Johns Hopkins Pediatric Obesity Research and Training Center

约翰·霍普金斯小儿肥胖研究和培训中心

• 批准号: 8786572
• 负责人: Bruce Y Lee
• 金额: $ 318.58万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-22 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8786572
• 关键词: Academic Training; Affect; Applications Grants; Area; Baltimore; Basic Science; Behavior; Behavioral Model; Biological Models; Biology; Body Weight; Child; China; Collaborations; Communities; Complex; Consumption; Data; Development; Doctor of Philosophy; Eating; Educational workshop; Environmental Policy; Environmental Risk Factor; Epidemic; Epidemiologic Methods; Epidemiology; Epigenetic Process; Etiology; Evaluation Research; Faculty; Family; Fertilization; Food; Food Access; Food Supply; Funding; Health Food; Health system; Household; Individual; Institution; International; Intervention; Investigation; Leadership; Literature; Low Income Population; Low income; Mentorship; Methodology; Methods; Minority; Mission; Modeling; Neighborhoods; Obesity; Pilot Projects; Policies; Postdoctoral Fellow; Prevention program; Public Health; Public Health Schools; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Schools; Science; Solid; Solutions; Staging; System; Systems Analysis; Training; Training Programs; Training Support; Training and Education; United States National Institutes of Health; Universities; Ursidae Family; Vision; Work; advanced system; base; career; cohort; cost effective; design; effective intervention; energy balance; experience; high risk; improved; innovation; novel; obesity in children; obesity prevention; programs; public health relevance; research facility; social; theories

DESCRIPTION (provided by applicant): We propose to establish a Center of Excellence on childhood obesity research and training, based on a transdisciplinary systems science framework and methodologies. We propose to use systems modeling approaches with integrated application of spatial analysis. Modeling will be guided by behavioral models and basic science regarding food intake and body weight regulation to study the complex determinants of childhood obesity and the impacts of environmental and policy interventions. We will undertake epidemiological research to study the cascading influences of macrosocial environmental factors on individual-level behaviors and biology using existing and new data from large cohorts of children and their families in the U.S. and in China. In proposed projects we synthesize epidemiological methods and designs with basic sciences to explore how social, environmental and individual factors relate synergistically to energy balance related behaviors to differential epigenetic programming. We will also evaluate a novel multilevel food access intervention that can become a model of effective and sustainable community-based interventions and policy changes, focusing on an urban low-income population at high risk of obesity. By combining features of previous effective intervention approaches, within a broader systems framework, we hope to make desirable, food choices more accessible, sustainable, and cost effective. In addition, we will encourage and support developmental research to develop and evaluate environmental and policy interventions in the proposed Pilot Study Core. We will establish a computational workshop for systems modeling and GIS-based investigation (Research Resource Core and Training Core) that will provide an infrastructure to advance the Center's training and research mission. We will train a new cohort of investigators at different career stages in emerging system-science theories and methods. Over 40 well established investigators from leading US and international institutions bring transdisciplinary expertise to bear in highly relevant areas. The Center will build upon a solid research and training base with ongoing NIH funded projects directly related to childhood obesity and systems analysis.

描述（由申请人提供）：我们建议基于跨学科系统科学框架和方法论建立儿童肥胖研究和培训卓越中心。我们建议将系统建模方法与空间分析的集成应用一起使用。建模将以行为模型和基础科学为指导，以研究食物摄入和体重调节，以研究儿童肥胖的复杂决定因素以及环境和政策干预的影响。我们将利用来自美国和中国大量儿童及其家人的现有和新数据来研究宏社会环境因素对个人水平行为和生物学的层叠影响对个人水平行为和生物学的层叠影响。在拟议的项目中，我们将流行病学方法和设计与基本科学合成，以探讨社会，环境和个人因素如何协同与能量平衡相关的行为与差异表观遗传学编程有关。我们还将评估一种新型的多层次食品访问干预措施，该干预措施可以成为有效且可持续的基于社区的干预措施和政策变化的模型，重点是肥胖风险高的城市低收入人群。通过在更广泛的系统框架内结合以前有效的干预方法的特征，我们希望使人们选择更容易获得，可持续和成本效益。此外，我们将鼓励和支持发展研究，以开发和评估拟议的试点研究核心中的环境和政策干预措施。我们将建立一个用于系统建模和基于GIS的调查（研究资源核心和培训核心）的计算研讨会，该研讨会将提供基础架构，以推动该中心的培训和研究任务。我们将在新兴的系统科学理论和方法中培训不同职业阶段的新研究人员。来自领先的美国和国际机构的40多名成熟良好的调查人员将跨学科的专业知识带入了高度相关的领域。该中心将以与儿童肥胖和系统分析直接相关的NIH资助项目进行稳固的研究和培训基础。