Application of Nanogel-modified Resins for Improved Polymeric Dental Materials

纳米凝胶改性树脂在改进高分子牙科材料中的应用

• 批准号: 8373123
• 负责人: JEFFREY W. STANSBURY
• 金额: $ 37.15万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8373123
• 关键词: Address; Adhesions; Adhesives; Ammonium; Anti-Bacterial Agents; Binding Sites; Chemistry; Clinical; Composite Dental Resin; Composite Resins; Dental; Dental Amalgam; Dental Enamel; Dental Materials; Dentin; Dentists; Development; Drug Formulations; Equilibrium; Esthetics; Failure; Filler; Film; Fracture; Generic Drugs; Goals; Individual; Matrix Metalloproteinases; Mechanics; Methacrylates; Modeling; Modification; Molecular Weight; NanoGel; Optics; Oral; Oral health; Oxygen; Patients; Performance; Phase; Pit and Fissure Sealants; Plant Resins; Polymers; Property; Relative (related person); Resistance; Route; Solutions; Stress; Structure; Surface; Suspension substance; Suspensions; Swelling; Techniques; Time; Viscosity; Visit; antimicrobial; bactericide; base; composite restoration; crosslink; dental resin; design; improved; interest; macromolecule; meetings; monomer; nanoscale; novel; particle; polymerization; polymerization shrinkage; polymerization stress; practical application; restoration; restorative composite; restorative dentistry; restorative treatment; seal

DESCRIPTION (provided by applicant): With a majority of the more than 100,000 million dental restorative treatments performed in the US each year involving the placement of resin-bonded composite materials, and the acknowledgement that a large portion of a dentist's time is consumed with revising and replacing these restorations, there is a clear need for materials with improved clinical performance. Composite restoratives not only hold an esthetic advantage over dental amalgams, but they offer a means to adhesively bond the restoration to dentin and enamel. However, due to polymerization shrinkage stresses that challenge this critical interface from the time of placement, a strong, intact margin can not currently be reliably obtained. A highly versatile technique has been developed recently for preparing nano-scale (5 - 100 nm) polymeric particles with control over branching, chemistry and reactive site placement. These reactive nanogels can be dispersed readily at high concentrations in secondary monomers, which then infiltrate and subsequently copolymerize with the prepolymer additives. This approach has provided substantial reductions in polymerization shrinkage and stress, as well as a demonstrated ability to improve the strength of a model dental resin and composite. The proposed project would extend the positive preliminary results into practical examples of highly filled, low stress, nanogel-modified composites for restorative applications while also developing new sealant materials that rely on interpenetrating polymer networks to achieve dramatically reduced levels of free monomer during placement. Bioactive sealants based on nanogels that display anti-bacterial and potentially MMP-inhibiting properties will also be developed and demonstrated. The application is constructed around three aims: i) fundamental studies of nanogel synthesis designed to produce well controlled nanogel structures with predictable properties with a primary focus on a balance between high nanogel contents in monomeric matrices with practically useful viscosities and optical properties; ii) application of nanogels in dental composites where greater than proportional reductions in stress, relative to the nanogel content, will be sought while also improving the fracture toughness of potentially bulk filling composites that combine high loading levels of both nanogel and novel surface-treated inorganic fillers; and iii) use of nanogels to create sealant materials with interpenetrating polymer networks that form with high conversion and a reduced sensitivity to oxygen inhibition, which means more stable materials with much less leachable compound release. The sealant material platform will be further extended to demonstrate the potential bioactivity of polymers with chemically integrated nanogels that convey bactericidal and MMP- inhibition properties. PUBLIC HEALTH RELEVANCE: There are over 100 million dental restorations placed in the US each year and most of these are resin-bonded composite materials which provide an excellent esthetic alternative to dental amalgams but also suffer from relatively high failure/replacement rates. A generic means has been devised to significantly improve a variety of physical and mechanical properties of dental polymeric materials based on modifications to the polymer network structure. Further, the same materials-based approach will be applied to improve the overall conversion and stability of dental sealants, which are also widely used in a preventative mode. Because of the very large numbers of patients who receive sealants and composite restorations, the predicted enhanced clinical performance and long-term reliability that is anticipated to accompany the less technique-sensitive placement of these materials will generate a substantial return in terms of fewer patient visits and improved overall oral health.

描述（由申请人提供）：美国每年进行的超过 1000 亿次牙科修复治疗中，大部分都涉及放置树脂粘合复合材料，并且承认牙医的大部分时间都花在了修改上为了取代这些修复体，显然需要具有改善临床性能的材料。复合修复体不仅比牙科汞合金具有美观优势，而且提供了一种将修复体粘合到牙本质和牙釉质的方法。然而，由于聚合收缩应力从放置时起就对这一关键界面提出了挑战，目前无法可靠地获得坚固、完整的边缘。最近开发了一种高度通用的技术，用于制备纳米级（5 - 100 nm）聚合物颗粒，并控制支化、化学和反应位点的放置。这些反应性纳米凝胶可以很容易地以高浓度分散在第二单体中，然后渗透并随后与预聚物添加剂共聚。这种方法大大减少了聚合收缩和应力，并显示出提高牙科树脂模型和复合材料强度的能力。拟议的项目将把积极的初步结果扩展到用于修复应用的高填充、低应力、纳米凝胶改性复合材料的实际例子，同时还开发依赖互穿聚合物网络的新型密封剂材料，以在放置过程中显着降低游离单体的水平。基于纳米凝胶的生物活性密封剂具有抗菌和潜在的 MMP 抑制特性，该密封剂也将得到开发和论证。该应用程序围绕三个目标构建：i）纳米凝胶合成的基础研究，旨在生产具有可预测特性的良好控制的纳米凝胶结构，主要关注具有实用粘度和光学特性的单体基质中高纳米凝胶含量之间的平衡； ii) 纳米凝胶的应用 牙科复合材料将寻求相对于纳米凝胶含量更大程度地减少应力，同时提高潜在散装填充复合材料的断裂韧性，该复合材料结合了高负载水平的纳米凝胶和新型表面处理无机填料； iii) 使用纳米凝胶来制造具有互穿聚合物网络的密封剂材料，该材料具有高转化率和对氧抑制的敏感性降低，这意味着材料更稳定，可浸出化合物的释放要少得多。密封剂材料平台将进一步扩展，以展示具有化学集成纳米凝胶的聚合物的潜在生物活性，这些纳米凝胶具有杀菌和 MMP 抑制特性。 公共健康相关性：美国每年有超过 1 亿颗牙齿修复体，其中大部分是树脂粘合复合材料，它是牙科汞合金的绝佳美学替代品，但失败/更换率也相对较高。已经设计出一种基于对聚合物网络结构的改性来显着改善牙科聚合物材料的各种物理和机械性能的通用方法。此外，同样的基于材料的方法将用于提高牙科密封剂的整体转化率和稳定性，这些密封剂也广泛用于预防模式。由于接受密封剂和复合修复体的患者数量非常多，预计随着这些材料的技术敏感性较低的放置，临床表现和长期可靠性将得到增强，这将在减少患者就诊次数方面产生可观的回报并改善整体口腔健康。