Growth Hormone and Cardiovascular Disease

生长激素与心血管疾病

基本信息

批准号：
8821397
负责人：
Karen K Miller
金额：
$ 12.06万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-08-20 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8821397
关键词：
Adipocytes Affect Aging Apolipoproteins B Blood Body Composition Bone Density Bone Marrow Bone Marrow Stem Cell C-reactive protein Cardiovascular Diseases Center for Translational Science Activities Clinical Clinical Research Complication Data Deposition Development Dose Educational process of instructing Endocrine Ensure Environment Epidemic Faculty Fatty acid glycerol esters Fellowship Program Finite Element Analysis Fracture Funding General Hospitals Goals Grant Homeostasis Hormones Individual Inflammatory Insulin Insulin-Like Growth Factor I Lead Leadership Lipids Lipoproteins Liver Magnetic Resonance Spectroscopy Maintenance Massachusetts Mediating Mediator of activation protein Medicine Menopause Mentors Mentorship Mesenchymal Midcareer Investigator Award in Patient-Oriented Research Muscle N.I.H. Research Support Normal Range Obesity Osteoblasts Osteocalcin Osteogenesis Osteoporosis Pathway interactions Pharmaceutical Preparations Physiological Physiology Pituitary Gland Play Protocols documentation Publishing Qualifying Regulation Relative (related person)Research Research Personnel Research Project Grants Risk Factors Role Serum Skeleton Somatotropin Techniques Thick Time Training United States National Institutes of Health Vitamin D Vitamin D2 Weight Woman abdominal fat base bone bone health bone loss bone mass bone strength career career development cytokine growth hormone deficiency improved interest lean body mass medical schools member men muscle form new therapeutic target novel osteoblast differentiation patient oriented research professor programs public health relevance skeletal skills stem cell differentiation success wasting

项目摘要

DESCRIPTION (provided by applicant): The scientific goal of this project is to investigate the role of relative growth hormone (GH) deficiency in the etiopathology of bone loss in obese men and women, and the mechanisms by which GH may affect bone microarchitecture and strength. The candidate is an Associate Professor of Medicine at Harvard Medical School and a faculty member at Massachusetts General Hospital who is deeply committed to and highly qualified for a career in patient-oriented research and to mentor new clinician investigators. She has an outstanding record of patient-oriented research (POR) and mentoring during the first K24 grant period. The career development goal of this K24 competitive renewal application is to support the candidate's continued professional development as a POR mentor of fellows and junior faculty with her long-term goal of developing independent POR researchers. The candidate's specific short-term mentoring objectives are: 1) to attract and train new trainees, 2) assist her current mentees to obtain K and R grant funding, to develop their own POR focuses and assist with all other aspects of transitioning to independent careers focused on POR, 3) acquire additional mentoring skills and 3) continue and expand teaching in courses that reach a large number of trainees interested in pursuing POR careers. The candidate's NIH grants will form the basis of research project support for trainees. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and trainees from a number of other departments. The institutional environment is outstanding at the MGH and Harvard Medical School, with an extremely strong Department of Medicine, a Clinical Translational Science Center grant through Harvard Medical School, and a Clinical Research Program at the MGH, all of which offer a myriad of didactic opportunities, facilities and support. The Department of Medicine has made a strong commitment to the candidate, including protected time and dedicated space. The Midcareer Investigator Award in Patient-Oriented Research is an ideal mechanism to ensure the necessary support to protect time for mentorship for this outstanding mentor, who otherwise would have to increase her clinical and administrative responsibilities, and to ensure the candidate's continued success as a mentor and clinical researcher.

描述（由申请人提供）：该项目的科学目标是调查相对生长激素（GH）缺乏在肥胖男性和女性骨质流失病因病理学中的作用，以及 GH 影响骨微结构和强度的机制该候选人是哈佛医学院的医学副教授和马萨诸塞州总医院的教员，她致力于以患者为导向的研究，并在指导新的临床医生研究人员方面拥有出色的职业记录。她在患者方面有着出色的记录。面向第一个 K24 资助期间的研究 (POR) 和指导本 K24 竞争性更新申请的职业发展目标是支持候选人作为研究员和初级教师的 POR 导师的持续专业发展，其长期目标是发展独立的 POR。候选人的具体短期指导目标是：1) 吸引和培训新学员，2) 帮助当前的学员获得 K 和 R 拨款资金，发展他们自己的 POR 重点并协助其所有其他方面。过渡到专注于 POR 的独立职业，3) 获得额外的指导技能，3) 继续并扩大课程教学，覆盖大量有兴趣追求 POR 职业的学员。候选人的 NIH 资助将构成为学员提供研究项目支持的基础。该候选人在国家级指导方面拥有领导记录，并在马萨诸塞州总医院 (MGH) 内分泌奖学金计划中指导学员以及来自其他许多部门的学员方面拥有成功的记录。 MGH 和哈佛医学院拥有极其强大的医学系、哈佛医学院资助的临床转化科学中心以及 MGH 的临床研究项目，所有这些都提供了无数的医学教学机会、设施和支持。对候选人做出了坚定的承诺，包括以患者为导向的研究中的职业生涯中期研究员奖是一个理想的机制，可以确保为这位杰出导师提供必要的支持，以保护他的指导时间，否则他将不得不增加。她的临床和行政责任，并确保候选人作为导师和临床研究员持续取得成功。