Membrane Protein Folding

膜蛋白折叠

• 批准号: 8529131
• 负责人: JAMES U BOWIE
• 金额: $ 0.5万
• 依托单位: BIOPHYSICAL SOCIETY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8529131
• 关键词: Aging; Alzheimer' s Disease; Applications Grants; Biogenesis; Biological; Biological Process; Biology; Biophysics; Crystallography; Cystic Fibrosis; Development; Disease; Fertilization; Financial Support; Fostering; Funding Applicant; Future; Gene Expression; Goals; Health; Housing; Human; Institutes; International; Kinetics; Korea; Medical; Membrane; Membrane Proteins; Mentors; Metabolism; Molecular Biology; Motion; Mutation; Parkinson Disease; Participant; Pharmaceutical Preparations; Property; Proteins; Research Personnel; Role; Running; Science; Scientist; Signal Pathway; Societies; South Korea; Structure; Techniques; Thermodynamics; Time; Work; design; directed evolution; experimental analysis; forest; high throughput screening; in vivo; interest; meetings; molecular dynamics; next generation; novel therapeutics; posters; protein folding; protein protein interaction; public health relevance; research study; simulation; single molecule; symposium; trend

DESCRIPTION (provided by applicant): Funds are requested to support a Biophysical Society sponsored "Thematic Meeting on Membrane Protein Folding." Because of its central role in biology, protein folding has been a major topic in molecular biology over the last 50 years. Yet work on membrane protein folding has been surprisingly limited. While there are many meetings in protein folding, it is common that membrane proteins are not even included. As a result there remains a major gap in our understanding of these important proteins and their associated misfolding diseases. The goal of the meeting is to foster the development of this still fledgling field by devoting a meeting entirely to the topic. To promote international participation in the field, we will hold the meeting at the Korea Institute for Advanced Study (KIAS) in Seoul, South Korea. Most of the participants will be housed on the forested KIAS campus and we will take meals together in the KIAS cafeteria, which will facilitate interactions. Many conferences are held at KIAS so they have considerable expertise in running meetings and they will also provide generous financial support for this meeting. We will bring together a group of scientists who have both practical and fundamental interest in the problem of membrane protein folding. While the focus is on biophysical aspects of the protein folding problem, we have included a session on misfolding diseases and have included three talks on the involvement of membranes in the aging diseases, Parkinson's and Alzheimer's. We have also incorporated diverse techniques including single molecule experiments, NMR, crystallography, computational prediction and design, molecular dynamics simulations, experimental analysis of the thermodynamics and kinetics of folding, directed evolution for stability, and in vivo folding. This group should make or a lively discussion with participants who will bring many different perspectives to the problem. We are very interested in attracting and supporting the next generation of scientists to this field so we have incorporated a number of talks that will be selected from poster presenters, who are traditionally more junior investigators. We will also facilitate the mentoring of young scientists y adding "topic tables" at lunches where young investigators will be encouraged to sit with senior investigators. In part, through this grant application, we very much hope to provide support for junior scientists to come to the meeting.

描述（由申请人提供）：请求资金支持生物物理学会主办的“膜蛋白折叠专题会议”。由于其在生物学中的核心作用，蛋白质折叠在过去 50 年中一直是分子生物学的一个主要话题。然而，关于膜蛋白折叠的工作却出人意料地有限。虽然蛋白质折叠方面有很多会议，但通常甚至不包括膜蛋白。因此，我们对这些重要蛋白质及其相关错误折叠疾病的理解仍然存在重大差距。会议的目标是通过专门讨论该主题来促进这一新兴领域的发展。为了促进该领域的国际参与，我们将在韩国首尔的韩国高等研究院（KIAS）举行会议。大多数参与者将住在森林茂盛的 KIAS 校园内，我们将在 KIAS 自助餐厅一起用餐，这将促进互动。许多会议都是在 KIAS 举行，因此他们在举办会议方面拥有丰富的专业知识，并且还将为本次会议提供慷慨的财务支持。我们将聚集一群对膜蛋白折叠问题有实际和根本兴趣的科学家。虽然重点是蛋白质折叠问题的生物物理方面，但我们还安排了一场关于错误折叠疾病的会议，并包括三场关于细胞膜与衰老疾病、帕金森病和阿尔茨海默病的关系的演讲。我们还结合了多种技术，包括单分子实验、核磁共振、晶体学、计算预测和设计、分子动力学模拟、折叠热力学和动力学的实验分析、稳定性定向进化和体内折叠。该小组应该与参与者进行热烈的讨论，他们将对问题提出许多不同的观点。我们非常有兴趣吸引和支持下一代科学家进入这一领域，因此我们纳入了许多将从海报演示者中选出的演讲，这些演讲者传统上都是初级研究人员。我们还将促进对年轻科学家的指导，在午餐中添加“主题桌”，鼓励年轻研究人员与高级研究人员坐在一起。在某种程度上，通过这次资助申请，我们非常希望为参加会议的年轻科学家提供支持。