2015 Cerebellum GRC

2015 小脑 GRC

• 批准号: 8985403
• 负责人: MICHAEL D MAUK
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-03 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985403
• 关键词: Address; Area; Ataxia; Autistic Disorder; Brain; Brain region; Cerebellar Diseases; Cerebellum; Collaborations; Communities; Data; Development; Disease; Dyskinetic syndrome; Dyslexia; Dystonia; Environment; Etiology; Fertilization; Fostering; Functional disorder; Goals; Health; Human; Human Development; Human Pathology; Impaired cognition; Individual; Language; Lead; Learning; Length; Link; Maine; Mental disorders; Methods; Modeling; Molecular; Motor; Movement; Nervous System Physiology; Neurosciences; Oral; Outcome; Output; Pathology; Physiology; Process; Production; Research; Research Personnel; Resources; Rest; Science; Scientist; Side; Staging; Structure; Symptoms; Synaptic plasticity; System; Techniques; Time; Underrepresented Minority; Ursidae Family; Work; autism spectrum disorder; career; cellular development; college; design; distraction; experience; insight; interest; meetings; motor disorder; nervous system disorder; novel strategies; outreach; posters; public health relevance; relating to nervous system; symposium

 DESCRIPTION (provided by applicant): The proposal seeks partial support for the third biennial Gordon Research Conference (GRC) on the Cerebellum, to be held at Bates College in Lewiston, Maine, USA, August 9-14, 2015. Powerful new approaches for studying nervous system function at the circuit and systems level have recently been developed and these hold promise for achieving a deep, mechanistic understanding of brain functions. Nowhere is this promise more apparent than for the cerebellum. Although the most obvious symptoms of cerebellar damage are motor, cerebellar function is about much more than generating movements. This can be seen in the way cerebellar dysfunction is associated both with motor disorders (including ataxias, dystonia, and dyskinesia) and with cognitive impairments as well. The cerebellum is implicated in the etiologies of disorders such dyslexia, language production issues and autism spectrum disorder. Cerebellar research has also broken new ground by providing general insights in such areas as brain development, cellular and molecular mechanisms of plasticity, relating synaptic plasticity to learning, computation and computational approaches to brain function. Perhaps the most important influence of cerebellar research on the rest of neuroscience has been illustrating the value of identifying wiring diagrams and focusing interest on input to output transformations. In these ways, keeping up to date on cerebellar research is valuable for both cerebellar researchers and for those with more general interests in the approaches listed above. Despite this, there have been few opportunities for those interested in the cerebellum to meet, discuss their work, to be informed by developments in new methods and by new data on cerebellar pathologies, and to consider implications for broader questions in neuroscience. The aims of the Cerebellum GRC are to provide a venue to accomplish these goals by bringing together scientists from multiple career stages and different backgrounds, to provide them an opportunity to interact closely and to develop scientific relationships that will lead to collaborative work and new approaches to investigating the cerebellum in health and disease. These aims will be achieved by a keynote address on opening night followed by eight sessions of oral presentations over four days presented by leaders in the field and by up-and-coming junior investigators. The organization of the meeting will provide ample discussion time with active facilitation of participation by young scientists an trainees, poster presentations for maximal exposure of all attendees' research, and unstructured time between scientific sessions for in-depth discussions. Inclusion of such sessions as disorders of the cerebellum, human cerebellar function, computational approaches to cerebellar processing and mechanisms of cerebellar development will not only generate healthy exchange of ideas but will also educate investigators about how their work pertains to and can best be brought to bear on the treatment of neurological and mental disorders.

 描述（由申请人提供）：该提案寻求对第三届两年一度的小脑戈登研究会议 (GRC) 的部分支持，该会议将于 2015 年 8 月 9 日至 14 日在美国缅因州刘易斯顿的贝茨学院举行。最近开发了在回路和系统水平上研究神经系统功能的技术，这些技术有望对大脑功能进行深入、机械的理解，这一点在小脑方面最为明显。小脑损伤最明显的症状是运动，小脑功能不仅仅是产生运动，这可以从小脑功能障碍与运动障碍（包括共济失调、肌张力障碍和运动障碍）以及认知障碍相关的方式看出。小脑与阅读障碍、语言产生问题和自闭症谱系障碍等疾病的病因有关，小脑研究也通过提供大脑等领域的一般见解而开辟了新领域。小脑研究对神经科学其他领域最重要的影响可能是阐明了识别接线图和关注输入的价值。通过这些方式，了解小脑研究的最新情况对于小脑研究人员和对上述方法感兴趣的人来说都是有价值的，尽管如此，对于那些对这些方法感兴趣的人来说却很少有机会。小脑 GRC 的目标是提供一个场所来实现这些目标，通过新方法的发展和小脑病理学的新数据来了解其影响。将来自不同职业阶段和不同背景的科学家聚集在一起，为他们提供密切互动的机会并发展科学关系，从而开展协作工作和研究小脑健康和疾病的新方法。这些目标将通过以下方式实现。开幕之夜有主题演讲，随后为期四天的八场口头报告，由该领域的领导者和崭露头角的初级研究人员进行会议的组织将提供充足的讨论时间，并积极促进年轻科学家的参与。学员的海报展示，最大限度地展示所有与会者的研究成果，以及科学会议之间的非结构化时间，以进行深入讨论，包括小脑疾病、人类小脑功能、小脑处理的计算方法和机制。小脑发育不仅会产生健康的思想交流，还会教育研究人员他们的工作如何与神经和精神疾病的治疗相关，并最好地应用于神经和精神疾病的治疗。