California Center of BD-STEPS - Finding Causes and Preventives of Birth Defects

加州 BD-STEPS 中心 - 寻找出生缺陷的原因和预防措施

• 批准号: 8911692
• 负责人: SUZAN L CARMICHAEL
• 金额: $ 80万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8911692
• 关键词: California; Center; BD; STEPS; Finding

DESCRIPTION (provided by applicant): Birth defects are the leading cause of infant mortality in the US. Birth defects also have enormous associated emotional and fiscal costs. The California Center's research efforts, both independently and in collaboration with other Centers for Birth Defects Research and Prevention (CBDRP) contributing to the National Birth Defects Prevention Study (NBDPS), have been at the forefront of public health birth defects research. With this new funding opportunity, our Center will further enhance scientific understanding of the potential causes of specific birth defects, which will undoubtedly have important implications for risk assessment and prevention of common, costly, and deadly malformations. In this application, we propose the following aims: Aim 1. Enhance the epidemiologic public health research capacity of the Centers for Birth Defects and Research and Prevention by actively participating in the Birth Defects Study to Evaluate Pregnancy Exposures (BD-STEPS) and Aim 2. Utilize data from BD-STEPS as well as NBDPS for collaborative and local studies that will identify potential modifiable risk factors for selected birth defects to reduce the public heath burden of birth defects in the US. The California Center is well-equipped to contribute to BD-STEPS - it is a world leader in birth defects epidemiology and highly experienced in the development, data collection, and dissemination of information from population-based studies of birth defects, exemplified by its performance within the CBDRP and its highly innovative research portfolio. Our Center has extensive experience conducting research related to the BD- STEPS areas of focus, which include maternal chronic medical conditions, diabetes, obesity, physical activity, infertility and medication use. We have proposed several analytic inquiries, complemented by the use of additional innovative datasets and analytic approaches, which will enable us to collaboratively continue elucidating the contribution of these and other modifiable risk factors to birth defects.

描述（由申请人提供）：先天缺陷是美国婴儿死亡率的主要原因。出生缺陷还具有巨大的相关情绪和财政成本。加利福尼亚中心的研究工作是独立和与其他出生缺陷研究与预防中心合作的研究（CBDRP），这是为国家出生缺陷预防研究（NBDPS）的贡献，一直处于公共卫生出生缺陷研究的最前沿。有了这个新的资金机会，我们的中心将进一步增强对特定先天缺陷的潜在原因的科学理解，这无疑将对风险评估和预防常见，昂贵和致命的畸形有重要影响。在本应用中，我们提出以下目的：目标1。通过主动参与出生缺陷研究，以评估妊娠暴露（BD阶段）（bd steps），增强中心的流行病学公共卫生研究能力，用于出生缺陷和研究和预防，并利用胎儿的数据限制，以识别NBD的影响，以识别NBD的影响，以确定妊娠的影响2。美国的出生缺陷负担。加利福尼亚中心有能力为BD步骤做出贡献 - 它是出生缺陷的世界领导者，是流行病学的世界领导者，并且在开发，数据收集以及从基于人群的先天缺陷研究中传播信息的经验丰富，这是其在CBDRP中的表现及其高度创新性的研究组合的表现。我们的中心拥有与BD-Steps重点领域有关的研究丰富的经验，包括孕产妇的慢性医疗状况，糖尿病，肥胖，体育锻炼，不育和药物使用。我们提出了一些分析询问，并通过使用其他创新数据集和分析方法来补充，这将使我们能够协作继续阐明这些和其他可修改的风险因素对源自缺陷的贡献。