Intellectual and Developmental Disabilities Research Centers

智力和发育障碍研究中心

基本信息

批准号：
8708912
负责人：
SUSAN Y BOOKHEIMER
金额：
$ 126.57万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-08-01 至 2015-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8708912
关键词：
Animal Model Animals Anthropology Area Basic Science Bioinformatics California Cellular biology Childhood Childhood Brain Neoplasm Collaborations Communication D Cells Discipline Education Educational workshop Environment Epigenetic Process Epilepsy Faculty Fostering Fragile X Syndrome Goals Human Human Genetics Image Individual Institutes Interdisciplinary Study International Investigation Knowledge Mental Retardation and Developmental Disabilities Research Centers Mission Molecular Biology Nanotechnology Neurology Neurosciences Pathology Patients Phenotype Postdoctoral Fellow Psychiatry Psychology Quality of life Research Research Personnel Research Priority Resource Sharing Services Stem cells Technology Translational Research Translations Universities autism spectrum disorder base cellular imaging developmental disease developmentally disabled improved innovation intellectual and developmental disability investigator training neurosurgery pediatric pharmacology pre-doctoral prevent programs ranpirnase symposium

项目摘要

DESCRIPTION: Provided by Applicant: This application is for continued support of the administrative and research cores of the UCLA Intellectual and Developmental Disabilities Research Center (IDDRC). This IDDRC provides a comprehensive multidisciplinary research program in the field of intellectual and developmental disabilities. Importantly, the research investigations carried out by the Center Investigators encompass 23 of the 31 IDD research priorities listed in the current P30 RFA. This Center maintains and sharpens its focus on discovering ways to prevent and treat IDD, and to improve the quality of life for intellectual and developmentally disabled individuals, by fostering research innovation into the pathophysiological mechanisms of developmental disorders in animal models and also by patient-based research through interdisciplinary interactions among investigators. Newly emerging areas of excellence at the IDDRC, which extensively combine studies of human IDD and animal models, include studies of fragile X syndrome, autism spectrum disorders, pediatric brain tumors, and pediatric epilepsy. To serve these and other areas of excellence, the cores have been reorganized to provide much greater support for translational research while expanding cutting edge technology for the basic sciences. The eight cores are: (A) Administration and Communication, (B1) Neurogenomics and Bioinformatics and (B2) Epigenetics, (C) Stem Cells, (D) Cell Biology and Cellular Imaging, (E) Animal Models, (F) Electrophysiological Assessment, and (G) Translational Core for Human Phenotyping and Imaging. These cores are strengthened by the expertise of the increased number of IDDRC faculty involved with the cores, and the increased synergy among them. The mission of the Center is to provide an environment promoting the highest level of research in IDD by providing investigators open access to cutting edge and efficient core services in the IDDRC. The Center also organizes seminars, mini-symposia, an annual retreat, and core-based workshops to foster cohesive scientific discourse and collaboration. The Center assigns high priority to the support of talented young investigators and the training of pre- and postdoctoral fellows in a variety of disciplines related to its goals. The Center's mission is facilitated by strong ties with faculty in more than ten departments and institutes at UCLA excelling in neuroscience, genetics, human and animal imaging, nanotechnology, molecular biology, psychology, psychiatry, neurology, neurosurgery, pathology, pharmacology, pediatrics, education, and anthropology. The Center has recently begun interactions with a new IDD program at the University of Southern California, and it has increased interactions with national and international IDD researchers to share resources and knowledge to accelerate research breakthroughs and their translation.

描述：申请人提供：此申请是为了持续支持UCLA知识和发展障碍研究中心（IDDRC）的行政和研究核心。该IDDRC在智力和发展障碍领域提供了全面的多学科研究计划。重要的是，中心研究人员进行的研究调查包括当前P30 RFA中列出的31个IDD研究优先级中的23项。该中心通过将研究创新促进动物模型中发育障碍的病理生理机制，以及通过研究人员之间的跨学科研究来促进研究创新，以促进研究智力和发育残障人士的生活质量以及改善智力和发育残障人士的生活质量的关注和加强。 IDDRC的新兴领域广泛结合了人IDD和动物模型的研究，包括脆弱X综合征，自闭症谱系障碍，小儿脑肿瘤和小儿癫痫的研究。为了为这些卓越领域提供服务，对核心进行了重组，以为转化研究提供更大的支持，同时扩大基本科学的最前沿技术。八个核心是：（a）给药和交流，（b1）神经基因组学和生物信息学和（b2）表观遗传学，（c）干细胞，（d）细胞生物学和细胞成像，（e）动物模型，（f）电生理学评估，以及（g）人类现象型和成像的转换核心。这些核心通过与核心有关的IDDRC教师数量增加以及它们之间增加的协同作用的专业知识得到了加强。该中心的任务是通过为调查人员提供对IDDRC的最高优势和有效核心服务的开放访问，以提供一个促进IDD最高研究的环境。该中心还组织研讨会，迷你群岛，年度务虚会和基于核心的研讨会，以培养凝聚力的科学话语和协作。该中心将有才华的年轻调查员的支持以及在与目标相关的各种学科中的前和博士后研究员的培训方面具有很高的优先事项。 The Center's mission is facilitated by strong ties with faculty in more than ten departments and institutes at UCLA excelling in neuroscience, genetics, human and animal imaging, nanotechnology, molecular biology, psychology, psychiatry, neurology, neurosurgery, pathology, pharmacology, pediatrics, education, and anthropology. 该中心最近开始与南加州大学的新IDD计划进行互动，并增加了与国家和国际IDD研究人员的互动，以共享资源和知识，以加速研究突破及其翻译。

项目成果

期刊论文数量（461）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Corneal endothelial cell survival in organ cultures under acute oxidative stress: effect of VIP.

DOI：
发表时间：
2000-12
期刊：
Investigative ophthalmology & visual science
影响因子：
4.4
作者：
S. Koh;J. Waschek
通讯作者：
S. Koh;J. Waschek

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug.

DOI：
10.1016/j.celrep.2021.109957
发表时间：
2021-11-02
期刊：
Cell reports
影响因子：
8.8
作者：
Bi J;Khan A;Tang J;Armando AM;Wu S;Zhang W;Gimple RC;Reed A;Jing H;Koga T;Wong IT;Gu Y;Miki S;Yang H;Prager B;Curtis EJ;Wainwright DA;Furnari FB;Rich JN;Cloughesy TF;Kornblum HI;Quehenberger O;Rzhetsky A;Cravatt BF;Mischel PS
通讯作者：
Mischel PS

The relationship of congenital heart disease and respiratory infection mortality in patients with Down's syndrome.

唐氏综合症患者先天性心脏病与呼吸道感染死亡率的关系。