Novel Mechanisms of Fear Reduction Targeting the Biological State of the Developing Brain

针对发育中大脑的生物状态的减少恐惧的新机制

基本信息

批准号：
9002168
负责人：
Dylan Grace Gee
金额：
$ 25.43万
依托单位：
WEILL MEDICAL COLL OF CORNELL UNIV
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-11 至 2016-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9002168
关键词：
17 year old Adolescence Adolescent Adult Affect Age Amygdaloid structure Animals Anxiety Anxiety Disorders Behavior Biological Brain Child Childhood Classification Cognitive Therapy Conditioned Stimulus Cues Data Deltastab Development Diagnostic and Statistical Manual of Mental Disorders Disease Economic Burden Effectiveness Extinction (Psychology)Fright Functional Magnetic Resonance Imaging Galvanic Skin Response Goals Hippocampus (Brain)Human Image Individual Intervention Learning Literature Longevity Measures Mediating Mental disorders Methods Mus Neurobiology Onset of illness Outcome Pathway interactions Patients Play Process Psyche structure Relative (related person)Research Research Domain Criteria Rest Rodent Role Safety Severities Signal Transduction Societies Testing Time Treatment Efficacy Youth adolescent brain development anxiety symptoms anxious base efficacy testing emotion regulation experience flexibility insight learned behavior learning extinction neural circuit novel novel strategies preclinical study prevent psychologic public health relevance response safety testing therapy development

项目摘要

DESCRIPTION (provided by applicant): Adolescence is a peak time for the onset of mental illnesses, with anxiety being the most common disorder and affecting as many as 1 in 10 youth. A core feature of anxiety disorders is difficulty identifying when situations that have been experienced as threatening in the past are currently safe. Despite substantial changes in the neural circuitry supporting emotion regulation and fear extinction across development, interventions for youth are largely based on treatment principles studied and implemented in adulthood. The primary goal of this application is to investigate the efficacy of safety signal learning as a novel method of fear reduction targeting the biological state of the developing brain. Rodent studies have shown that safety signals effectively reduce anxiety to treat and prevent the development of new fears. This learning relies largely on the hippocampus, a region that shows significant development from childhood to adolescence. Yet safety signal learning remains largely unexplored in humans, especially during adolescence when anxiety peaks. The proposed research adapts a paradigm used in animal studies to test the efficacy of safety signals across development in healthy children and adolescents and those with anxiety disorders. Aim 1 will examine the normative development of safety signal learning and related hippocampal-frontoamygdala circuitry across childhood and adolescence. Aim 2 will test safety signal learning for reducing fear among anxious children and adolescents and test the hypothesis that hippocampal-frontoamygdala circuitry deviates from typical development in these individuals. Aim 3 will examine how type and severity of anxiety relate to safety signal learning and hippocampal- frontoamygdala development. Understanding these neurodevelopmental changes and the roles that they play in both the emergence of illness onset and in treatment efficacy is critical to alleviating the high psychological and economic burden that psychiatric disorders have on the individual and on society. This project is expected to have direct implications for the timing and types of intervention for child and adolescent anxiety, fillng a large gap in the current literature.

描述（通过应用程序证明）：青春期是精神疾病的高峰时间，多达十分之一的年轻人。在开发中，干预和年轻人主要是基于在应用中研究和实施的。在焦虑症中，在青春期的发展，在焦虑症中，有重大的发展。青少年和患有焦虑症的人将检查安全信号学习的规范性发展，并在儿童期和青少年时期进行相关的对Amygdala的回路。这些个体的发展。对于儿童和焦虑的定时和类型，在当前文献中填补了RGE空白。