A Wearable Magnetocardiography Imaging System

可穿戴式心磁图成像系统

• 批准号: 10545643
• 负责人: Vishal K Shah
• 金额: $ 49.79万
• 依托单位: QUSPIN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10545643
• 关键词: 3-Dimensional; Ablation; Address; Affect; Algorithms; Alternative Therapies; Arrhythmia; Body Surface; Cardiac ablation; Catheters; Consumption; Data; Electric Conductivity; Electrocardiogram; Electrodes; Electroencephalography; Electrophysiology (science); Endocardium; Extravasation; Goals; Heterogeneity; Image; Imaging Techniques; Location; Magnetic Resonance Imaging; Magnetism; Magnetoencephalography; Maps; Measurement; Methods; Modality; Morbidity - disease rate; Optics; Patients; Penetration; Performance; Pharmaceutical Preparations; Phase; Pilot Projects; Positioning Attribute; Procedures; Property; Pump; Radiation therapy; Radiofrequency Interstitial Ablation; Records; Refractory; Research; Risk; Side; Signal Transduction; Study Subject; System; Techniques; Temperature; Testing; Time; Tissues; Ventricular Arrhythmia; Ventricular septum; X-Ray Computed Tomography; base; clinical investigation; cost effective; design; design and construction; heart imaging; imaging system; improved; magnetic field; millimeter; neuroimaging; patient population; programs; prototype; sensor; source localization; transmission process

PROJECT SUMMARY Recent studies have shown radiation therapy (RT) ablation to be a highly promising alternative therapy for patients with drug-refractory VT who are unable to undergo catheter-based ablation. Ideally, RT ablation is performed in conjunction with noninvasive electrophysiology (EP) imaging, such as ECG imaging (ECGI), so that the entire procedure is noninvasive; however, currently noninvasive EP imaging is much less accurate than RT and needs to be significantly improved to realize the full potential of RT ablation. In this project, we propose to utilize magnetocardiography (MCG) to develop an MCG imaging (MCGI) system. In comparison to ECG, MCG provides fundamental advantages for source localization and imaging due to the favorable transmission properties of magnetic signals. From a practical standpoint, MCG is more convenient because it is a contactless technique, whereas ECGI requires application of a large array of electrodes. The proposed system will be based on a revolutionary type of magnetic sensor, known as an optically-pumped magnetometer (OPM), which was first brought to market by our company. OPMs are far more practical than SQUID magnetometers because they are smaller, less expensive, and operate at room temperature. This will enable construction of an MCGI system with a conformal sensor array that covers the entire torso. The overall goal is to construct an MCGI system with improved accuracy and ease-of-use, compared to current ECGI/MCGI systems. The Phase I aims are to 1) determine an optimal sensor configuration for the MCGI system based on analysis of the spatial properties of the signal, 2) design a compact magnetic shield that is patient-friendly and minimizes the space requirements of the system, 3) devise a strategy for rapid, accurate digitization of the sensor locations, and 4) demonstrate the feasibility of key aspects of the proposed techniques in a small study of normal subjects.

项目概要 最近的研究表明放射治疗 (RT) 消融是一种非常有前途的替代方案 治疗无法接受导管消融的药物难治性 VT 患者。 理想情况下，RT 消融与无创电生理 (EP) 成像结合进行， 例如心电图成像（ECGI），使整个过程是无创的；然而，目前 无创 EP 成像的准确性远低于 RT，需要显着改进 充分发挥 RT 消融的潜力。 在这个项目中，我们建议利用心磁图 (MCG) 来开发 MCG 成像 （MCGI）系统。与 ECG 相比，MCG 为源提供了根本优势 由于磁信号良好的传输特性，定位和成像。来自一个 从实际角度来看，MCG 更方便，因为它是一种非接触式技术，而 ECGI 需要应用大量电极。拟议的系统将基于 革命性的磁传感器，称为光泵磁力计 (OPM)， 由我们公司首先推向市场。 OPM 比 SQUID 实用得多 磁力计，因为它们更小，更便宜，并且在室温下工作。这 将能够构建具有覆盖整个躯干的共形传感器阵列的 MCGI 系统。 总体目标是构建一个与现有技术相比具有更高准确性和易用性的 MCGI 系统 到当前的 ECGI/MCGI 系统。第一阶段的目标是 1) 确定最佳传感器 基于信号空间特性分析的 MCGI 系统配置，2) 设计 紧凑的磁屏蔽，对患者友好，并最大限度地减少了空间需求 系统，3) 设计一种快速、准确地数字化传感器位置的策略，以及 4) 在正常情况下的小型研究中证明所提出技术的关键方面的可行性 科目。