施科学、精准医学和 遗传学。该培训计划充分利用了 Cedars-Sinai 医疗中心的独特优势 (CSMC) 是密西西比河以西最大的私立教学医院，长期致力于 转化研究并服务当地社区。 CSHI 拥有最大的成人心脏移植手术 计划在世界范围内进行，进行了美国国立卫生研究院 (NIH) 资助的首次人体心脏来源干细胞治疗试验，并已 吸引了许多 NIH 资助的基础和转化研究人员。其中一些在其他机构中共同任职 华润医疗旗下单位包括再生医学研究所、生物医学影像研究所、 生物医学科学、医学和病理学系。学员接受深入研究 在重点调查领域的经验，并通过包括基础和 临床研讨会、拨款和手稿写作指导、公开演讲、生物统计学和伦理学。一些 课程由生物医学科学系、华润医疗临床学者计划和 NIH CTSA 支持的多校区转化科学研究中心 (CTSI，包括 CSMC、加州大学洛杉矶分校、 港口-加州大学洛杉矶分校和查尔斯德鲁大学）。 CTSI 为我们的学员提供了参与项目的特权 种子基金、临床研究设计的附加课程以及进行整个研究范围的工具 从工作台到床边再到社区。综上所述，我们设计了一个提供深度培训的方案 在支持转化研究的环境中，在心血管科学的关键领域 临床卓越。