Combined Multi-Pinhole and Fan-Beam Brain SPECT

结合多针孔和扇束脑 SPECT

• 批准号: 9082307
• 负责人: Michael A King
• 金额: $ 35.46万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-18 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9082307
• 关键词: Address; Air; Algorithms; Arizona; Beds; Binding; Biological Models; Brain; Brain imaging; Brain region; Breast; Calibration; Clinic; Clinical; Collimator; Computer software; Corpus striatum structure; Coupled; Data; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Early Diagnosis; Financial compensation; Funding; Gamma Rays; Geometry; Goals; Head; Image; Imagery; Imaging Techniques; Label; Location; Measurement; Measures; Methodology; Monitor; Monte Carlo Method; Morphologic artifacts; Motion; Occipital lobe; Parkinson Disease; Patients; Penetration; Perfusion; Photons; Positron-Emission Tomography; Price; Procedures; Resolution; Rotation; Safety; Sampling; Security; Structure; Substantia nigra structure; System; Testing; Thick; Thyroid Gland; Time; United States National Institutes of Health; Universities; Validation; Weight; Wireless Technology; attenuation; base; bone imaging; cost; density; design; design and construction; detector; imaging agent; improved; innovation; interest; irradiation; nervous system disorder; novel; operation; public health relevance; putamen; reconstruction; response; simulation; single photon emission computed tomography; ultra high resolution; uptake

 DESCRIPTION (provided by applicant): The recent FDA approval of the SPECT imaging agent I-123 labeled DaTscan for diagnosis and monitoring progression of Parkinson's Disease (PD) has open up a new era in SPECT brain imaging. Unlike with perfusion imaging where the entire brain is the volume of interest, with PD the structures of interest are the putamen and caudate (and potentially substantia nigra) which lie in the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding rati (SBR), a parameter of significance in the early diagnosis and differentiation of PD from other disorders with similar clinical presentations. Our hypothesis is that combining a specifically designed multi-pinhole (MPH) collimator on one detector head with a fan-beam collimator on the remaining head of current dual-headed SPECT systems, coupled with iterative reconstruction with modeling system spatial resolution, will result in improved detection and quantification of structures in the interior region of the brain at marginal cost (the price of collimator(s) and reconstruction software). The MPH collimator would be designed to provide enhanced spatial resolution / sensitivity for the interior of the brain. The fan-beam collimator would provide lower resolution but complete sampling of the brain addressing data sufficiency and allowing a volume-of-interest to be defined over the occipital lobe for calculation of SBR's. Clinically this would provide a low-cost system allowing improved visualization and relative quantification of function of structures in the interior region of the brain, potentially as small as the ~4 mm substantia nigra, which cannot currently be achieved by other than expensive, brain dedicated, SPECT systems. This would greatly impact the early detection and differentiation of PD, and possibly other neurological disorders as new SPECT imaging agents are approved. Our approach for further investigating our hypothesis is based on the initial exploration we have conducted under funding provided by NIH R21 EB016391 and is organized into five specific aims. The first specific aim is to complete the optimization of the MPH collimator design through task-based optimization for the tasks of detection using the Channelized Hotelling Observer (CHO) and quantification of striatal function by calculation of the SBR. The second specific aim is to finish development of inclusion of MPH system geometry and response in reconstruction. The third specific aim is to have our colleagues at the Center for Gamma Ray Imaging (CGRI) at the University of Arizona construct the MPH. The fourth specific aim is to install and test the combined fan-beam and MPH system on a SPECT/CT camera using phantoms. Our fifth specific aim is to image five patients with the combined system.

 描述（由申请人提供）： FDA 最近批准标记为 DaTscan 的 SPECT 成像剂 I-123 用于诊断和监测帕金森病 (PD) 的进展，开辟了 SPECT 脑成像的新时代，与灌注成像不同。大脑是感兴趣的体积，对于 PD，感兴趣的结构是位于大脑内部的壳核和尾状核（可能还有黑质），但是枕叶的成像。 PD 还需要计算纹状体结合率 (SBR)，该参数对于早期诊断以及将 PD 与具有类似临床表现的其他疾病区分开来具有重要意义。我们的假设是结合专门设计的多针孔 (MPH)。当前双头 SPECT 系统的一个探测器头上装有一个准直器，另一个探测器头上装有扇形束准直器，再加上建模系统空间分辨率的迭代重建，将改善大脑内部区域结构的检测和量化边际成本（准直器和重建软件的价格） MPH 准直器旨在为大脑内部提供增强的空间分辨率/灵敏度，而扇形束准直器将提供较低的成本。 分辨率，但对大脑进行完整采样，解决数据充分性问题，并允许在枕叶上定义感兴趣的体积以进行 SBR 的计算。在临床上，这将提供一种低成本系统，改进结构中结构功能的可视化和相对量化。大脑内部区域可能小至约 4 毫米的黑质，目前只能通过昂贵的大脑专用 SPECT 系统来实现，这将极大地影响 PD 的早期检测和区分。我们进一步研究我们的假设的方法是基于我们在 NIH R21 EB016391 资助下进行的初步探索，并分为五个具体目标。通过使用通道化霍特林观测器 (CHO) 进行基于任务的检测任务优化来优化 MPH 准直器设计，并通过计算 SBR 来量化纹状体功能。第三个具体目标是让亚利桑那大学伽马射线成像中心 (CGRI) 的同事构建 MPH。第四个具体目标是安装和测试组合风扇。使用模型的 SPECT/CT 相机上的光束和 MPH 系统我们的第五个具体目标是使用组合系统对五名患者进行成像。