Growth Hormone and Cardiovascular Disease

生长激素与心血管疾病

• 批准号: 8307362
• 负责人: Karen K Miller
• 金额: $ 20.11万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-20 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8307362
• 关键词: Acute; Adipose tissue; Alteplase; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Cause of Death; Center for Translational Science Activities; Central obesity; Chronic; Clinical; Clinical Investigator; Clinical Research; Developed Countries; Development; Discipline; Dose; Endocrine; Ensure; Environment; Faculty; Fatty acid glycerol esters; Fellowship Program; Fibrinogen; Funding; Gender; General Hospitals; Goals; Grant; Hormones; Insulin; Insulin Resistance; Leadership; Lipids; Lipoprotein (a); Lipoproteins; Massachusetts; Medial; Mediating; Medicine; Mentors; Midcareer Investigator Award in Patient-Oriented Research; National Heart, Lung, and Blood Institute; Obesity; Public Health; Recombinants; Relative (related person); Research; Research Personnel; Risk Marker; Role; Skeletal Muscle; Somatotropin; Source; Thick; Time; Training; United States National Institutes of Health; Vasodilation; Visceral; Woman; abdominal fat; base; cardiovascular risk factor; career; career development; growth hormone deficiency; intrahepatic; medical schools; men; muscle form; patient oriented; programs; success

DESCRIPTION (provided by applicant): The scientific goal of this proposal is to investigate the effects of relative growth hormone deficiency and replacement on body composition and cardiovascular risk markers in men and women with abdominal obesity. The career development goal of this application is to support the candidate's professional development as a clinical investigator and successful mentor for fellows and junior faculty in patient-oriented clinical research by providing sufficient time for research and mentoring activities. The mentoring goal of this application is to facilitate the training of fellows and junior faculty in clinical research to form the basis of independent careers. The candidate's NHLBI-funded R01 grant investigating the effects of growth hormone replacement on body composition and cardiovascular risk markers in viscerally adipose men and women with relative growth hormone deficiency will form the basis for the training plan of the grant. Additional research opportunities are available in the form of ongoing studies that are funded by a number of other sources. The candidate has a record of leadership in mentoring on a national level and a successful track record of mentoring trainees in the Massachusetts General Hospital (MGH) Endocrine Fellowship program and other disciplines. The Institutional environment at the MGH, with a strong and diverse Medicine Department, Clinical Translational Science Center grant through Harvard Medical School, and Clinical Research Program, is outstanding. The Department of Medicine at the MGH has made a substantial commitment, including 90% protected time and dedicated space, toward the candidate's development as a clinical researcher responsible for training fellows and junior faculty. The Midcareer Investigator Award in Patient Oriented Research is an ideal mechanism to ensure the necessary support to reduce clinical and administrative responsibilities, and ensure the candidate's continued success as a mentor and clinical researcher. Project Narrative: Cardiovascular disease is the leading cause of death and illness in developed countries. This proposal investigates the role of low growth hormone levels as a possible hormone mechanism underlying the increased cardiovascular risk in women and men with abdominal adiposity and thus could have significant public health implications.

描述（由申请人提供）：该提案的科学目标是研究相对生长激素缺乏症和替代对腹部肥胖症男性和女性身体成分和心血管风险标志物的影响。该应用程序的职业发展目标是通过为研究和指导活动提供足够的时间来支持候选人作为临床研究者和成功的临床教师的专业发展。该应用的指导目标是促进临床研究中的研究员和初级教师的培训，以构成独立职业的基础。该候选人由NHLBI资助的R01赠款调查了生长激素替代者对具有相对生长激素缺乏症的内脏脂肪脂肪脂肪中的人体成分和心血管风险标志物的影响，将构成赠款培训计划的基础。还以许多其他来源资助的正在进行的研究的形式获得了其他研究机会。该候选人在国家一级指导的领导能力记录以及在马萨诸塞州综合医院（MGH）内分泌奖学金计划和其他学科的成功指导学员的成功记录中。 MGH的机构环境具有强大而多样化的医学部门，通过哈佛医学院通过临床转化科学中心赠款以及临床研究计划。 MGH的医学系已作出了重大承诺，包括90％的受保护时间和专用空间，作为负责培训研究员和初级教师的临床研究人员的候选人发展。以患者为导向研究的中级研究员奖是确保减少临床和行政职责的必要支持的理想机制，并确保候选人作为导师和临床研究人员的持续成功。 项目叙述：心血管疾病是发达国家死亡和疾病的主要原因。该提案调查了低生长激素水平作为腹部肥胖男性和男性心血管风险增加的激素机制的作用，因此可能对公共卫生产生重大影响。