2013 Stress Proteins in Growth, Development & Disease Gordon Research Conference

2013 生长、发育中的应激蛋白

• 批准号: 8597489
• 负责人: JUDITH FRYDMAN
• 金额: $ 3.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8597489
• 关键词: Affect; African American; Aging; Alzheimer' s Disease; Area; Biochemical; Biological Models; Biology; Cattle; Cell Proliferation; Cells; Cellular biology; Collaborations; Commit; Communities; Country; Creutzfeldt-Jakob Syndrome; Data; Defect; Development; Devices; Disease; Ensure; Environment; Equilibrium; Europe; Evaluation; Gender; Gene Activation; Gene Expression; Generations; Genes; Growth and Development function; Health; Heat shock proteins; Homeostasis; Human; Huntington Disease; Infection; Inflammation; Intervention; Lead; Light; Link; Longevity; Maintenance; Metabolism; Michigan; Molecular; Molecular Chaperones; Names; Neurodegenerative Disorders; Oral; Organism; Oxidative Stress; Parkinson Disease; Participant; Physiological; Physiology; Plants; Play; Postdoctoral Fellow; Protein Conformation; Protein Dynamics; Protein-Folding Disease; Proteins; Proteome; Radiation; Regulation; Request for Applications; Research; Research Personnel; Resort; Role; Schedule; Science; Scientist; Series; Shapes; Signal Transduction; Site; Snow; Sodium Chloride; Stress; Structure; System; Techniques; Temperature; Time; Ubiquitin; Underrepresented Minority; Universities; Vermont; Water Stress; Woman; Work; abstracting; age group; age related; base; biological adaptation to stress; graduate student; human disease; meetings; microbial; multicatalytic endopeptidase complex; nervous system disorder; polyglutamine; polypeptide; posters; preference; prion-based; programs; protein folding; protein function; public health relevance; research and development; stress protein; symposium; transcription factor

DESCRIPTION (provided by applicant): The cellular proteome is constantly exposed to a wide variety of toxic stresses. These include external stresses, such as elevated temperatures, radiation damage and pharmacological agents as well as physiological stresses encountered during cellular proliferation, differentiation, inflammation and aging. In all organisms, inductionof the stress response is essential for the maintenance of protein homeostasis and modulation of the stress response plays a critical role in life-span regulation and aging-related diseases such as Alzheimer's, Parkinson's and Huntington's disease. The 2013 Gordon Conference on "Stress Proteins in Growth, Development & Disease" is shaping up to be one of the most exciting and important meetings in this research area. It will highlight the many cutting edge advances in the field, emphasizing a broad range of topics, including exciting developments related to stress sensing, signaling, and gene expression, diseases of protein folding and conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection and pathophysiological states, the cell biology of stress, and the roles of stress in aging. This conference, which is the seventh in this series, will be held July 7th-12th at the Mount Snow Resort in West Dover, Vermont. The chair of this meeting is Dr. Judith Frydman (Stanford University, Stanford, CA) and the co-chair is Dr. Ursula Jakob (University of Michigan, Ann Arbor, MI). Thus far, 34 internationally recognized speakers have committed to attending and speaking at the 2013 meeting, including 9 women and one African- American. Moreover, significant effort will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 10 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under-represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 200 to facilitate effective interactions and discussions. The formal scientific program together with more informal discussions will enhance the dissemination of new information and the formation of new collaborations, which are invaluable for deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

描述（由申请人提供）：细胞蛋白质组不断暴露于各种毒性应激。这些包括外部应激，例如高温、辐射损伤和药物，以及细胞增殖、分化、炎症和衰老过程中遇到的生理应激。在所有生物体中，应激反应的诱导对于维持蛋白质稳态至关重要，并且应激反应的调节在寿命调节和衰老相关疾病（例如阿尔茨海默病、帕金森病和亨廷顿病）中发挥着关键作用。 2013 年戈登会议“生长、发育和疾病中的应激蛋白”即将成为该研究领域最激动人心和最重要的会议之一。它将突出该领域的许多前沿进展，强调广泛的主题，包括与应激传感、信号传导和基因表达、蛋白质折叠和构象疾病、应激基因在代谢、生长和发育中的作用相关的令人兴奋的发展、感染和病理生理状态的应激基因调节、应激的细胞生物学以及应激在衰老中的作用。本次会议是该系列的第七次会议，将于 7 月 7 日至 12 日在佛蒙特州西多佛的滑雪山度假村举行。本次会议的主席是 Judith Frydman 博士（斯坦福大学，加利福尼亚州斯坦福），联合主席是 Ursula Jakob 博士（密歇根大学，密歇根州安娜堡）。迄今为止，已有 34 名国际知名演讲者承诺出席 2013 年会议并在会上发言，其中包括 9 名女性和 1 名非裔美国人。此外，我们将做出巨大努力来增加与会者的多样性，以吸引更多人参加会议。 科学家们进入应激蛋白领域，并催化新合作的形成。为此，我们已准备好时间表，将从提交海报展示的摘要中选出 10 个发言位置，并将优先考虑年轻科学家和代表性不足群体的科学家。会议日程也将准备好，以确保应激生物学和不同模型系统中新出现的主题得到平等的代表。此外，会议出席人数将“上限”为200人，以促进有效的互动和讨论。正式的科学计划加上更多的非正式讨论将加强新信息的传播和新合作的形成，这对于更深入地了解应激蛋白在人类健康、衰老和疾病中的多功能作用非常宝贵。