Mechanisms of timing and temporal coding

定时和时间编码机制

基本信息

批准号：
10541159
负责人：
MICHAEL D MAUK
金额：
$ 38.92万
依托单位：
UNIVERSITY OF TEXAS AT AUSTIN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-15 至 2026-11-30
项目状态：
未结题

项目摘要

Project Summary/Abstract: One of the least understood computations in the brain is timing. We propose to combine large-scale simulations with eyelid conditioning experiments to reveal temporal coding mechanisms that underlie the cerebellum’s capacity for timing. The feasibility and power of this approach is facilitated by several related factors. Eyelid conditioning provides the ability to control cerebellar inputs and infer its output. Indeed, cerebellar timing is most clearly revealed in this way. This eyelid conditioning-cerebellum connection makes it possible to test large-scale cerebellar simulations in quantitative and biological relevant ways. There is also a natural synergy arising from combining simulations with experiments when each can be related with the other – simulation results suggest better experiments and interpretation of data, experiments inform simulations and make them more relevant and useful. The proposed studies are based on two relatively new discoveries about cerebellar connectivity: Golgi cells inhibit each other and deep cerebellar nucleus (DCN) neurons send collateral axons back to cerebellar cortex as mossy fibers. Preliminary data from simulations and experiments suggest these two connections confer the cerebellum with its capacity for timing and temporal coding. Simulations suggest specific predictions that can be tested with eyelid conditioning studies that include behavioral analysis, tetrode recordings and opto-genetic silencing of specific neurons. Results will inform more general theories of how neurons and synapses can implement temporal coding.

项目摘要/摘要：大脑中最了解的计算之一是时间安排。我们建议将大规模模拟与眼睑调节实验相结合，以揭示临时编码机制这是小脑计时能力的基础。这种方法的可行性和力量是由几个相关因素。眼睑调节提供了控制小脑输入并推断其输出的能力。的确，小脑时机以这种方式最清楚地揭示了。这种眼睑调节连接可以以定量和生物学相关的方式测试大型小脑模拟。有这也是将模拟与实验相结合的自然协同作用其他 - 模拟结果提出了更好的实验和数据解释，实验会为模拟提供信息。并使它们更相关和有用。拟议的研究基于两个相对较新的发现关于小脑的连通性：高尔基细胞相互抑制，深脑核（DCN）神经元发送作为苔藓纤维的副轴突回到小脑皮层。来自模拟和实验的初步数据建议这两个连接会议小脑，其定时和临时编码能力。模拟提出了可以通过眼睑调节研究测试的具体预测，包括特定神经元的行为分析，四极记录和光遗传沉默。结果将为更多信息提供信息神经元和突触如何实施临时编码的一般理论。