FASEB SRC on Glucose transport: Gateway for metabolic systems Biology

FASEB SRC 关于葡萄糖转运：代谢系统生物学的门户

• 批准号: 8595738
• 负责人: Silvia Corvera
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-08 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8595738
• 关键词: Accounting; Animal Model; Area; Biological; Biological Models; Blood Glucose; Budgets; Cancer Cell Growth; Carbon; Cell Proliferation; Cell model; Cell physiology; Clinical; Colorado; Commit; Complex; Computers; Databases; Development; Disadvantaged; Disease; Energy Metabolism; Energy-Generating Resources; Epidemic; Funding; Generations; Genome; Glucose; Glucose Transporter; Grouping; Growth; Health; Housing; Human; Human body; Individual; Institution; Knowledge; Laboratories; Learning; Length; Maintenance; Malignant Neoplasms; Mammals; Metabolic; Metabolism; Methods; Minority; Monosaccharides; National Institute of Diabetes and Digestive and Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Pathway interactions; Patients; Physiological; Postdoctoral Fellow; Regulation; Research; Research Personnel; Role; Science; Scientist; Services; Signal Transduction; Societies; Sodium; Structure; Students; Systems Biology; Techniques; Technology; Testing; Therapeutic Studies; Travel; United States National Institutes of Health; Work; abstracting; base; cell growth; experience; glucose metabolism; glucose transport; human disease; inhibitor/antagonist; insight; meetings; microbiome; novel strategies; programs; public health relevance; reuptake; supported housing; symposium; tool

DESCRIPTION (provided by applicant): The simple monosaccharide glucose is the primary source of energy and carbon throughout the biological world. In mammals, the circulating concentration of glucose is maintained within a very narrow critical range, and disruption of glucose levels is the central pathophysiological manifestation of Type-2 diabetes. Moreover, glucose-derived energy is parsed into specific cellular functions such as growth, proliferation and maintenance, and cancer cell growth is critically dependent on glucose-dependent pathways. There has been major progress in the field of glucose transport, exemplified by the elucidation of the atomic structure of glucose transporters, and the generation and use of selective inhibitors of glucose reuptake in clinical settings. However, many questions remain, and further impact on disease mechanisms is contingent upon understanding glucose transport within the wider context of energy metabolism and its regulation. This application seeks support for housing and travel for young investigators to attend the 2013 FASEB Science Research Conference "Glucose transport: Gateway for Metabolic Systems Biology" July 14-19, 2013, Snowmass Village, Colorado, USA. For 20 years this conference has been the single most important opportunity for scientists involved in the study of glucose transport to meet face to face to discuss new findings, arising questions, and emerging experimental approaches to the complex problem of glucose transport and its vast physiological repercussion. The specific aims of this conference are 1) To integrate diverse approaches to understanding glucose transport and metabolism within the context of whole-body metabolic complexity and disease, and 2) To attract new investigators into the complex and important field of glucose and energy metabolism. Modern approaches include hypothesis-driven and screen-driven discovery, the later involving the generation of sophisticated databases and tools to enable hypothesis testing. In addition, current concepts of energy metabolism must account for the effects of multiple genomes of the microbiome, interacting at different niches within the human body. Eight sessions spanning from atomic mechanisms to systems biology of glucose transport and energy metabolism are proposed, chaired by experienced, leading investigators in each field. To insure timely discussion of emerging information, approximately 30 percent of the program will be chosen from abstracts, and participation by young investigators and scientists from groups underrepresented in the field will be favored.

描述（由申请人提供）：简单的单糖葡萄糖是整个生物界能量和碳的主要来源。在哺乳动物中，葡萄糖的循环浓度维持在非常窄的临界范围内，葡萄糖水平的破坏是2型糖尿病的主要病理生理学表现。此外，葡萄糖衍生的能量被解析为特定的细胞功能，如生长、增殖和维持，癌细胞的生长严重依赖于葡萄糖依赖性途径。葡萄糖转运领域取得了重大进展，例如葡萄糖转运蛋白的原子结构的阐明，以及临床环境中葡萄糖再摄取选择性抑制剂的产生和使用。然而，仍然存在许多问题，对疾病机制的进一步影响取决于在能量代谢及其调节的更广泛背景下理解葡萄糖转运。此申请为年轻研究人员寻求住房和交通支持，以参加 2013 年 FASEB 科学研究会议“葡萄糖转运：代谢系统生物学的门户”，该会议将于 2013 年 7 月 14 日至 19 日在美国科罗拉多州斯诺马斯村举行。 20年来，这次会议一直是参与葡萄糖转运研究的科学家们面对面讨论新发现、出现的问题以及解决葡萄糖转运复杂问题及其巨大生理影响的新兴实验方法的最重要的机会。本次会议的具体目标是 1) 在全身代谢复杂性和疾病的背景下整合多种方法来理解葡萄糖转运和代谢，2) 吸引新的研究人员进入葡萄糖和能量代谢复杂而重要的领域。现代方法包括假设驱动和屏幕驱动的发现，后者涉及生成复杂的数据库和工具来进行假设检验。此外，当前的能量代谢概念必须考虑微生物组的多个基因组的影响，这些基因组在人体内的不同生态位相互作用。提出了八个会议，涵盖从原子机制到葡萄糖转运和能量代谢的系统生物学，由每个领域经验丰富的领先研究人员主持。为了确保及时讨论新出现的信息，大约 30% 的项目将从摘要中选出，并且来自该领域代表性不足的群体的年轻研究人员和科学家的参与将受到青睐。