2015 Cerebellum GRC

2015 小脑 GRC

• 批准号: 8985403
• 负责人: MICHAEL D MAUK
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-03 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8985403
• 关键词: Address; Area; Ataxia; Autistic Disorder; Brain; Brain region; Cerebellar Diseases; Cerebellum; Collaborations; Communities; Data; Development; Disease; Dyskinetic syndrome; Dyslexia; Dystonia; Environment; Etiology; Fertilization; Fostering; Functional disorder; Goals; Health; Human; Human Development; Human Pathology; Impaired cognition; Individual; Language; Lead; Learning; Length; Link; Maine; Mental disorders; Methods; Modeling; Molecular; Motor; Movement; Nervous System Physiology; Neurosciences; Oral; Outcome; Output; Pathology; Physiology; Process; Production; Research; Research Personnel; Resources; Rest; Science; Scientist; Side; Staging; Structure; Symptoms; Synaptic plasticity; System; Techniques; Time; Underrepresented Minority; Ursidae Family; Work; autism spectrum disorder; career; cellular development; college; design; distraction; experience; insight; interest; meetings; motor disorder; nervous system disorder; novel strategies; outreach; posters; public health relevance; relating to nervous system; symposium

 DESCRIPTION (provided by applicant): The proposal seeks partial support for the third biennial Gordon Research Conference (GRC) on the Cerebellum, to be held at Bates College in Lewiston, Maine, USA, August 9-14, 2015. Powerful new approaches for studying nervous system function at the circuit and systems level have recently been developed and these hold promise for achieving a deep, mechanistic understanding of brain functions. Nowhere is this promise more apparent than for the cerebellum. Although the most obvious symptoms of cerebellar damage are motor, cerebellar function is about much more than generating movements. This can be seen in the way cerebellar dysfunction is associated both with motor disorders (including ataxias, dystonia, and dyskinesia) and with cognitive impairments as well. The cerebellum is implicated in the etiologies of disorders such dyslexia, language production issues and autism spectrum disorder. Cerebellar research has also broken new ground by providing general insights in such areas as brain development, cellular and molecular mechanisms of plasticity, relating synaptic plasticity to learning, computation and computational approaches to brain function. Perhaps the most important influence of cerebellar research on the rest of neuroscience has been illustrating the value of identifying wiring diagrams and focusing interest on input to output transformations. In these ways, keeping up to date on cerebellar research is valuable for both cerebellar researchers and for those with more general interests in the approaches listed above. Despite this, there have been few opportunities for those interested in the cerebellum to meet, discuss their work, to be informed by developments in new methods and by new data on cerebellar pathologies, and to consider implications for broader questions in neuroscience. The aims of the Cerebellum GRC are to provide a venue to accomplish these goals by bringing together scientists from multiple career stages and different backgrounds, to provide them an opportunity to interact closely and to develop scientific relationships that will lead to collaborative work and new approaches to investigating the cerebellum in health and disease. These aims will be achieved by a keynote address on opening night followed by eight sessions of oral presentations over four days presented by leaders in the field and by up-and-coming junior investigators. The organization of the meeting will provide ample discussion time with active facilitation of participation by young scientists an trainees, poster presentations for maximal exposure of all attendees' research, and unstructured time between scientific sessions for in-depth discussions. Inclusion of such sessions as disorders of the cerebellum, human cerebellar function, computational approaches to cerebellar processing and mechanisms of cerebellar development will not only generate healthy exchange of ideas but will also educate investigators about how their work pertains to and can best be brought to bear on the treatment of neurological and mental disorders.

 描述（由适用提供）：该提案寻求对小脑第三次双年期戈登研究会议（GRC）的部分支持，将于2015年8月9日至14日在美国缅因州刘易斯顿市的贝茨学院举行。在巡回赛和系统层面上研究巡回赛和系统层面上有希望的有望实现深度了解的大脑功能的强大新方法。没有比小脑更明显的希望。尽管小脑损伤的最明显症状是运动，但小脑功能远不止于产生运动。这可以看出，小脑功能障碍既与运动障碍（包括共济失调，肌张力障碍和运动障碍）以及认知障碍有关。小脑与此类阅读障碍，语言生产问题和自闭症谱系障碍等疾病的病因有关。小脑研究还通过在脑发育，可塑性的细胞和分子机制，将突触可塑性与学习，计算和计算方法相关的脑功能方面提供一般见解，从而打破了新的基础。小脑研究对其他神经科学的最重要影响也许是说明了识别接线图并将兴趣集中在输入转换上的价值。通过这些方式，对小脑研究的最新作用对于小脑研究人员和对上述方法中具有更普遍兴趣的人都很有价值。尽管如此，对于小脑感兴趣的人来说，很少有机会见面，讨论他们的工作，通过新方法的发展和小脑病理学的新数据来告知他们，并考虑对神经科学中更广泛的问题的影响。小脑GRC的目的是通过将来自多个职业阶段和不同背景的科学家聚集在一起，为他们提供一个紧密互动的机会，并建立科学关系，从而提供协作工作和新方法，从而为健康和疾病研究中的新方法提供机会。这些目标将在开幕之夜的主题演讲中实现，然后在该领域的领导人和新兴的初级调查员提出的四天内进行了八次口头演讲。会议的组织将提供充足的讨论时间，并通过年轻科学家的积极准备，一名受训者的海报演示，以最大程度地接触所有与会者的研究，以及在科学会议之间进行深入讨论之间的非结构化时间。包括小脑疾病，人小脑功能，小脑加工的计算方法以及小脑发育机制等会话不仅会产生健康的思想交换，而且还将教育研究人员的工作与神经和精神分散者的治疗方法。