2011 Stress Proteins in Growth, Development and Disease GRC

2011 生长、发育和疾病 GRC 中的应激蛋白

基本信息

批准号：
8193579
负责人：
JUDITH FRYDMAN
金额：
$ 1.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-06-15 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8193579
关键词：
Affect African American Age Aging Alzheimer&apos s Disease Area Biochemical Biological Models Biology Cattle Cell Aging Cells Cellular Stress Response Cellular biology Collaborations Commit Communities Country Creutzfeldt-Jakob Syndrome Data Defect Degenerative Disorder Development Disease Ensure Environment Europe Evaluation Exhibits Finland Gene Activation Gene Expression Generations Genes Growth and Development function Health Heat shock proteins Human Huntington Disease Infection Intervention Italy Lead Life Light Link Malignant Neoplasms Metabolic Diseases Metabolism Molecular Molecular Chaperones Names Neurodegenerative Disorders Neurons Nutrient Oral Organism Oxidative Stress Parkinson Disease Participant Pathway interactions Physiological Physiology Plants Play Postdoctoral Fellow Process Protein Dynamics Proteins Recording of previous events Regulation Request for Applications Research Research Personnel Resort Role Schedule Science Scientist Series Signal Transduction Site Sodium Chloride Stress Structure System Techniques Time Ubiquitin Underrepresented Minority Universities Water Stress Woman Work abstracting age group age related base biological adaptation to stress cell age graduate student human disease meetings microbial multicatalytic endopeptidase complex nervous system disorder polyglutamine polypeptide posters preference prevent prion-based protein folding protein function rapid growth stress protein symposium transcription factor

项目摘要

DESCRIPTION (provided by applicant): The ability of organisms to withstand stress is critical for survival, and there is a growing appreciation that cellular stress responses are vital during growth and development. In fact, an increasing number of human diseases-particularly those affecting neurons-arise from defects in stress response pathways or from the inability of stress proteins to protect cells. Stress response pathways have also been linked to ageing, infection, cancer, and metabolic diseases. Not surprisingly, then, significant efforts to modulate the stress response have been taken by biomedical researchers. Therefore, it is critical that a forum is provided to assemble scientists who seek to connect the mechanisms underlying human diseases with the regulation of stress genes and with stress protein function. One of the premier forums for this unique assembly is the Stress Proteins in Growth, Development and Disease Gordon Research Conference (GRC). The next conference, which is the sixth in this series, will be held from July 17th - July 22nd, 2011, at the Il Ciocco Hotel & Resort, Lucca (Barga), Italy. The Chair for this meeting is Lea Sistonen (Ebo Akademi University, Turku, Finland) and the Vice-Chair is Judith Frydman (Stanford University, Stanford, CA). The Il Ciocco Hotel has a long history in supporting GRCs conferences. Thus far, 30 internationally recognized speakers have committed to attending and speaking at the 2011 meeting, including 10 women and one African-American. Nevertheless, significant efforts will be undertaken to increase the diversity of meeting attendees, to bring more scientists into the stress protein field, and to catalyze the formation of new collaborations. To this end, the schedule has been prepared so that 16 speaking slots will be chosen from abstracts submitted for poster presentations, and preference will be given to younger scientists and to those from under- represented groups. The meeting schedule will also be prepared to ensure that new and emerging themes in stress biology and different model systems are equally represented. In addition, meeting attendance will be "capped" at 150 to facilitate effective interactions and discussions. Overall, we seek to enhance the dissemination of cutting-edge advances and the formation of new collaborations in the stress protein field. This, in turn, will lead to advances and broaden our understanding of the roles of stress proteins in human health, aging, and disease. PUBLIC HEALTH RELEVANCE: Cells-especially neurons-live under harsh conditions. There are times when cells are starved for nutrients, times when cells need to exhibit rapid growth, and times when cells are exposed to toxic agents. Cells may also express misshapen proteins, as occurs in Alzheimer's, Huntington's, and Parkinson's disease. However, to offset the dangerous consequences of stress, which can lead not only to disease but also to ageing, cells produce specific proteins to protect themselves. The 2011 Gordon Research Conference, entitled 3Stress Proteins in Growth, Development, and Disease4, brings together scientists who study the link between stress and human disease, and provides a unique forum for researchers in this field to assemble and identify new avenues to prevent stress-related diseases and degenerative processes such as aging.

描述（由申请人提供）：生物体承受压力的能力对于生存至关重要，并且人们越来越认识到细胞压力反应在生长和发育过程中至关重要。事实上，越来越多的人类疾病，特别是那些影响神经元的疾病，都是由应激反应途径的缺陷或应激蛋白无法保护细胞引起的。压力反应途径也与衰老、感染、癌症和代谢疾病有关。因此，生物医学研究人员为调节应激反应做出了重大努力，这并不奇怪。因此，提供一个论坛来聚集那些寻求将人类疾病的机制与应激基因的调节和应激蛋白功能联系起来的科学家是至关重要的。这一独特大会的主要论坛之一是生长、发育和疾病中的应激蛋白戈登研究会议 (GRC)。下一次会议是该系列的第六次会议，将于 2011 年 7 月 17 日至 22 日在意大利卢卡（巴尔加）的 Il Ciocco Hotel & Resort 举行。本次会议的主席是 Lea Sistonen（芬兰图尔库埃博学术大学），副主席是 Judith Frydman（加利福尼亚州斯坦福大学）。 Il Ciocco 酒店在支持 GRC 会议方面有着悠久的历史。迄今为止，已有 30 名国际知名演讲者承诺出席 2011 年会议并在会上发言，其中包括 10 名女性和一名非裔美国人。尽管如此，我们仍将做出重大努力来增加与会者的多样性，让更多的科学家进入应激蛋白领域，并促进新合作的形成。为此，我们已准备好时间表，将从提交海报展示的摘要中选出 16 个发言位置，并将优先考虑年轻科学家和来自代表性不足群体的科学家。会议日程也将准备好，以确保应激生物学和不同模型系统中新出现的主题得到平等的代表。此外，会议出席人数将“上限”为150人，以促进有效的互动和讨论。总体而言，我们寻求加强应激蛋白领域前沿进展的传播和新合作的形成。反过来，这将带来进步并拓宽我们对应激蛋白在人类健康、衰老和疾病中的作用的理解。公共卫生相关性：细胞，尤其是神经元，生活在恶劣的条件下。有时细胞会缺乏营养，有时细胞需要快速生长，有时细胞会暴露于有毒物质。细胞还可能表达畸形蛋白质，如阿尔茨海默病、亨廷顿病和帕金森病中所发生的那样。然而，为了抵消压力带来的危险后果（压力不仅会导致疾病，还会导致衰老），细胞会产生特定的蛋白质来保护自己。 2011 年戈登研究会议，题为“3 生长、发育和疾病中的压力蛋白”4，汇集了研究压力与人类疾病之间联系的科学家，并为该领域的研究人员提供了一个独特的论坛，以聚集和确定预防压力的新途径。相关疾病和退化过程，例如衰老。