ADMINISTRATIVE CORE

行政核心

基本信息

批准号：
8677355
负责人：
Sanjay Asthana
金额：
$ 17.91万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8677355
关键词：
Achievement Address Administrator Advisory Committees Advocacy Aging Alzheimer&apos s Disease Animal Welfare Attention Autopsy Biological Markers Cells Collaborations Color Communication Communities Country Data Disease Education and Outreach Enrollment Ensure Ethics Exercise Extramural Activities Fostering Funding Future Genetic Goals Grant Grant Review Human Resources Institution Interdisciplinary Study Leadership Mission Monitor Participant Patient Care Performance Policies Productivity Regulation Research Research Infrastructure Research Personnel Research Project Grants Resources Review Committee Source Staging Universities Wisconsin aging brain brain tissue cooperative study healthy aging high standard human subject improved innovation meetings mild cognitive impairment neuroimaging normal aging novel pre-clinical programs repository socioeconomics success

项目摘要

ADMINISTRATIVE CORE (CORE A) - PROJECT SUMMARY The overall mission of the Wisconsin ADRC is to provide an infrastructure and resources conducive to conducting cutting-edge extramurally funded research in Alzheimer's disease (AD) and related disorders, with a special focus on the antecedent biomarkers of preclinical stages of the disease. The Administrative Core will set overall research directions and priorities, oversee all Core-related activities, ensure optimal utilization of the ADRC resources and serve as a resource to expand AD and aging research nationally and locally. Under the overall scientific and administrative leadership of Sanjay Asthana, MD, the Wisconsin ADRC Director, the Administrative Core will continue to exercise its leadership and accomplish its objectives through the activities of four major committees. The External Advisory Committee (EAC), comprised of distinguished leaders in AD research at institutions outside of Wisconsin and with expertise aligned with the scientific missions of the ADRC provides advice concerning the overall direction and performance of the Center. The Executive Committee, comprised of the ADRC Director, Associate Director, Administrator, Core-Leaders, Co- Core Leaders and Data Leader, meets monthly to discuss the overall function and scientific opportunities for the ADRC, review each Core's progress and resolve problems within or between Cores. The Resource Distribution Committee composed of the ADRC Director, Associate Director, Core Leaders, Administrator and ad hoc reviewers evaluates all requests for data, access to participants for enrollment in externally funded studies and ante-mortem biospecimens and postmortem brain tissue, and advises the Center Director and Executive Committee concerning resource utilization priorities. The Administrative Core places strong emphasis on wide utilization of the Wisconsin ADRC resources, but ensures distribution to support only high- quality research while avoiding competing uses for limited biospecimens. The Pilot Grant Review Committee performs competitive review of all the pilot grants submitted to the ADRC, prioritizing those from junior investigators with cutting-edge research and a strong likelihood of attracting external funding. Overall, the Administrative Core will continue to exercise scientific leadership and ensure ongoing success and excellence of the Wisconsin ADRC in the renewed cycle of funding.

行政核心（核心 A）- 项目摘要威斯康星州 ADRC 的总体使命是提供有利于开展有关阿尔茨海默病 (AD) 和相关疾病的尖端外部资助研究，特别关注疾病临床前阶段的先前生物标志物。行政核心将设定总体研究方向和优先事项，监督所有与核心相关的活动，确保最佳利用 ADRC 提供资源，并作为在全国和地方扩大 AD 和老龄化研究的资源。在 Sanjay Asthana 医学博士的全面科学和行政领导下，威斯康星州 ADRC 主任，行政核心将继续发挥领导作用，通过以下方式实现其目标：四个主要委员会的活动。外部咨询委员会 (EAC)，由杰出人士组成威斯康星州以外机构的 AD 研究领导者，具有与科学领域一致的专业知识 ADRC 的任务就该中心的总体方向和绩效提供建议。这执行委员会，由 ADRC 主任、副主任、行政人员、核心领导人、共同成员组成核心领导者和数据领导者每月举行一次会议，讨论总体功能和科学机会 ADRC，审查每个核心的进展并解决核心内部或之间的问题。资源分配委员会由 ADRC 主任、副主任、核心领导、管理员和特设审查员评估所有数据请求、访问参与者以注册外部资助的研究和死前生物样本和死后脑组织，并向中心主任和执行委员会关于资源利用优先事项。行政核心地位强大强调广泛利用威斯康星州 ADRC 资源，但确保分配仅支持高高质量的研究，同时避免有限生物样本的竞争使用。试点拨款审查委员会对提交给 ADRC 的所有试点拨款进行竞争性审查，优先考虑来自初级的拨款具有尖端研究并且很有可能吸引外部资金的研究人员。总体而言，行政核心将继续发挥科学领导作用，确保持续成功和卓越威斯康星州 ADRC 进入新的资助周期。