Forebrain-Cerebellum Interactions in Trace Conditioning

微量调节中的前脑-小脑相互作用

• 批准号: 8596737
• 负责人: MICHAEL D MAUK
• 金额: $ 38.09万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-15 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8596737
• 关键词: Acetylcholine; Affect; Alzheimer' s Disease; Animals; Attention; Attention deficit hyperactivity disorder; Behavior; Behavioral; Cell Nucleus; Cells; Cerebellum; Data; Dementia; Disease; Extinction (Psychology); Eyelid structure; Goals; Health; Infusion procedures; Knowledge; Lateral; Learning; Lesion; Mechanics; Mediating; Memory impairment; Neurons; Oryctolagus cuniculus; Output; Pathway Analysis; Play; Pontine structure; Prefrontal Cortex; Prevention strategy; Primates; Property; Prosencephalon; Role; Savings; Senility; Short-Term Memory; Sorting - Cell Movement; Source; Specificity; Stimulus; System; Testing; Time; Training; Work; age related; basal forebrain; base; behavior influence; classical conditioning; conditioning; disorder prevention; eyelid conditioning; insight; learned behavior; nervous system disorder; neuromechanism; operation; response

DESCRIPTION (provided by applicant): We propose to use trace eyelid conditioning to study the neural mechanisms operating in prefrontal cortex to mediate working memory. We have demonstrated that trace eyelid conditioning in rabbit is a working memory task that involves the persistent activity of the so called "delay cells" of prefrontal cortex. There are many fundamental questions about delay cells and the mechanisms of working memory that have remained unanswered largely owing to limitations of studies in primates: the traditional system for working memory studies. Specifically, working with trace conditioning in rabbits makes it feasible to study the origins of delay cell activity in PFC: what roles are played by learning? what are the inputs to PFC that are necessary for delay cells? Because recordings are feasible in rabbits completely na¿ve to the task, which is not feasible with primates, such questions become feasible and affordable to answer. We will use recordings from PFC neurons to determine how delay cell activity arises and to characterize the rules that govern changes in delay cell responding as task demands are changed. Rabbit studies also make feasible analysis of the pathways projecting to prefrontal cortex that are involved in trace conditioning and delay cell activity. The completion of these studies will therefore yield fundamental new insights into the mechanisms responsible for the formation of working memories and their modulation by changes in environmental demands. Such knowledge will greatly facilitate our ability to develop strategies for the prevention or treatment of a host of neurological disorders that appear to relate to working memory deficits, including attention disorders and age-related dementias.

描述（由适用提供）：我们建议使用痕量眼睑调节来研究在媒体工作记忆前额叶皮层中运行的神经元机制。我们已经证明，兔子中的痕量眼睑调节是一项工作记忆任务，涉及前额叶皮层所谓的“延迟细胞”的持续活动。关于延迟细胞和工作记忆机制的基本问题，由于私人研究的局限性：传统的工作记忆研究系统。具体而言，在兔子中使用痕量调节使研究PFC中延迟细胞活动的起源是可行的：学习扮演了什么角色？延迟细胞所需的PFC输入是什么？由于兔子在兔子中的录音完全是可行的。我们将使用PFC神经元的记录来确定延迟细胞活动的产生方式，并表征随着任务需求的更改而控制延迟细胞响应的规则。兔子研究还可以对投射到痕量调节和延迟细胞活性的前额叶皮层的途径进行可行分析。因此，这些研究的完成将产生基本的新见解，对负责形成工作记忆的机制及其通过环境需求的变化来调节。这些知识将极大地支持我们制定预防或治疗似乎与工作记忆有关的许多神经系统疾病的策略的能力，包括注意力障碍和与年龄相关的痴呆症。