Bio-Layer Interferometry (BLI) Octet R8

生物层干涉测量 (BLI) 八位字节 R8

• 批准号: 10632961
• 负责人: Maryam Raeeszadeh Sarmazdeh
• 金额: $ 31.28万
• 依托单位: UNIVERSITY OF NEVADA RENO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-15 至 2024-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10632961
• 关键词: Address; Award; Biosensing Techniques; Centers of Research Excellence; DNA-Protein Interaction; Development; Diagnosis; Engineering; Funding; Institution; Interferometry; Medicine; Neurosciences; Nevada; Proteins; Request for Proposals; Research Personnel; Science; Therapeutic; Time; United States National Institutes of Health; college; drug discovery; high throughput screening; imaging facilities; instrument; interdisciplinary collaboration; molecular imaging; nanoparticle; small molecule

Project Summary/Abstract This proposal requests funding for an Octet R8 to support NIH Institutional Development Award (IDeA) centers in the state of Nevada and NIH-funded researchers. A significant portion of the instrument time would be to address the needs of NIH-funded investigators across the campus via interdisciplinary collaborations and support between colleges of engineering, science, and medicine. The Octet R8 will also provide support for the Nevada INBRE, Integrative Neuroscience Center of Biomedical Research Excellence (COBRE) and the Cellular, Molecular Imaging Center funded by NIH. The Octet R8 will allow researchers to perform new types of biosensing, drug discovery, and diagnosis including protein-protein, protein-small molecule, protein nanoparticles, and protein-DNA interaction studies in real-time and high-throughput screening of potential therapeutics, and sensitive biomolecular sensing application.

项目概要/摘要 该提案请求为 Octet R8 提供资金以支持 NIH 机构发展奖 (IDeA) 内华达州中心和 NIH 资助的研究人员。很大一部分 仪器时间将用于满足 NIH 资助的整个校园研究人员的需求 通过工程学院、科学学院和大学之间的跨学科合作和支持 药品。 Octet R8 还将为 Nevada INBRE、Integrative 神经科学生物医学卓越研究中心 (COBRE) 和细胞、分子 影像中心由 NIH 资助。 Octet R8 将允许研究人员执行新型 生物传感、药物发现和诊断，包括蛋白质-蛋白质、蛋白质-小分子、 蛋白质纳米颗粒以及蛋白质-DNA 相互作用的实时高通量研究 潜在治疗方法的筛选和敏感的生物分子传感应用。