CRCNS: Decision-making in flying insects using multisensory cues

CRCNS：使用多感官线索进行飞行昆虫决策

• 批准号: 8871713
• 负责人: Michael H Dickinson
• 金额: $ 27.82万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8871713
• 关键词: Address; Affect; Air; Algorithm Design; Algorithms; Appetitive Behavior; Area; Behavior; Behavioral; Behavioral Model; Body Surface; Brain; Breathing; Carbon Dioxide; Chemicals; Communication; Communities; Complex; Computing Methodologies; Conflict (Psychology); Cues; Culicidae; Data; Decision Making; Education; Electrophysiology (science); Elements; Engineering; Environment; Environmental Wind; Exhibits; Female; Flying body movement; Goals; Head; Heating; Human; Individual; Insecta; K-12 Education; Laboratories; Lead; Left; Location; Methods; Modality; Modeling; Motor; Movement; Nervous system structure; Neurons; Normal Statistical Distribution; Odors; Physiology; Postdoctoral Fellow; Preparation; Process; Property; Psychophysics; Recording of previous events; Research; Resources; Sensory; Sensory Process; Shapes; Signal Transduction; Site; Source; Stimulus; Structure; Temperature; Time; Training; Variant; Vision; Visual; Weight; Work; approach behavior; base; behavioral outcome; behavioral response; computational neuroscience; design; disease transmission; experience; feeding; graduate student; human disease; information model; millisecond; multisensory; neuromechanism; novel; outreach; relating to nervous system; research study; response; sensor; sensory input; sensory system; simulation; social; statistics; teacher; theories; undergraduate student; vector

DESCRIPTION (provided by applicant): This project addresses the fundamental question: how does the history of sensory experience affect behavioral decision-making? We address this problem in the neuroethological context of mosquito host seeking, in which the presence of thermal and carbon dioxide signals trigger and direct search behavior. This project has several novel aspects. It will quantitatively explore this synergistic stimulus interaction in the context f a natural behavior and develop models for multisensory integration based both on behavioral and neural data. It will address the spatial variations in the statistical structure of olfactory and thermal stimuli through recordings and direct numerical simulations, and examine whether the universal properties of turbulently advected scalar fields can provide sensory evidence for source location and shape neural responses. We will obtain novel neural recordings in response to multiple time-varying inputs. By a developing tethered flight preparation for mosquitoes, we will be able to record neural activity during constrained flight and directly relate sensory neural responses to behavioral outcomes. The results from this project may help in the design of noninvasive mosquito repellents or attractants and so have an impact on disease transmission. The work may also have impact beyond insect physiology in the design of algorithms for novel sensors in the olfactory domain. Additional broader impacts from this project arise from educational and community engagement through interdisciplinary training of undergraduate and graduate students and postdoctoral fellows; active involvement of our research groups in the broader goals of integrated education and research experiences in the areas of Computational Neuroscience and Neural Engineering through new campus-wide initiatives; communication of our results to the community through a wide variety of social media; and participation in outreach activities to teachers and K-12 classrooms.

描述（由申请人提供）：该项目解决了一个基本问题：感官经验的历史如何影响行为决策？我们在寻求蚊子宿主的神经伦理学环境中解决了这个问题，其中热和二氧化碳信号的存在触发和直接搜索行为。该项目有几个新颖的方面。它将在自然行为上进行定量探索这种协同刺激的相互作用，并为基于行为和神经数据的多感官整合而开发模型。它将通过记录和直接的数值模拟来解决嗅觉和热刺激的统计结构的空间变化，并检查湍流预先前流标量场的通用性能是否可以为源位置和形状神经反应提供感官证据​​。我们将获得新的神经记录，以响应多个时间变化的输入。通过开发的蚊子的束缚飞行准备，我们将能够在受约束飞行过程中记录神经活动，并直接关联感觉神经 对行为结果的反应。该项目的结果可能有助于设计非侵入性蚊子或吸引剂，因此对疾病传播产生影响。这项工作还可能在嗅觉域中新型传感器的算法设计中具有超出昆虫生理的影响。该项目的其他更广泛的影响是通过对本科生和研究生以及博士后研究员的跨学科培训引起的教育和社区参与。我们的研究小组积极参与通过新校园倡议的计算神经科学和神经工程领域的综合教育和研究经验的更广泛的目标；通过各种社交媒体向社区沟通我们的结果；并参加教师和K-12教室的外展活动。