COG Biospecimen Bank

COG 生物样本库

• 批准号: 8913447
• 负责人: Julie M Gastier-Foster
• 金额: $ 290.84万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-22 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8913447
• 关键词: Adolescent; Adverse effects; Affect; Basic Science; Biological; Canada; Cancer Patient; Child; Childhood; Childhood Cancer Treatment; Clinical; Clinical Research; Clinical Treatment; Clinical Trials; Clinical Trials Cooperative Group; Collection; Communities; Conduct Clinical Trials; Data; Databases; Diagnosis; Enrollment; Ensure; Fostering; Guidelines; Human; Improve Access; Informatics; Institution; Laboratories; Malignant - descriptor; Malignant Childhood Neoplasm; Malignant Neoplasms; Microscopy; Mission; National Clinical Trials Network; Nucleic Acids; Pathology; Patients; Pediatric Hospitals; Pediatric Oncology; Pediatric Oncology Group; Phase; Play; Procedures; Process; Quality Control; Randomized; Research; Research Institute; Research Personnel; Resources; Role; Services; Solutions; Specimen; Structure; Testing; Translational Research; Treatment outcome; Tumor Bank; United States; Work; anticancer research; base; biobank; cancer therapy; improved; phase II trial; population based; public health relevance; racial and ethnic; satisfaction; success; technological innovation; tool; treatment trial; virtual

 DESCRIPTION (provided by applicant): The Children's Oncology Group (COG) is the pediatric clinical trials group of the National Clinical Trials Network (NCTN). Over 90% of United States and Canadian children and adolescents with cancer are treated at COG institutions with no racial, ethnic or geographic bias to registration, allowing for near-population-based clinical, translational and basic research. COG has established a strong track record of collecting and banking tumor and non-diseased biospecimens from patients enrolled in COG-sponsored clinical trials, most of which include randomized treatment questions. The COG Biospecimen Bank (COG BB), located within the Biopathology Center at Nationwide Children's Hospital, aims to provide high-quality pediatric and adolescent human malignant biospecimens to the research community. Annually, the COG BB receives and banks over 100,000 specimens from approximately 5,500 COG patients from over 225 COG institutions, and distributes approximately 10,000 specimens to approved investigators. The bank also offers services such as nucleic acid isolations, pathology review, virtual microscopy, clinical reference laboratory testing, and informatics initiatives. This proposal supports the collection, processing, and distribution of biospecimens from patient enrolled on COG Phase III and large Phase II trials (approximately 4,000 patients per year). The COG BB seeks to directly promote and support outstanding research in the diagnosis and treatment of pediatric cancer through centralized collection, quality control, storage, and distribution procedures. The COG BB will continue efforts to provide the latest biorepository based technological innovations and best practices, resulting in constant improvements in our operational capabilities, investigator access to biospecimens, investigator satisfaction, and the stewardship of these precious resources. Under proper regulatory guidelines and in association with the COG Statistical and Data Center, the COG BB will support translational aspects of cutting-edge research by ensuring appropriate tracking of biospecimens as well as linkages to existing demographic, clinical, biological, treatment, and outcome data. Finally the COG BB will provide investigators with a comprehensive database solution and dynamic informatics tools that facilitate pediatric cancer research, including the use of the Biospecimen IT Navigator and the NCTN Biospecimen front door services.

 描述（由申请人提供）：儿童肿瘤学组 (COG) 是国家临床试验网络 (NCTN) 的儿科临床试验组，超过 90% 的美国和加拿大癌症儿童和青少年在 COG 机构接受治疗。 COG 已建立了从注册患者收集和储存肿瘤和非疾病生物样本的良好记录。位于全国儿童医院生物病理学中心的 COG 生物样本库 (COG BB) 旨在为研究界提供高质量的儿科和青少年人类恶性生物样本。每年，COG BB 都会接收并储存来自超过 225 个 COG 机构的约 5,500 名 COG 患者的超过 100,000 份样本，并分发约该银行还向批准的研究人员提供 10,000 份样本，并提供核酸分离、病理学审查、虚拟显微镜检查、临床参考实验室测试和信息学计划等服务。该提案支持收集、处理和分发 COG 阶段患者的生物样本。 III 期和大型 II 期试验（每年约 4,000 名患者） COG BB 致力于通过集中收集、质量保证来直接促进和支持儿科癌症诊断和治疗方面的杰出研究。 COG BB 将继续努力提供基于生物样本库的最新技术创新和最佳实践，从而不断提高我们的运营能力、研究者对生物样本的获取、研究者的满意度以及这些宝贵资源的管理。在适当的监管指导下，并与 COG 统计和数据中心合作，COG BB 将通过确保对生物样本的适当跟踪以及与现有人口、临床、生物学、治疗和治疗的联系来支持尖端研究的转化。结果最后，COG BB 将为研究人员提供全面的数据库解决方案和动态信息学工具，以促进儿科癌症研究，包括使用 Biospecimen IT Navigator 和 NCTN Biospecimen 前门服务。