FASEB SRC on Glucose Transporters, Signaling and Diabetes

关于葡萄糖转运蛋白、信号传导和糖尿病的 FASEB SRC

基本信息

批准号：
8200163
负责人：
Silvia Corvera
金额：
$ 1.5万
依托单位：
FEDERATION OF AMER SOC FOR EXPER BIOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8200163
关键词：
Adipose tissue Architecture Area Bioenergetics Biology Blood - brain barrier anatomy Brain Carbon Cardiac Muscle Contraction Cell Maintenance Cell membrane Cells Cellular Membrane Clinical Collaborations Complex Defect Dependence Development Diabetes Mellitus Disease Epigenetic Process Funding Glucose Glucose Transporter Glycolysis Growth Housing Human Insulin Insulin Resistance Integral Membrane Protein Knowledge Laboratories Lead Link Maintenance Malignant Neoplasms Membrane Metabolism Minority Movement Muscle Mutate National Institute of Diabetes and Digestive and Kidney Diseases Neurons Non-Insulin-Dependent Diabetes Mellitus Nutritional status Oral Oxidative Phosphorylation Paper Participant Pathogenesis Peripheral Physiological Plasma Play Postdoctoral Fellow Process Production Publishing Research Research Personnel Role Scientist Series Signal Transduction Site Skeletal Muscle Source Structure of beta Cell of islet Students Syndrome Tissues Training Translational Research Travel Woman Work abstracting cancer cell experience glucose metabolism glucose transport glucose uptake interest liver function meetings new technology protein folding symposium

项目摘要

DESCRIPTION (provided by applicant): Through its ability to be metabolized and sensed, glucose fulfills numerous crucial roles in biology. Glucose is the primary source of fuel for energy production in the brain, and its circulating plasma levels are regulated by numerous redundant mechanisms. Glucose is sensed by pancreatic beta cells, which respond by secreting the appropriate amount of insulin to regulate transport of glucose into peripheral tissues. One of the most important links between glucose transport and disease is the development of insulin resistance, a key defect in the pathogenesis of type 2 diabetes, which is manifested by the progressive inability of insulin to induce glucose transport into adipose and muscle tissues. Furthermore, cancer cells have developed unique mechanisms to utilize glucose to support uncontrolled growth. In addition to its critical role in cell and whole body bioenergetics, glucose plays a critical role in the proper folding of proteins, and is thus critical for the maintenance of cellular architecture. All of the aforementioned processes absolutely require the presence and function of glucose transporters (GLUTs), which are transmembrane proteins specialized for the recognition and movement of glucose across membranes. The series of FASEB Summer Research Conferences, initiated in the 1990s with the title "Glucose Transporter Biology" has been a unique venue for scientists involved in the study of glucose transport to meet every two years face to face to discuss new findings, arising questions, and emerging experimental approaches to the complex problem of glucose transport and its vast physiological repercussion. The 2011 FASEB Conference on Glucose Transporters, Signaling and Diabetes aims to gather an ideal mix of investigators comprising leaders in the field of glucose transport, leaders in fields that involve glucose transport, but who typically assist meetings in other areas (e.g. cancer, epigenetics), and new investigators and trainees in this field. New mechanisms will be utilized to maximize interactions between experienced and new investigators and trainees, including integrative directed discussions at the end of oral sessions, and "meet the expert" sessions interspersed between sessions. Funding from NIDDK will be essential for subsidizing travel and housing expenses for as many of these young investigators as possible. The conference will incorporate the diverse interests of attendees by choosing many speakers from submitted abstracts. In addition, we will make special efforts to attract minority scientists, and maintain the traditional participation of about 50% women speakers. PUBLIC HEALTH RELEVANCE: Project Narrative The 2011 FASEB Conference on Glucose Transporters, Signaling and Diabetes aims to gather a group of investigators comprising leaders in the field, as well as new investigators and trainees, to discuss new findings, arising questions, and emerging experimental approaches to the complex problem of glucose transport and its vast physiological repercussion. This topic is highly related to human health, as glucose is the primary source of fuel in the body, and its regulation is disrupted in type 2 diabetes, a disease reaching epidemic levels in our society. Furthermore, cancer cells have developed unique mechanisms to utilize glucose to support uncontrolled growth. Thus, continued collaborative effort in the field of glucose transport is important in understanding and improving human health.

描述（由申请人提供）：通过其代谢和感知的能力，葡萄糖在生物学中发挥着许多关键作用。葡萄糖是大脑产生能量的主要燃料来源，其循环血浆水平受到许多冗余机制的调节。葡萄糖由胰腺β细胞感知，胰腺β细胞通过分泌适量的胰岛素来调节葡萄糖向外周组织的转运来做出反应。葡萄糖转运与疾病之间最重要的联系之一是胰岛素抵抗的发展，这是2型糖尿病发病机制中的一个关键缺陷，其表现为胰岛素逐渐无法诱导葡萄糖转运至脂肪和肌肉组织。此外，癌细胞已经发展出独特的机制来利用葡萄糖来支持不受控制的生长。除了在细胞和全身生物能学中发挥关键作用外，葡萄糖在蛋白质的正确折叠中也发挥着关键作用，因此对于维持细胞结构至关重要。所有上述过程都绝对需要葡萄糖转运蛋白 (GLUT) 的存在和功能，葡萄糖转运蛋白是专门用于跨膜识别和移动葡萄糖的跨膜蛋白。 FASEB 夏季研究会议系列于 20 世纪 90 年代发起，主题为“葡萄糖转运生物学”，为参与葡萄糖转运研究的科学家提供了一个独特的场所，每两年一次面对面讨论新发现、提出的问题、以及针对葡萄糖转运的复杂问题及其巨大的生理影响的新兴实验方法。 2011 年 FASEB 葡萄糖转运蛋白、信号传导和糖尿病会议旨在聚集理想的研究人员组合，其中包括葡萄糖转运领域的领导者、涉及葡萄糖转运领域的领导者，但通常协助其他领域的会议（例如癌症、表观遗传学），以及该领域的新研究人员和受训人员。将利用新机制最大限度地提高经验丰富的和新的研究者和受训人员之间的互动，包括在口头会议结束时进行综合性定向讨论，以及穿插在会议之间的“与专家会面”会议。 NIDDK 的资金对于补贴尽可能多的年轻研究人员的旅行和住房费用至关重要。会议将通过从提交的摘要中选择许多演讲者来融合与会者的不同兴趣。此外，我们将特别努力吸引少数族裔科学家，并保持约50%女性演讲者的传统参与。公共健康相关性：项目叙述 2011 年 FASEB 葡萄糖转运蛋白、信号传导和糖尿病会议旨在聚集一组由该领域的领导者以及新的研究人员和学员组成的研究人员，讨论新发现、出现的问题和新兴实验方法葡萄糖转运的复杂问题及其巨大的生理影响。这个话题与人类健康高度相关，因为葡萄糖是体内燃料的主要来源，而它的调节在 2 型糖尿病（一种在我们社会中达到流行水平的疾病）中受到破坏。此外，癌细胞已经发展出独特的机制来利用葡萄糖来支持不受控制的生长。因此，在葡萄糖转运领域的持续合作对于理解和改善人类健康非常重要。