Fetal Magnetocardiography Using Non-cryogenic Magnetic Field Sensors

使用非低温磁场传感器进行胎儿心磁图检查

• 批准号: 8589618
• 负责人: Vishal K Shah
• 金额: $ 57.54万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8589618
• 关键词: Adult; Appearance; Arrhythmia; Automobile Driving; Cardiac; Clinical; Clothing; Complex; Computer software; Coupled; Data; Devices; Diagnosis; Diagnostic; Electrocardiogram; Electronics; Electrophysiology (science); Environment; Evaluation; Evaluation Reports; Fetal Heart; Fetal Heart Rate; Fiber; Frequencies; Goals; Human; Investments; Lasers; Life; Light; Magnetism; Metals; Methods; Modification; Mothers; Mus; Operating System; Output; Patients; Peripheral; Persons; Phase; Pregnancy; Price; Research; Research Infrastructure; Shipping; Ships; Side; Signal Transduction; Slide; System; Technology; Temperature; Testing; Universities; Width; Wisconsin; analog; base; biomagnetism; commercialization; cost; cost effective; cryogenics; data acquisition; fetal; fetal diagnosis; heart rhythm; magnetic field; patient safety; prototype; public health relevance; sensor; superconducting quantum interference device

DESCRIPTION (provided by applicant): While the number of diagnostic technologies available for adult applications continues to grow, there remains a paucity of technologies suitable for fetal evaluation. In particular, noninvasive assessment of fetal cardiac electrophysiology has not been routinely possible despite many decades of fetal ECG research. Recently, a number of groups have demonstrated the efficacy of fetal magnetocardiography (fMCG), the magnetic analog of fetal ECG, as a new method of assessing fetal heart rate, rhythm, and conduction. The last few years have seen rapid progress in demonstrating the diagnostic efficacy of fMCG, as well as in magnetometer technology. The goal of this project is to reduce the price of a complete fetal MCG system from approximately $1M at present to below $100k. The system we propose to develop is based on new low-cost, room-temperature atomic magnetometers that are just as sensitive as existing superconducting magnetometers. During Phase I we established the feasibility of our approach through independent evaluation in a clinical environment. During Phase II we will develop a full-scale, turn-key system that is ready for commercialization.

描述（由申请人提供）：虽然可用于成人应用的诊断技术的数量持续增长，但适合胎儿评估的技术仍然很少。特别是，尽管胎儿心电图研究已有数十年，但对胎儿心脏电生理学的无创评估尚未成为可能。最近，许多研究小组已经证明了胎儿心磁图（fMCG）（胎儿心电图的磁模拟）作为评估胎儿心率、心律和传导的新方法的有效性。过去几年，fMCG 的诊断功效以及磁力计技术在展示方面取得了快速进展。该项目的目标是将完整胎儿 MCG 系统的价格从目前的约 100 万美元降至 10 万美元以下。我们建议开发的系统基于新型低成本、室温原子磁力计，其与现有超导磁力计一样灵敏。在第一阶段，我们通过临床环境中的独立评估确定了我们方法的可行性。在第二阶段，我们将开发一个全面的交钥匙系统，为商业化做好准备。