Combined Multi-Pinhole and Fan-Beam Brain SPECT

结合多针孔和扇束脑 SPECT

• 批准号: 9082307
• 负责人: Michael A King
• 金额: $ 35.46万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-18 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9082307
• 关键词: Address; Air; Algorithms; Arizona; Beds; Binding; Biological Models; Brain; Brain imaging; Brain region; Breast; Calibration; Clinic; Clinical; Collimator; Computer software; Corpus striatum structure; Coupled; Data; Detection; Development; Diagnosis; Discipline of Nuclear Medicine; Disease; Early Diagnosis; Financial compensation; Funding; Gamma Rays; Geometry; Goals; Head; Image; Imagery; Imaging Techniques; Label; Location; Measurement; Measures; Methodology; Monitor; Monte Carlo Method; Morphologic artifacts; Motion; Occipital lobe; Parkinson Disease; Patients; Penetration; Perfusion; Photons; Positron-Emission Tomography; Price; Procedures; Resolution; Rotation; Safety; Sampling; Security; Structure; Substantia nigra structure; System; Testing; Thick; Thyroid Gland; Time; United States National Institutes of Health; Universities; Validation; Weight; Wireless Technology; attenuation; base; bone imaging; cost; density; design; design and construction; detector; imaging agent; improved; innovation; interest; irradiation; nervous system disorder; novel; operation; public health relevance; putamen; reconstruction; response; simulation; single photon emission computed tomography; ultra high resolution; uptake

 DESCRIPTION (provided by applicant): The recent FDA approval of the SPECT imaging agent I-123 labeled DaTscan for diagnosis and monitoring progression of Parkinson's Disease (PD) has open up a new era in SPECT brain imaging. Unlike with perfusion imaging where the entire brain is the volume of interest, with PD the structures of interest are the putamen and caudate (and potentially substantia nigra) which lie in the interior portion of the brain. However imaging of the occipital lobe is also required with PD for calculation of the striatal binding rati (SBR), a parameter of significance in the early diagnosis and differentiation of PD from other disorders with similar clinical presentations. Our hypothesis is that combining a specifically designed multi-pinhole (MPH) collimator on one detector head with a fan-beam collimator on the remaining head of current dual-headed SPECT systems, coupled with iterative reconstruction with modeling system spatial resolution, will result in improved detection and quantification of structures in the interior region of the brain at marginal cost (the price of collimator(s) and reconstruction software). The MPH collimator would be designed to provide enhanced spatial resolution / sensitivity for the interior of the brain. The fan-beam collimator would provide lower resolution but complete sampling of the brain addressing data sufficiency and allowing a volume-of-interest to be defined over the occipital lobe for calculation of SBR's. Clinically this would provide a low-cost system allowing improved visualization and relative quantification of function of structures in the interior region of the brain, potentially as small as the ~4 mm substantia nigra, which cannot currently be achieved by other than expensive, brain dedicated, SPECT systems. This would greatly impact the early detection and differentiation of PD, and possibly other neurological disorders as new SPECT imaging agents are approved. Our approach for further investigating our hypothesis is based on the initial exploration we have conducted under funding provided by NIH R21 EB016391 and is organized into five specific aims. The first specific aim is to complete the optimization of the MPH collimator design through task-based optimization for the tasks of detection using the Channelized Hotelling Observer (CHO) and quantification of striatal function by calculation of the SBR. The second specific aim is to finish development of inclusion of MPH system geometry and response in reconstruction. The third specific aim is to have our colleagues at the Center for Gamma Ray Imaging (CGRI) at the University of Arizona construct the MPH. The fourth specific aim is to install and test the combined fan-beam and MPH system on a SPECT/CT camera using phantoms. Our fifth specific aim is to image five patients with the combined system.

 描述（由适用提供）：SPECT成像剂I-123标记为DATSCAN的FDA批准，用于诊断和监测帕金森氏病（PD）的进展，已在Spect Brain Imaging中开放了一个新时代。与灌注成像不同的是，整个大脑是感兴趣的体积，PD感兴趣的结构是位于大脑内部部分的壳核和尾状（以及潜在的黑核酸）。但是，PD还需要对枕叶的成像进行计算，以计算纹状体结合RATI（SBR），这是PD早期诊断和分化与其他具有相似临床表现的疾病的显着性和分化的参数。 Our hypothesis is that combining a specifically designed multi-pinhole (MPH) collimator on one detector head with a fan-beam collimator on the remaining head of current dual-headed SPECT systems, coupled with iterative reconstruction with modeling system spatial resolution, will result in improved detection and quantification of structures in the interior region of the brain at marginal cost (the price of collimator(s) and reconstruction software). MPH准直仪的设计旨在为大脑内部提供增强的空间分辨率 /灵敏度。风扇梁直接仪将提供较低的 分辨率但对大脑的完整采样，以解决数据的充分性，并允许在枕叶上定义利益，以计算SBR。从临床上讲，这将提供一个低成本的系统，可以改善大脑内部区域内结构功能的可视化和相对量化，这可能与〜4 mm底底底底，目前无法通过其他昂贵的大脑专用Spect System Systems来实现。这将极大地影响PD的早期检测和区分，并可能随着新的SPECT成像剂的批准，可能会影响其他神经系统疾病。我们的进一步研究假设的方法是基于我们根据NIH R21 EB016391提供的资金进行的最初探索，并将其组织为五个具体目标。第一个具体目的是通过基于任务的优化使用通道化的hotelling观察者（CHO）来完成对检测任务的优化，并通过计算SBR来量化纹状体功能。第二个具体目的是完成重建中MPH系统几何形状和响应的发展。第三个具体的目的是在亚利桑那大学建设MPH的伽马射线成像中心（CGRI）中心。第四个特定目的是使用幻影在SPECT/CT摄像机上安装和测试组合的风扇梁和MPH系统。我们的第五个具体目的是将五名患者与组合系统成像。