Utility of Effusion Cytology and Image Analysis in the Diagnosis of Mesothelioma

积液细胞学和图像分析在间皮瘤诊断中的应用

基本信息

批准号：
9369881
负责人：
Gustavo Kunde Rohde
金额：
$ 5.52万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9369881
关键词：
Utility Effusion Cytology Image Analysis

项目摘要

Mesothelioma is a rare though often fatal disease, often associated with exposure to asbestos. The differentiation of malignant mesothelioma from benign mesothelial proliferation is often achieved by assessing tissue invasiveness from histological examination of biopsy specimens. Pleural effusion (fluid between lung and the chest wall) cytology is often a less invasive procedure that can be made available in most hospitals. Diagnosis of this malignancy from cytology specimens is often not possible, given that tissue invasiveness cannot be assessed. Our proposal details a pilot project to be conducted in collaboration with the System Chair of Pathology and Laboratory Medicine of Western Pennsylvania Health System (Jan F. Silverman, M.D.), as well as the Anatomic Pathology Medical Director of the Cleveland Clinic (Tarik M. Elsheikh, M.D.) to test an image analysis approach most recently developed by Dr. Rohde's laboratory at Carnegie Mellon University (CMU) for cancer detection directly from pleural effusion cytology. Preliminary results resulting from the application of Dr. Rohde's methods to data provided by Dr. Silverman (detailed in the application) indicates the method can potentially be useful for diagnosis of malignant mesothelioma. The objective of the pilot study would be to test the accuracy of the method developed by Dr. Rohde's laboratory in differentiating malignant mesothelioma from benign mesothelial proliferation directly from effusion cytology with a larger cohort of patients from two institutions (WPAHS and CC). If successful, the completion of the project could have a significant impact in reducing overall costs and avoiding health risks associated with invasive procedures. The successful completion of this project could also pave the way for the application of similar techniques on several similar cytopathology diagnostic and prognostic challenges.

间皮瘤是一种罕见的，但通常是致命的疾病，通常与接触石棉有关。这恶性间皮瘤与良性间皮增殖的分化通常是通过通过组织学样本的组织学检查评估组织侵入性。胸腔积液（肺部和胸壁之间的流体）细胞学通常是一种侵入性的过程，可以做到这一点在大多数医院可用。从细胞学标本中诊断这种恶性肿瘤通常不是鉴于组织侵入性无法评估。我们的建议详细介绍了一个试点项目与西方病理学和实验室医学系统主席合作进行宾夕法尼亚州卫生系统（Jan F. Silverman，M.D。）以及解剖病理医学克利夫兰诊所（Tarik M. Elsheikh，M.D。）的主任测试图像分析方法大多数最近由卡内基·梅隆大学（CMU）的Rohde博士实验室开发直接从胸腔积液细胞学检测。适用的初步结果 Rohde博士对Silverman博士提供的数据的方法（申请中的详细信息）表明方法可能对诊断恶性间皮瘤有用。飞行员的目的研究是测试Rohde博士实验室开发的方法的准确性直接将恶性间皮瘤与良性间皮增殖与积液直接区分来自两个机构（WPAH和CC）的较大患者的细胞学学。如果成功，该项目的完成可能会对降低总体成本和避免健康产生重大影响与侵入性程序有关的风险。这个项目的成功完成也可以铺路在几种类似的细胞病理学诊断和预后挑战。