FASEB SRC on Ion Channel Regulation

FASEB SRC 关于离子通道调节

• 批准号: 8907639
• 负责人: AMY LEE
• 金额: $ 2万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8907639
• 关键词: Accounting; Address; Affect; Area; Arrhythmia; Ataxia; Basic Science; Biology; Biophysics; Brain; Caring; Carrier Proteins; Cell membrane; Chemical Engineering; Collaborations; Conflict (Psychology); Cystic Fibrosis; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Drug Targeting; Educational workshop; Electrophysiology (science); Environment; Epilepsy; Family; Fees; Financial Support; Fostering; Functional disorder; Funding; Future; General Population; Genes; Goals; Grant; Health; Hearing; Heart; Home environment; Human; Impairment; Inborn Genetic Diseases; Institution; Ion Channel; Ions; Iowa; Lilium; Malignant Neoplasms; Mass Spectrum Analysis; Mental disorders; Mentors; Migraine; Molecular; Montana; Movement; Mus; Mutation; Myopathy; Ohio; Pain; Paralysed; Pathogenesis; Pathway interactions; Phenotype; Physiological; Physiology; Population; Proteome; Rare Diseases; Recruitment Activity; Regulation; Research; Research Personnel; Resources; Science; Scientist; Seeds; Signal Transduction; Solutions; Staging; Structure; Time; Tissues; Training; Translations; Travel; Underrepresented Minority; United States National Institutes of Health; Universities; Vision; Woman; Work; abstracting; aqueous; base; career; career development; chronic pain; clinically relevant; college; design; disease-causing mutation; global health; high throughput screening; improved; in vivo; lectures; meetings; member; next generation; novel; novel therapeutics; painful neuropathy; posters; prevent; programs; public health relevance; social; structural biology; sudden cardiac death; symposium; synergism

 DESCRIPTION (provided by applicant): This is an application for partial support of the 7th biennial FASEB Science Research Conference on Ion Channel Regulation. The objective of this conference is to stimulate discourse, seed new ideas, and stimulate collaboration in ways that will accelerate new discoveries about ion channels at the basic and translational levels. Accounting for ~1.5% of human genes, ion channels are subject to numerous disease-causing mutations. There are more than 55 inherited disorders that are attributed to mutations in genes encoding ion channels. These "channelopathies" affect the brain (e.g., epilepsy, migraine, ataxia), the heart (e.g., cardiac arrhythmia), and other tissues (e.g., hearing and vision impairment, cystic fibrosis, muscle disease). Not surprisingly, ion channels are major drug targets in the treatment of cardiac arrhythmia, epilepsy, and neuropathic pain. Dysregulation of ion channels is strongly associated with cancer and mental illness, both of which are profound global health concerns. Thus, the topic of our conference is both timely and highly relevant for a broad population of scientists, clinicians, and the general public. The Co-chairs of the 2015 conference will be Dr. Amy Lee (University of Iowa) and Dr. Peter Mohler (Ohio State University), both recognized leaders in ion channel biology with an emphasis on channel regulation. The Program consists of nine scientific sessions, 1 keynote address, and a panel session titled "Challenges and Opportunities for Women in Science". Most sessions were organized around general themes rather than ion channel subtype, to foster crosstalk between fields typically kept separate in traditional conferences. Several of the planned talks focus upon the molecular and cellular basis of rare diseases (channelopathies). There will be 36 session speakers giving full talks, including 14 women (39% of speakers) and 9 session chairs (5 of whom are women, 55%). Most of the invited speakers have not presented at this conference during the prior two meetings. Of the 36 session speakers, we are planning to include 6 early career stage investigators and 6 members of under- represented minorities in science (17%), numbers that will be bolstered in 8 short talks to be selected from submitted abstracts; we will also work with institutions from historically underfunded states the within the West to encourage their participation, thereby encouraging novel collaborations. The conference venue has appropriate facilities for disabled attendees.

 描述（由应用程序提供）：这是对第七届双年展FaseB科学研究会议的部分支持的应用程序。这次会议的目的是刺激话语，播种新思想，并以基本和翻译层面上有关离子渠道的新发现的方式刺激协作。占人类基因的约1.5％，离子通道受到许多引起疾病的突变。有55种以上的遗传疾病归因于编码离子通道的基因中的突变。这些“通道病”会影响大脑（例如癫痫，偏头痛，共济失调），心脏（例如心律失常）和其他组织（例如，听力和视力障碍，囊性纤维化，肌肉疾病）。毫不奇怪，离子通道是治疗心律不齐，癫痫和神经性疼痛的主要药物靶标。离子通道的失调与癌症和精神疾病密切相关，这两者都引起了全球健康问题。这是我们会议的主题既及时又与广泛的科学家，临床医生和公众高度相关。 2015年会议的联合主席将是爱荷华大学艾米·李（Amy Lee）博士和俄亥俄州立大学彼得·莫勒（Peter Mohler）博士，他们都认可了离子渠道生物学领域的领导者，重点是渠道调节。该计划包括九次科学会议，1个主题演讲，以及一个名为“科学女性的挑战和机会”的小组会议。大多数课程都是围绕一般主题而不是离子通道亚型组织的，以促进通常在传统会议中分开的领域之间的串扰。一些计划的谈判集中在罕见疾病（通道病）的分子和细胞基础上。将有36个会议的演讲者进行全面的演讲，其中包括14名女性（39％的演讲者）和9张会议主持人（其中5名是女性，55％）。大多数受邀的演讲者在上一次会议上没有在本次会议上介绍。在36个会议演讲者中，我们计划包括6名早期职业阶段调查人员和6位科学少数群体的成员（17％），这些数字将在8个简短的演讲中得到支持，以从提交的摘要中选出；我们还将与西方内部资金不足的国家的机构合作，以鼓励他们的参与，从而鼓励新的合作。会议场地为残疾与会者提供适当的设施。